Senior Associate Scientist, Molecular Analytics BioEngineering

Bristol-Myers Squibb Company; Seattle (WA); Vor Ort; USD 103.000 - 124.000; Vollzeit

Benefits dieser Stelle

Flexible Time Off

11 paid holidays

Global Shutdown

Zusammenfassung

Bristol Myers Squibb in Seattle, WA seeks a Senior Associate Scientist to join the BioEngineering & Technology Innovation team in the Cell Therapy Research Thematic Research Center. You will develop and run engineered CAR T-cell assays, focusing on ddPCR/qPCR to assess gene editing in Cell Therapy products.

The role requires hands-on molecular biology work, nucleic acid extraction, data analysis, and collaboration with senior researchers to meet project goals in a fast-paced environment.

Qualifikationen

• Bachelor’s Degree or Master’s with appropriate bioscience experience.
• 4+ years of academic and/or industry experience (Bachelor’s track).
• 2+ years of academic and/or industry experience (Master’s track).
• Hands-on experience developing and running ddPCR assays, including primer/probe design and optimization, ideally for measuring gene-editing outcomes.
• Experience with nucleic acid extraction and characterization.
• Understanding of gene-editing technologies (CRISPR/Cas, base editing) and outcomes.

Aufgaben

• Develop, optimize, and run custom ddPCR assays to measure gene-editing outcomes in Cell Therapy products.
• Perform qPCR and ddPCR workflows on gene-edited samples and refine analytical approaches.
• Extract, clean up, and assess quality of nucleic acids from primary cells and cell lines.
• Optimize PCR parameters for targeted analyses.
• Design and execute experiments, analyze results, and communicate findings to inform decisions.
• Coordinate and collaborate with cross-functional teams to deliver molecular analytical methods for cell therapy.

Kenntnisse

ddPCR/qPCR hands-on

nucleic acid extraction

cell culture

data analysis in Excel

labs & documentation

collaboration

experimental design

Ausbildung

Bachelor’s degree

Master’s degree

Tools

ddPCR/qPCR platforms

QX200/QXOne/CFX Maestro

nucleic acid extraction kits

Leprechaun imaging platform

Jobbeschreibung

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

The Cell Therapy Thematic Research Center is one of BMS’s differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next‑generation, engineered cell‑based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes.

Position Summary

The Bioengineering and Technology Innovation team seeks a highly motivated, self‑driven Senior Associate Scientist dedicated to discovering and developing novel engineered CAR T‑cell therapies for cancer. The successful candidate will have hands‑on experience extracting and analyzing nucleic acids from primary cells and cell lines, with essential expertise in quantitative PCR (qPCR) and droplet digital PCR (ddPCR); cell culture experience is preferred. The primary focus is developing and running custom ddPCR assays to assess gene‑editing outcomes in Cell Therapy products and support preclinical CAR T asset development. Working with senior researchers in a fast‑paced, collaborative environment, the candidate will execute studies, analyze data, and communicate results.

Position Responsibilities

This is a hands‑on, laboratory‑based role within the Bioengineering & Technology Innovation team in the Cell Therapy Research Thematic Research Center. The ideal Senior Associate Scientist will:

• Develop, optimize, and run custom ddPCR assays—including primer and probe design—to measure gene‑editing outcomes in Cell Therapy products
• Perform qPCR and ddPCR workflows on gene‑edited samples and refine analytical approaches for lentiviral vector characterization
• Extract, clean up, and assess the quality of nucleic acids from primary cells and cell lines
• Optimize PCR parameters for targeted analyses
• Design and execute experiments, independently analyze and interpret results—including large, complex datasets—and communicate findings that inform team decisions
• Troubleshoot technical issues, select practical solutions, and contribute ideas for new methods and continuous improvement
• Maintain detailed, timely electronic laboratory notebook documentation and proactively update the team on progress
• Coordinate and collaborate with cross‑functional colleagues to deliver results and implement molecular analytical methods for cell therapy
• Represent the department or team on broader program or project teams as needed
• Work predominantly in the laboratory and on‑site full‑time, independently performing most day‑to‑day experimental work

The ideal candidate can independently design, execute, and troubleshoot experiments within established project goals, exercising sound scientific judgment while seeking guidance on complex or novel issues. They are expected to effectively manage their day‑to‑day work and priorities to meet deliverables.

Basic Qualifications

• Bachelor’s Degree
• 4+ years of academic and / or industry experience
• Or
• Master’s Degree
• 2+ years of academic and / or industry experience

Preferred Qualifications

• Bachelor’s degree in a scientific discipline with 4+ years of academic and/or industry experience, or a master’s degree with 2+ years of experience
• Hands‑on experience developing and running ddPCR assays, including primer/probe design and optimization, ideally for measuring gene‑editing outcomes is required
• Experience with nucleic acid extraction and characterization is required
• Understanding of gene‑editing technologies (e.g., CRISPR/Cas and base editing) and resulting genetic outcomes (e.g., indels and base conversions)
• Development experience of analytical assays to characterize lentiviral vectors, especially using the Leprechaun or other imaging‑based platforms is a strong plus
• Experience transducing cell lines or primary cells with lentiviral vectors
• Cell‑line and/or primary‑cell culture experience; cell sorting is a plus
• Experience running or optimizing immunofluorescence or fluorescence in situ hybridization assays is a strong plus
• Experience optimizing and/or running Western blots or automated Western blots (Wes, Jess)
• Experience with ddPCR/qPCR platforms and analysis software (e.g., QX200, QXOne, and CFX Maestro), RNA extraction, and RT‑qPCR
• Experience with column‑ and bead‑based nucleic acid extraction, liquid handlers, and quality‑control instruments (e.g., KingFisher Apex, Hamilton, Stunner, TapeStation, and Qubit)
• Ability to manage and interpret complex data from large sample sets, such as multiple 96‑ or 384‑well plates
• Familiarity with molecular biology and genetics, software such as SnapGene or Geneious, and electronic laboratory notebooks
• Strong organization, attention to detail, and documentation, with the ability to prioritize and meet commitments
• Excellent written and verbal communication and effective collaboration in large, cross‑functional teams
• Experience with data‑analysis tools such as JMP is a plus
• Experience performing data analysis in excel and using intermediate skills in Excel (lookup functions) is a plus
• Creative, flexible thinking and adaptability in a fast‑paced, changing environment

Compensation Overview

Seattle - WA: $102,570 - $124,290

The starting pay range(s) listed above is for full‑time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits

• Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).
• U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
• Non‑exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, employees may also have access to additional time‑off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.
• U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

• Where you work matters – because collaboration, innovation and patient impact happen in many settings.
• Our roles are structured across four work models: site‑essential, site‑by‑design, field‑based and remote‑by‑design. The model assigned to this role is based on its core responsibilities.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

For roles based in Washington State only: If you live in or expect to work from Washington State if hired for this position, please visit this page for important information about the Washington Fair Chance Act.

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at [e-mail] with the Job Title and Requisition number. Do not send application‑related inquiries to this email. To check your application status, please login to your Candidate Home Account.

R1607847 : Senior Associate Scientist, Molecular Analytics BioEngineering