Scientist, Pharmacokinetics (Onsite)

Merck; West Point (PA); On-site; USD 87,000 - 137,000; Full time

Benefits offered by this job

Medical

Dental

Vision health care

Other insurance benefits

Retirement benefits (401(k))

Paid holidays

Vacation

Sick days

Job summary

Merck in West Point, Pennsylvania is seeking a bioanalytical scientist to execute quantitative LC-MS and LBA methods for small and large molecules. You will generate PK/PD data, validate workflows, and contribute to early development programs in a multidisciplinary team.

The role requires a Bachelor’s degree with relevant lab experience or an MS, plus experience with LC-MS/MS, LBA, and automated sample prep. Emphasis on compliance, safety, and quality data.

Qualifications

• Bachelor’s degree with 3+ years in analytical chemistry or related field, or MS with 1–2 years experience.
• Experience quantifying bioanalytical data for PK/PD programs is required.
• Experience with LC-MS/MS and LBA approaches is preferred.

Responsibilities

• Method Execution & Troubleshooting: Develop, validate, and execute quantitative bioanalytical methods using LC-MS/MS, LBA, and/or hybrid LC-MS/LBA workflows to support discovery and early development programs.
• Data Delivery: Generate, analyze, and deliver high-quality bioanalytical data for PK, PD, and in vitro studies of both small and large molecule therapeutics within established timelines.
• Sample Preparation: Perform manual and automated sample preparation (e.g., protein precipitation, solid-phase extraction, immunocapture/affinity purification for biological matrices).
• Lab Operations & Compliance: Maintain laboratory equipment and ensure all operations strictly adhere to safety, internal SOPs, and regulatory guidelines.
• Automation Integration: Support high-throughput workflows by operating and troubleshooting robotics and automated systems.

Skills

Bioanalysis

Biochemistry

Biotherapeutics

Cell Culture Techniques

Ethical Compliance

GMP Documentation

GLPs

Immunoassays

LC-MS

Laboratory Instrumentation

Pharmacokinetics

Pharmacology

Small Molecules

Education

Bachelor’s degree with 3+ years relevant lab experience or MS degree (1-2 years relevant experience)

Tools

LC-MS platforms

Ligand Binding Assays (LBA)

Job description

Job Description

The department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) is seeking a highly motivated bioanalytical scientist to contribute to our drug discovery and early pre-clinical development efforts.

The Scientist will be responsible for execution and troubleshooting of quantitative bioanalytical methods of small molecules, peptides, and large molecules (biologics), utilizing both LC-MS and Ligand Binding Assay (LBA) platforms to deliver high-quality data that drives our pipeline forward.

Key Responsibilities

• Method Execution & Troubleshooting: Develop, validate, and execute robust quantitative bioanalytical methods using LC-MS/MS, Ligand Binding Assays (LBA), and/or hybrid LC-MS/LBA workflows to support discovery and early development programs.
• Data Delivery: Generate, analyze, and deliver high-quality bioanalytical data for PK, PD, and in vitro studies of both small and large molecule therapeutics within established timelines.
• Sample Preparation: Perform manual and automated sample preparation (e.g., protein precipitation, solid-phase extraction, immunocapture/affinity purification for biological matrices).
• Lab Operations & Compliance: Maintain laboratory equipment and ensure all operations strictly adhere to safety, internal SOPs, and regulatory guidelines.
• Automation Integration: Support high-throughput workflows by operating and troubleshooting robotics and automated systems.

Education Minimum Requirement

• Bachelor’s degree with 3+ years relevant laboratory experience or MS degree (1-2 years relevant experience) in analytical chemistry, pharmaceutical sciences, pharmacology, biomedical, chemical engineering or related field.

Required Experience & Skills

• Large Molecule & LBA Experience: Experience with Ligand Binding Assays (LBA) quantitation of large molecules/biologics.
• Teamwork & Interpersonal Skills: Demonstrated ability to collaborate effectively within high-performing, multidisciplinary scientific teams.
• Communication: Excellent written and verbal communication skills, with the ability to present scientific data clearly.
• Technical Proficiency: Proficient in Microsoft Office Suite (Excel, Word, PowerPoint) and standard laboratory software.

Preferred Skills:

• Data Analysis: A basic understanding of statistical analysis and pharmacokinetic principles.
• Small Molecule & Peptide Analysis: Experience with liquid chromatography (LC) and mass spectrometry (MS) for the quantitative analysis of small molecules and/or peptides in biological matrices.

Required Skills:

• Bioanalysis
• Biochemistry
• Biotherapeutics
• Cell Culture Techniques
• Ethical Compliance
• GMP Documentation
• Good Laboratory Practices (GLPs)
• Immunoassays
• Laboratory Instrumentation
• Laboratory Management
• Laboratory Safety
• Liquid Chromatography-Mass Spectrometry (LC-MS)
• Pharmaceutical Sciences
• Pharmacodynamics
• Pharmacokinetics
• Pharmacology
• Small Molecules

US And Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.

As An Equal Employment Opportunity Employer, We Provide Equal Opportunities To All Employees And Applicants For Employment And Prohibit Discrimination On The Basis Of Race, Color, Age, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Protected Veteran Status, Disability Status, Or Other Applicable Legally Protected Characteristics.

As a Federal Contractor, We Comply With All affirmative action requirements For Protected Veterans And Individuals With Disabilities.

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts.

EEOC Know Your Rights

EEOC GINA Supplement

The primary location for this posting is:

USA - Pennsylvania - West Point

Where required by law, the compensation range for this role is provided below.

The salary range for the primary location of this role is:

$87,300.00 - $137,400.00

This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

• medical
• dental
• vision healthcare
• other insurance benefits (for employee and family)
• retirement benefits, including 401(k)
• paid holidays
• vacation
• compassionate and sick days

Additional location(s):

Please note the salary range above applies to the Primary Location of the position. Where a role has other listed locations, different compensation guidelines may apply. You may find the salary ranges for additional locations below. If the salary range is not listed for the location you are applying to, our Talent Acquisition team will provide further information to you relevant to your location.

Additional location(s) Compensation Information:

San Francisco Residents Only:

We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:

We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

Biological matrices

Job Posting End Date:

11/2/2026

Requisition ID:

R423274