Senior Associate Scientist, Immunology (in vivo/in vitro)

Seismic Therapeutic; Watertown (MA); On-site; USD 95,000 - 120,000; Full time

Job summary

SEISMIC THERAPEUTIC in Watertown, MA seeks a Senior Associate Scientist for In Vivo Pharmacology to support autoimmune disease programs. The role emphasizes hands-on in vivo/in vitro work, immune cell modulation, and pharmacodynamic assessment of novel therapeutics.

You will schedule and execute preclinical studies, coordinate logistics, and collaborate with project leads in a fast-paced, team-oriented environment. A strong background in biology and animal welfare is required.

Qualifications

• BS or MS with hands-on in vivo research experience and independent study execution.
• Proficiency with in vivo procedures including mouse handling and dosing.
• Experience with autoimmune or inflammatory disease models is a plus.
• Proficiency with GraphPad Prism and Excel for data analysis.
• Strong attention to detail and commitment to high-quality data and reproducibility.
• Commitment to IACUC and animal welfare policies.

Responsibilities

• Execute in vivo and in vitro studies supporting autoimmune disease programs and evaluate immune modulation and pharmacodynamics.
• Perform hands-on in vivo procedures including dosing (RO, IP, IV, SC), survival bleedings, tissue collection and necropsy.
• Collaborate with research leads on study design, endpoints, data interpretation and troubleshooting.
• Coordinate study logistics including dosing schedules, sample collection and reagent prep.
• Analyze, visualize and summarize study data; maintain records of data, samples and protocols.
• Ensure all work complies with IACUC-approved protocols and biosafety policies.

Skills

In vivo procedures

Mouse handling

Flow cytometry (preferred)

ELISA (preferred)

GraphPad Prism

Excel

Attention to detail

Animal welfare compliance

Education

BS or MS in Biology/Immunology/Pharmacology

Job description

If you are unable to complete this application due to a disability, contact this employer to ask for an accommodation or an alternative application process.

IMMUNOLOGY Full Time Employee Professional Watertown, MA, US

Salary Range: $95,000.00 To $120,000.00 Annually

SEISMIC THERAPEUTIC

About Seismic

Seismic Therapeutic TM is a clinical-stage biotechnology company making a major shift in how immunology therapies are discovered and developed. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life science investors and is located in the Boston area biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.

At our core, we are focused on phenomenal science, supportive culture, a superstar team, meritocracy, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality. Success will be the discovery and development of effective therapies for patients in need, and we invite you to become a part of that. This is a terrific opportunity for an experienced bioanalytical and biomarker operations professional to build the operational foundation for our assays and samples and join our small, dynamic and high-performing team.

Job Summary

Seismic is seeking a motivated Senior Associate Scientist to join our In Vivo Pharmacology team in support of autoimmune disease programs. This hands-on, in vivo/in vitro-based role centers on autoimmune and inflammatory models, including immune cell modulation and pharmacodynamic assessment of novel therapeutic candidates. The successful candidate will help schedule and execute preclinical in vivo, ex vivo and in vitro studies for research programs, performing procedures with a high degree of proficiency in a fast-paced, collaborative environment.

Key Responsibilities

• Execute in vivoand in vitro studies supporting autoimmune disease programs, evaluating immune cell modulation, inflammatory readouts, pharmacokinetics, pharmacodynamics and therapeutic efficacy
• Perform hands-on in vivo procedures, including compound administration (RO, IP, IV and SC), survival bleedings, blood and tissue collection, necropsy and clinical observations
• Partner with research leads on study design, endpoint selection, data interpretation and troubleshooting
• Coordinate study logistics, including dosing schedules, sample collection plans, reagent preparation and communication with research teams
• Analyze, visualize and summarize study data; maintain clear, timely records of data, sample inventories, protocols and study summaries
• Ensure all work complies with IACUC, animal welfare, biosafety and institutional policies

Required Qualifications

• BS or MS in Biology, Immunology, Pharmacology or a related field with 6+ (BS) / 3+ (MS) years of hands-on in vivo research experience and a demonstrated ability to execute studies with increasing independence
• Proficiency in common in vivo procedures, including mouse handling, dosing, blood collection, tissue harvest, necropsy and clinical monitoring, MSD/ELISA (preferred), flow cytometry (preferred).
• Experience with autoimmune or inflammatory disease models preferred
• Proficiency with GraphPad Prism and Excel preferred
• Strong attention to detail and commitment to high-quality data generation, documentation and reproducibility
• Commitment to animal welfare, ethical research practices and compliance with IACUC-approved protocols

Other

This role is based in Watertown, Massachusetts, with in-office expectations consistent with Seismic's company policies and business needs, including regular presence in our laboratory.

The annual base salary range for this position is $95,000.00 - $120,000.00. Salary is determined by several factors including, but not limited to, relevant experience, skills, qualifications, education and internal benchmarks.

Seismic Therapeutic is an equal opportunity employer. We welcome applicants of every background and make employment decisions without regard to race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran status, pregnancy, genetic information, or any other status protected by federal, state, or local law. If you need an accommodation during the application or interview process, please let us know.