Scientist, Pharmacokinetics (Onsite)

Merck; West Point (PA); On-site; USD 87,000 - 137,000; Full time

Job summary

Merck in West Point, PA seeks a bioanalytical scientist to execute quantitative methods using LC-MS/MS and LBA for small to large molecules. You will handle sample prep, data analysis, and ensure compliance with SOPs, while contributing to high-throughput, automated workflows.

The role emphasizes collaboration within multidisciplinary teams and strong communication of complex data to drive early development programs.

Qualifications

• Bachelors with 3+ years lab experience or MS with 1-2 years experience.
• Experience with LBA quantitation of large molecules/biologics.
• Excellent written and verbal communication skills.
• Ability to collaborate in multidisciplinary teams.

Responsibilities

• Develop, validate and execute quantitative bioanalytical methods using LC-MS/MS and/or LBA.
• Generate and deliver bioanalytical data for PK/PD and in vitro studies.
• Perform manual and automated sample preparation (e.g., SPE, protein precipitation).
• Maintain lab operations in compliance with SOPs and safety guidelines.
• Support high-throughput workflows by operating robotics and automated systems.

Skills

Bioanalysis

LC-MS/MS

Teamwork

Communication

SOP Compliance

Data analysis

Microsoft Office

Laboratory Safety

Robotics

Education

Bachelor’s degree with 3+ years relevant laboratory experience or MS degree (1-2 years relevant experience)

Tools

LC-MS/MS

LBA platforms

Automation systems

Job description

Job Description

The department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) is seeking a highly motivated bioanalytical scientist to contribute to our drug discovery and early pre-clinical development efforts.

The Scientist will be responsible for execution and troubleshooting of quantitative bioanalytical methods of small molecules, peptides, and large molecules (biologics), utilizing both LC-MS and Ligand Binding Assay (LBA) platforms to deliver high-quality data that drives our pipeline forward.

Key Responsibilities

• Method Execution & Troubleshooting: Develop, validate, and execute robust quantitative bioanalytical methods using LC-MS/MS, Ligand Binding Assays (LBA), and/or hybrid LC-MS/LBA workflows to support discovery and early development programs.
• Data Delivery: Generate, analyze, and deliver high-quality bioanalytical data for PK, PD, and in vitro studies of both small and large molecule therapeutics within established timelines.
• Sample Preparation: Perform manual and automated sample preparation (e.g., protein precipitation, solid-phase extraction, immunocapture/affinity purification for biological matrices).
• Lab Operations & Compliance: Maintain laboratory equipment and ensure all operations strictly adhere to safety, internal SOPs, and regulatory guidelines.
• Automation Integration: Support high-throughput workflows by operating and troubleshooting robotics and automated systems.

Education Minimum Requirement

• Bachelor’s degree with 3+ years relevant laboratory experience or MS degree (1-2 years relevant experience) in analytical chemistry, pharmaceutical sciences, pharmacology, biomedical, chemical engineering or related field.

Required Experience & Skills

• Large Molecule & LBA Experience: Experience with Ligand Binding Assays (LBA) quantitation of large molecules/biologics.
• Teamwork & Interpersonal Skills: Demonstrated ability to collaborate effectively within high-performing, multidisciplinary scientific teams.
• Communication: Excellent written and verbal communication skills, with the ability to present scientific data clearly.
• Technical Proficiency: Proficient in Microsoft Office Suite (Excel, Word, PowerPoint) and standard laboratory software.

Preferred Skills

• Data Analysis: A basic understanding of statistical analysis and pharmacokinetic principles.
• Small Molecule & Peptide Analysis: Experience with liquid chromatography (LC) and mass spectrometry (MS) for the quantitative analysis of small molecules and/or peptides in biological matrices.

Required Skills

• Bioanalysis
• Biochemistry
• Biotherapeutics
• Cell Culture Techniques
• Ethical Compliance
• GMP Documentation
• Good Laboratory Practices (GLPs)
• Immunoassays
• Laboratory Instrumentation
• Laboratory Management
• Laboratory Safety
• Liquid Chromatography-Mass Spectrometry (LC-MS)
• Pharmaceutical Sciences
• Pharmacodynamics
• Pharmacokinetics
• Pharmacology
• Small Molecules

Preferred Skills

• Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld)
• Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)

US and Puerto Rico Residents Only

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights (https://www.eeoc.gov/sites/default/files/2022-10/22-088_EEOC_KnowYourRights_10_20.pdf)

EEOC GINA Supplement

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts (https://www.msdprivacy.com/us/en/CCPA-notice/)

Primary Location

USA - Pennsylvania - West Point

Compensation

Where required by law, the compensation range for this role is provided below.

The salary range for the primary location of this role is:

$87,300.00 - $137,400.00

This range reflects the Company's reasonable expectation of the base salary applicable to this role at the time of posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits .

Additional location(s)

Please note the salary range above applies to the Primary Location of the position. Where a role has other listed locations, different compensation guidelines may apply. You may find the salary ranges for additional locations below. If the salary range is not listed for the location you are applying to, our Talent Acquisition team will provide further information to you relevant to your location.

Additional location(s) Compensation Information

San Francisco Residents Only

We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only

We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status

Regular

Relocation

Domestic

VISA Sponsorship

No

Travel Requirements

10%

Flexible Work Arrangements

Not Applicable

Shift

Not Indicated

Valid Driving License

No

Hazardous Material(s)

Biological matrices

Job Posting End Date

11/2/2026

A job posting is effective until 11:59:59PM on the day before the listed job posting end date. Please ensure you apply to a job posting no later than the day before the job posting end date.

Requisition ID

R423274