Senior Analog/Mixed-Signal Hardware Engineer (Low-Noise PCB)

Pioneering Medicines; Cambridge (MA); On-site; USD 108,000 - 176,000; Full time

Job summary

Flagship Pioneering is seeking a Senior Electrical Engineer to own low-noise analog and mixed-signal PCB design for a next-generation biological sensing platform in Cambridge, MA. You will lead complex PCB development, drive HW/SW integration, and push for manufacturability from prototype to production.

You will collaborate with multidisciplinary teams, mentor junior engineers, and help shape the hardware strategy for high-performance, low-noise instruments across nano-scale measurements.

Qualifications

• B.S., M.S., or Ph.D. in Electrical Engineering or a related field.
• 5+ years of industry experience in PCB design and hardware development.
• Demonstrated expertise in multilayer PCB design for low-noise analog and mixed-signal systems.
• Deep understanding of signal integrity, power integrity, grounding strategies, and EMI/EMC mitigation.
• Hands-on experience with board bring-up, debugging, and lab instrumentation (oscilloscopes, logic analyzers, spectrum analyzers).
• Experience taking products from prototype through manufacturing.

Responsibilities

• Lead the design and development of complex, multilayer PCBs for advanced instrumentation systems, including low-noise, picoamp-level sensing electronics.
• Architect low-noise, mixed-signal circuit designs including analog front ends, power management, data acquisition, and embedded processing systems.
• Collaborate with SW and HW engineers as well as external vendors to ensure seamless hardware–software integration and instrument development.
• Develop and maintain comprehensive documentation including schematics, layout files, validation reports, and specifications.
• Drive design reviews, design for manufacturability (DFM), and design for testability (DFT) best practices.
• Contribute to intellectual property generation and technical strategy discussions.

Skills

Low-noise analog design

Mixed-signal PCB design

Signal integrity

Power integrity

EMI/EMC mitigation

Education

B.S. Electrical Engineering

M.S. Electrical Engineering

Ph.D. Electrical Engineering

Tools

Oscilloscopes

Logic analyzers

Spectrum analyzers

HDI design concepts

PCB bring-up

Job description

Flagship Pioneering is seeking a Senior Electrical Engineer to own low-noise analog and mixed-signal PCB design for a next-generation biological sensing platform in Cambridge, MA. You will lead complex PCB development, drive HW/SW integration, and push for manufacturability from prototype to production.

You will collaborate with multidisciplinary teams, mentor junior engineers, and help shape the hardware strategy for high-performance, low-noise instruments across nano-scale measurements.