Scientist - Translational Immunology

Slope; San Francisco (CA); On-site; USD 165,000 - 215,000; Full time

Job summary

Slope is seeking an Immunologist to design and validate biological strategies for establishing immune tolerance to novel proteins in brain-computer interfaces. Located in the San Francisco Bay Area, the successful candidate will work on characterizing immune responses and collaborate with interdisciplinary teams to enhance human compatibility. This role demands a PhD or equivalent experience and offers a compensation range of $165K - $215K, with full-time, on-site employment in the Bioengineering department.

Qualifications

• PhD in Immunology, Bioengineering, or a related field, or equivalent experience.
• Experience in designing and interpreting immune response experiments.
• Motivated understanding of mechanistic processes.

Responsibilities

• Characterize immunogenicity of engineered proteins.
• Scale high-throughput immune characterization assays.
• Collaborate with teams to enhance immunological tolerance.
• Drive projects from concept to execution with clear communication.

Skills

In vitro and in vivo experimental design

Quantitative reasoning

Cross-disciplinary collaboration

Education

PhD in Immunology, Bioengineering, or related field

Job description

Location

San Francisco Bay Area

Employment Type

Full time

Location Type

On‑site

Department

Bioengineering

Compensation

• $165K – $215K • Offers Equity

Merge Labs is a frontier research lab with the mission of bridging biological and artificial intelligence to maximize human ability, agency and experience. We’re pursuing this goal by developing fundamentally new approaches to brain‑computer interfaces that interact with the brain at high bandwidth, integrate with advanced AI, and are ultimately safe and accessible for anyone to use.

About the team:

Our Bio team designs, builds, and characterizes the biotechnologies that form the foundation of next‑generation brain‑computer interfaces. We combine molecular engineering, synthetic biology, neuroscience and advanced physical methods such as ultrasound to establish less invasive, high‑bandwidth connections with neurons. The Bio team develops our core molecular technologies, validates their performance in vitro and in vivo, and demonstrates their advanced capabilities in animal models. We build custom experimental setups and pipelines and collaborate closely with engineers and data scientists. We work across disciplines to come up with creative ideas and solve some of the most challenging problems in biotechnology.

About the role:

As an Immunologist, you will design, build, and validate biological strategies to establish durable immune tolerance to novel proteins involved in developing less invasive brain‑computer interfaces. You will apply your expertise to characterize immune responses and develop strategies that promote immunological tolerance. Your work will establish the immunological foundation for next‑generation molecular brain‑computer interfaces.

In this role, you will:

• Characterize the immunogenicity of engineered proteins, establishing quantitative readouts and benchmarks for immune compatibility in relevant in vitro and in vivo experimental models.
• Scale high‑throughput immune characterization assays and workflows to enable rapid hypothesis testing and iteration.
• Collaborate with our computational and protein engineering teams to design and execute strategies to enhance immunological tolerance to molecular components of next‑generation brain‑computer interfaces to improve human compatibility.
• Drive technical ownership of projects from concept to execution, including experimental planning, prioritization, documentation, and clear communication of results.

You might thrive in this role if you have:

• Have a PhD in Immunology, Bioengineering, or a related field, or have equivalent experience leading research projects end‑to‑end.
• Are proficient in designing, executing, and interpreting in vitro and in vivo experiments that interrogate immune responses, with strong experimental rigor and quantitative reasoning.
• Are comfortable contributing to the design and evaluation of innovative solutions aimed at promoting immune tolerance.
• Think mechanistically: you are motivated by understanding how things work, not just that they work.
• Feel joy in collaboration and communicate naturally with experts across disciplines.
• Are energized by 0->1 innovations and always on the lookout for creative ways to do better.
• Want to be part of a fast‑paced team working on frontier scientific and technical problems.

If you're excited about this role but don't meet every qualification, please apply. As we build, we're hiring for complementary strengths to form a high‑impact team.

Merge Labs does not discriminate on the basis of race, color, religion, national origin, age, sex, sexual orientation, gender, gender identity, gender expression, marital status, physical or mental disability, medical condition, genetic information, family status, ancestry, citizenship, U.S. military (state and federal) and veteran status, or any other legally protected status. It is our intention that all applicants be given equal opportunity and that selection decisions are based on job related factors. We are an equal opportunity employer.

Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.

We are committed to providing reasonable accommodations to applicants with disabilities, and requests can be made by emailing [e-mail].

Compensation Range: $165K - $215K