Scientist, Pharmacokinetics

MSD Malaysia; South San Francisco (CA); On-site; USD 108,000 - 170,000; Full time

Benefits offered by this job

Medical insurance

Dental and Vision coverage

401(k) retirement plan

Paid holidays and vacation

Sick days

Job summary

MSD Malaysia is seeking a collaborative scientist to support mass spectrometry-based immunogenicity assessment within the DMPK group. You will execute MAPPs studies, maintain human cell cultures, and perform immunoaffinity enrichment for LC-MS workflows, contributing to high-quality data alongside immunology, bioanalysis and MS experts.

The role emphasizes laboratory-based activities, sample preparation, instrument maintenance, and data integrity, with potential to present findings and

Qualifications

• Bachelor’s or Master’s in Biochemistry, Analytical Chemistry, Immunology, Cell Biology or related field with lab experience.
• Hands-on lab skills: pipetting, sample prep, buffer prep, documentation.
• Experience with IA or antibody-based enrichment techniques.
• Experience with LC-MS workflows and bioanalytical instrumentation.
• Experience maintaining mammalian cell cultures and routine benchwork.
• Familiarity with Orbitrap platforms and data acquisition software.
• Ability to document, analyze and interpret experimental data.
• Knowledge of MAPPs workflows and immunogenicity assessment is a plus.

Responsibilities

• Execute MAPPs experiments to support immunogenicity risk assessment.
• Maintain human cell cultures and prepare samples for analysis.
• Perform immunoaffinity enrichment workflows and LC-MS sample prep.
• Operate and troubleshoot Orbitrap-based LC-MS instrumentation.
• Generate and review high-quality experimental data per procedures.
• Help optimize sample prep workflows and automation initiatives.
• Maintain equipment, consumables, and lab records in compliance.

Skills

Antibodies

Biochemistry

Cell culture techniques

LC-MS

Mammalian cell culture

Mass spectrometry (MS)

Proteomics data analysis tools

Pipetting

Education

Bachelor’s or Master’s in Biochemistry/Immunology/Analytical Chemistry

Tools

Orbitrap mass spectrometry

Proteome Discoverer

MaxQuant

Chromatography systems

Job description

Job Description

Job Description The Drug Metabolism and Pharmacokinetics (DMPK) group within the PDMB function is seeking a highly motivated, collaborative scientist to support mass spectrometry-based immunogenicity assessment. The successful candidate will contribute to the execution of MHC-Associated Peptide Proteomics (MAPPs) studies and related LC-MS workflows used to characterize antigen presentation and support biologics, conjugates and peptides programs. The ideal candidate will primarily perform laboratory-based activities and be responsible for executing cell-based and immunoaffinity workflows, preparing samples for LC-MS analysis, maintaining laboratory instrumentation, and generating high-quality experimental data. The candidate will work in a multidisciplinary environment alongside scientists in immunology, bioanalysis, and mass spectrometry and will have opportunities to present findings at departmental meetings and contribute to scientific publications and presentations. In this exciting role, your primary activities will include:

Responsibilities

• Execute MAPPs (MHC-associated peptide proteomics) experiments to support immunogenicity risk assessment of therapeutic candidates.


• Maintain and expand human cell cultures, including routine cell maintenance, cell counting, viability assessment, and preparation of samples for downstream analysis.


• Perform immunoaffinity enrichment workflows, including antibody-based capture, antigen processing, and sample preparation for LC-MS analysis.


• Operate, maintain, and troubleshoot LC-MS instrumentation, including Orbitrap-based high-resolution mass spectrometry platforms.


• Generate, document, and review high-quality experimental data following established laboratory procedures and data integrity standards.


• Support optimization of sample preparation workflows and laboratory automation initiatives to improve efficiency and reproducibility.


• Maintain laboratory equipment, consumables, and records while ensuring compliance with safety and quality requirements.

Qualifications

• Education: Bachelor’s (with 3+ years) or Master’s in Biochemistry, Analytical Chemistry, Immunology, Cell Biology, Molecular Biology, Pharmaceutical Sciences or a related scientific discipline with relevant laboratory experience


• Required Experience and Skills: Hands-on experience with fundamental laboratory techniques, including pipetting, sample preparation, buffer preparation, and laboratory documentation


• Required Experience and Skills: Understanding of immunoaffinity (IA) or antibody-based enrichment techniques


• Required Experience and Skills: Experience operating or supporting LC-MS workflows and bioanalytical instrumentation


• Required Experience and Skills: Experience maintaining mammalian cell cultures and performing routine cell-based laboratory procedures


• Required Experience and Skills: Familiarity with high-resolution mass spectrometry (e.g., Orbitrap) platforms and associated data acquisition software


• Required Experience and Skills: Ability to collect, document, and analyze experimental data


• Required Experience and Skills: Understanding of research principles and experimental methodology


• Required Experience and Skills: Demonstrated attention to detail, organization, and commitment to generating high-quality scientific data


• Preferred Experience and Skills: Knowledge of MAPPs (MHC-associated peptide proteomics) workflows and immunogenicity assessment strategies


• Preferred Experience and Skills: Familiarity with Thermo Scientific Orbitrap mass spectrometry platforms, including Eclipse Orbitrap systems


• Preferred Experience and Skills: Experience with proteomics sample preparation, peptide characterization, and mass spectrometry-based proteomics workflows


• Preferred Experience and Skills: Experience with automated liquid handling systems, robotics, or laboratory automation platforms


• Preferred Experience and Skills: Experience using proteomics data analysis software such as Proteome Discoverer, MaxQuant, Genedata Expressionist, Peaks, or related tools


• Preferred Experience and Skills: Experience working in a pharmaceutical, biotechnology, or research-driven environment


• #EligibleforERP Required Skills: Antibodies, Biochemistry, Cell Culture Techniques, Laboratory Documentation, Liquid Chromatography-Mass Spectrometry (LC-MS), Mammalian Cell Culture, Mass Spectrometry (MS), Pharmacokinetics, Pipetting, Sample Preparations

Location / Eligibility

• San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance


• Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance


• Employee Status: Regular


• Relocation: Domestic


• VISA Sponsorship: No


• Travel Requirements: No Travel Required


• Flexible Work Arrangements: Not Applicable


• Shift: 1st - Day


• Valid Driving License: No


• Hazardous Material(s): N/A


• Job Posting End Date: 08/27/2026

Salary & Compensation

The salary range for this role is $108,000.00 - $170,100.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

Benefits

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days.

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Equal Opportunity & Diversity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.

As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds.

The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.

We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

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