Scientist/Senior Scientist, High-Throughput Screening Bay Area - - On-site

Until Labs; San Francisco (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

401(k) retirement plan

Commuter benefits

Lunch and dinners

Job summary

Until Labs in San Francisco is assembling an interdisciplinary team to advance high-throughput screening for cryoprotectants and related formulations. The Scientist/Senior Scientist will lead day-to-day screening efforts, optimize workflows, and develop mechanistic assays to understand cellular toxicity and viability.

Qualifications

• PhD or equivalent experience in toxicology, pharmacology, cell biology, physiology, bioengineering, chemical engineering, or related field.
• Independent design and execution of cell-based HTS workflows.
• Experience with primary cells or iPSC-derived models.
• Mechanistic assays to identify drivers of toxicity.

Responsibilities

• Coordinate day-to-day screening team activities and plan experiments.
• Improve screening workflow from cell culture readiness to data analysis and QA.
• Increase throughput while preserving biological relevance and data quality.
• Design and execute functional assays post-cryoprotectant exposure.
• Develop mechanism-of-action assays to guide formulation design.
• Integrate renal, cardiac, and hepatic models into screening pipelines.
• Analyze multiparametric datasets and communicate actionable recommendations.

Skills

HTS workflow design

Cell biology

Assay development

Data analysis

Toxicology knowledge

Team leadership

Education

PhD in Toxicology or related field

Tools

Plate readers

Flow cytometry

LC-MS

HPLC

Job description

Scientist/Senior Scientist, High-Throughput Screening

Until is a moonshot company building a “pause button” for biology. Our near-term focus is organ-scale reversible cryopreservation: preserving donated organs at subzero temperatures without ice formation, then rewarming them uniformly for transplant. By solving this grand challenge, we’re laying the foundation for whole-body reversible cryopreservation, giving patients a bridge to future cures.

To achieve our goal, we are assembling an interdisciplinary team to develop perfusion systems, cryoprotectant formulations, and vitrification and rewarming hardware.

We envision a future where no transplantable organ is lost to logistics, and no terminal diagnosis is final because patients can safely wait for future medicine to arrive.

About the Role

We are seeking a Scientist/Senior Scientist, High-Throughput Screening to manage the day-to-day execution of our cryoprotectant screening program. You will be responsible for improving an established screening workflow, increasing throughput, identifying less-toxic formulations, and advancing our understanding of how cryoprotectants affect cell viability and function.

Working closely with assay scientists, biologists, and automation engineers, you will integrate primary cells and iPSC-derived models into scalable screening workflows. You will develop mechanism-of-action assays, investigate cellular mechanisms of toxicity. This role combines hands-on experimental work, team coordination, and responsibility for delivering screening milestones that support organ-scale reversible cryopreservation.

You Will

Coordinate the screening team’s day-to-day work, plan experiments, mentor team members, and ensure timely delivery of screening milestones.

Manage and improve the screening workflow from cell-culture readiness and HTS assay execution through data analysis, quality control, and interpretation.

Increase screening throughput and reproducibility in partnership with automation engineers while maintaining biological relevance and data quality.

Design and execute functional assays to characterize cellular responses following cryoprotectant exposure.

Develop and validate mechanism-of-action assays to identify drivers of toxicity and guide the design of less-toxic formulations.

Improve the integration of renal, cardiac, and hepatic cell models using primary cells or iPSC-derived cells into the screening pipeline.

Use chromatography and mass spectrometry to assess the purity of compounds used in cryoprotectant screening.

Analyze multiparametric datasets, prioritize findings for follow-up, and communicate actionable recommendations to colleagues developing cryoprotectant formulations.

You Are

Trained at the PhD level in Toxicology, Pharmacology, Cell Biology, Physiology, Bioengineering, Chemical Engineering, Tissue Engineering, or a related field, or bring equivalent expertise through at least four years of relevant experience managing research projects end to end.

Experienced in independently designing, executing, and improving cell-based high-throughput screening workflows.

Skilled in assay development using primary cells or iPSC-derived cells, with experience in at least one renal, cardiac, or hepatic model.

Experienced in developing mechanistic assays and translating screening results into testable hypotheses about cellular toxicity.

Comfortable working hands-on with plate-based assays, imaging, flow cytometry, and analytical chemistry methods such as HPLC, LC-MS, or GC-MS for compound purity assessment.

Experienced in quantitative analysis of screening data, including quality control, statistical interpretation, and analysis of multiple experimental readouts.

Able to coordinate and mentor a scientific team, manage interdependent workflows, and take responsibility for experimental execution and outcomes.

Collaborative, receptive to diverse perspectives, and comfortable adapting priorities in a fast-paced, mission-driven research environment.

Preferred Qualifications

Experience scaling automated screening workflows in close partnership with lab automation engineers.

Experience integrating iPSC-derived cells or advanced 3D models into high-throughput screening pipelines.

Experience with high-content imaging, transcriptomics, or other approaches that connect cellular phenotypes to mechanisms of toxicity.

Proficiency in Python or R for analysis, visualization, and interpretation of complex screening datasets.

Experience relating compound purity measurements to biological assay results.

Generous medical, dental and vision insurance coverage

Flexible time off and paid holidays

Competitive compensation package, including salary and equity

Access to a 401(k) retirement savings plan

FSA and commuter benefits

Daily lunch and dinners, plus a variety of snacks

Monthly learning stipend

On-site fitness center

Quarterly team social budget

Ready to Apply?

Join our team and be part of the future of medicine and technology.