Scientist / Sr. Scientist In Vivo Translational Sciences

CHEManager International; San Francisco (CA); On-site; USD 148,000 - 220,000; Full time

Job summary

Altos Labs, based in Redwood City, CA, seeks a Scientist to join the In Vivo Pharmacology Operations within 3DS. You will manage full lifecycle in vivo studies, from design and protocol development to execution and data interpretation, supporting therapeutic program progression.

The role requires extensive in vivo rodent experience, strong data analysis, and collaboration across discovery biology, pharmacology, DMPK, and tech development. Ethical conduct and 3Rs-focused design are essential.

Qualifications

• Ph.D. in biological sciences with industry experience in drug discovery and development (3–5 years for Scientist, 6+ for Sr. Scientist).
• In vivo rodent research experience in mice and rats, including dosing, anesthesia, and necropsy.
• Strong emphasis on animal welfare and 3Rs-centered design.

Responsibilities

• Lead full lifecycle of in vivo pharmacology studies across projects, including design, dosing, data analysis and reporting.
• Contribute to pharmacodynamic readouts and translational strategy for candidate progression.
• Develop animal models (fibrosis and age-related pathologies) and implement new technologies.
• Collaborate with cross-functional teams to advance therapeutic programs and ensure IACUC compliance.

Skills

In vivo pharmacology

Rodent surgery

Data analysis

Molecular biology

Communication

Team collaboration

Documentation

Experimental design

Education

Ph.D. in biological sciences

Tools

RNA/DNA extraction

PCR

Western blot

ELISA

Job description

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

For more information, see our website at altoslabs.com.

Our Value

Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission.

Diversity at Altos

Altos Labs has been named one of the Top 3 Biotech Companies and ranked for the second year on the Forbes 2026 Best Startups in America list. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

An exciting opportunity is available for a Scientist to join the In Vivo Translational Sciences team within Drug Discovery and Development Sciences (3DS) at Altos Labs.

We are seeking a dedicated and highly skilled Scientist for our In Vivo Pharmacology Operations. In this role you will be responsible for the full lifecycle of in vivo pharmacology studies - from design and protocol development through execution, analysis, and interpretation - to support the progression of our therapeutic programs. This role demands a solid understanding of in vivo research methodologies and the ability to operate in a complex, fast-moving research environment.

Responsibilities

• Lead the full lifecycle of in vivo pharmacology studies across multiple projects - providing in vivo pharmacology and physiology expertise from study design and model selection through dosing and in-life monitoring, tissue collection and processing, data analysis, interpretation, and reporting of results to program teams
• Contribute to selection of pharmacodynamic and target-engagement readouts
• Contribute to building translational strategy by leveraging in vivo research for target validation and candidate progression
• Develop, characterize, and implement new animal models; including models of fibrosis and other age-related pathologies
• Evaluate and implement new technologies, platforms, and best practices for in vivo research to enhance study efficiency and quality
• Execute studies in both mice and rats, including conducting survival surgeries to establish rodent models using aseptic technique
• Occasionally execute downstream ex vivo analyses
• Maintain detailed documentation of all studies in the electronic lab notebook to ensure data integrity and traceability
• Collaborate with cross-functional partners across discovery biology, pharmacology and assay sciences, DMPK, and technology development to advance therapeutic programs
• Ensure all in vivo work meets IACUC-approved protocols and uphold the highest ethical standards in study conduct
• Contribute to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion

Who You Are

• Ph.D. in biological sciences with a minimum of 3-5 years (Scientist) and 6+ years (Sr. Scientist) of industry experience in a drug discovery and development setting
• Extensive expertise with all aspects of in vivo rodent research (various dosing routes, anesthesia, surgical procedures, necropsy, tissue processing, etc.) in both mice and rats
• Strong commitment to animal welfare and a 3Rs-centered approach to experimental design
• Excellent communication skills for effective collaboration with internal teams and external CRO partners
• Exceptional organizational skills, strong attention to detail, and the ability to work independently and collaboratively in a dynamic environment
• Demonstrate creative thinking and a proactive, solution-oriented mindset; able to design, troubleshoot, and refine complex in vivo studies with resourcefulness and innovation
• High-level problem-solving ability with strong analytical thinking and the capacity to make practical, data-driven decisions
• Hands-on experience with molecular and cell biology techniques (RNA/DNA extraction, PCR, Western blot, ELISA, and small molecule/biologic assays)
• Willingness and ability to work in a lab/vivarium environment for the majority of working hours, including supporting weekend study needs

Preferred Qualifications

• Experience working across diverse therapeutic modalities, including small molecules, biotherapeutics, nucleic acid therapeutics, and gene therapy is highly desirable
• Experience analyzing age-related diseases/deficits in animal models, including fibrosis, inflammation, metabolic disorders or neurodegeneration

The salary range for Redwood City, CA

• Scientist II, In Vivo Pharmacology: $148,400 - $190,300
• Senior Scientist I, In Vivo Pharmacology $171,400 - $219,700

Exact compensation may vary based on skills, experience, and location.

For UK Applicants, Before Submitting Your Application

• Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice)
• This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment.

Equal Opportunity Employment

We value collaboration and scientific excellence.

We believe that a culture of belonging are foundational to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining an inclusive environment.

Altos Labs provides equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Altos prohibits unlawful discrimination and harassment. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging.

Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at https://www.linkedin.com/pulse/how-spot-avoid-online-job-scams-biron-clark/