Scientist / Sr. Scientist In Vivo Translational Sciences

altoslabs; San Francisco (CA); On-site; USD 148,000 - 220,000; Full time

Job summary

Altos Labs seeks a Scientist to join the In Vivo Translational Sciences team within Drug Discovery and Development Sciences (3DS). You will own the full lifecycle of in vivo pharmacology studies, from design and protocol development to execution, analysis, and reporting to program teams.

The role requires deep experience in in vivo rodent research in mice and rats, a strong focus on animal welfare, and collaboration with cross-functional partners to advance therapeutic programs while upholding

Qualifications

• Ph.D. in biological sciences with 3–5 years (Scientist) or 6+ years (Sr. Scientist) in drug discovery.
• Extensive in vivo rodent research experience in mice and rats.
• Strong communication and organizational skills; independent and collaborative.

Responsibilities

• Lead the full lifecycle of in vivo pharmacology studies across multiple projects, providing in vivo pharmacology and physiology expertise from study design through data reporting.
• Contribute to the selection of pharmacodynamic and target-engagement readouts.
• Contribute to building translational strategy by leveraging in vivo research for target validation and candidate progression.
• Develop, characterize, and implement new animal models including models of fibrosis and age-related pathologies.
• Evaluate and implement new technologies and best practices for in vivo research to enhance study efficiency and quality.
• Execute studies in mice and rats, including survival surgeries using aseptic technique.
• Occasionally perform downstream ex vivo analyses.
• Maintain detailed documentation in the electronic lab notebook for data integrity.
• Collaborate with cross-functional partners across discovery biology, pharmacology, DMPK, and technology development to advance programs.
• Ensure all in vivo work meets IACUC-approved protocols and uphold high ethical standards.

Skills

In vivo pharmacology

Animal welfare

Communication

Project management

Molecular biology

Data analysis

Education

Ph.D. in biological sciences

Tools

PCR

Western blot

ELISA

In vivo models

Job description

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

For more information, see our website at altoslabs.com.

Our Value

Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission .

Diversity at Altos

Altos Labs has been named one of the Top 3 Biotech Companies and ranked for the second year on the Forbes 2026 Best Startups in America list. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

An exciting opportunity is available for a Scientist to join the In Vivo Translational Sciences team within Drug Discovery and Development Sciences (3DS) at Altos Labs.

We are seeking a dedicated and highly skilled Scientist for our In Vivo Pharmacology Operations. In this role you will be responsible for the full lifecycle of in vivo pharmacology studies - from design and protocol development through execution, analysis, and interpretation - to support the progression of our therapeutic programs. This role demands a solid understanding of in vivo research methodologies and the ability to operate in a complex, fast-moving research environment.

Responsibilities

• Lead the full lifecycle of in vivo pharmacology studies across multiple projects - providing in vivo pharmacology and physiology expertise from study design and model selection through dosing and in-life monitoring, tissue collection and processing, data analysis, interpretation, and reporting of results to program teams
• Contribute to selection of pharmacodynamic and target-engagement readouts
• Contribute to building translational strategy by leveraging in vivo research for target validation and candidate progression
• Develop, characterize, and implement new animal models; including models of fibrosis and other age-related pathologies
• Evaluate and implement new technologies, platforms, and best practices for in vivo research to enhance study efficiency and quality
• Execute studies in both mice and rats, including conducting survival surgeries to establish rodent models using aseptic technique
• Occasionally execute downstream ex vivo analyses
• Maintain detailed documentation of all studies in the electronic lab notebook to ensure data integrity and traceability
• Collaborate with cross-functional partners across discovery biology, pharmacology and assay sciences, DMPK, and technology development to advance therapeutic programs
• Ensure all in vivo work meets IACUC-approved protocols and uphold the highest ethical standards in study conduct
• Contribute to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion

Who You Are

• Ph.D. in biological sciences with a minimum of 3-5 years (Scientist) and 6+ years (Sr. Scientist) of industry experience in a drug discovery and development setting
• Extensive expertise with all aspects of in vivo rodent research (various dosing routes, anesthesia, surgical procedures, necropsy, tissue processing, etc.) in both mice and rats
• Strong commitment to animal welfare and a 3Rs-centered approach to experimental design
• Excellent communication skills for effective collaboration with internal teams and external CRO partners
• Exceptional organizational skills, strong attention to detail, and the ability to work independently and collaboratively in a dynamic environment
• Demonstrate creative thinking and a proactive, solution-oriented mindset; able to design, troubleshoot, and refine complex in vivo studies with resourcefulness and innovation
• High-level problem-solving ability with strong analytical thinking and the capacity to make practical, data-driven decisions
• Hands-on experience with molecular and cell biology techniques (RNA/DNA extraction, PCR, Western blot, ELISA, and small molecule/biologic assays)
• Willingness and ability to work in a lab/vivarium environment for the majority of working hours, including supporting weekend study needs

Preferred Qualifications

• Experience working across diverse therapeutic modalities, including small molecules, biotherapeutics, nucleic acid therapeutics, and gene therapy is highly desirable
• Experience analyzing age-related diseases/deficits in animal models, including fibrosis, inflammation, metabolic disorders or neurodegeneration

Salary

The salary range for Redwood City, CA

• Scientist II, In Vivo Pharmacology : $148,400 - $190,300
• Senior Scientist I, In Vivo Pharmacology $171,400 - $219,700
• Exact compensation may vary based on skills, experience, and location.

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