Scientist, Peptide Chemistry

MBX Biosciences, Inc.; Burlington (MA); On-site; USD 120,000 - 170,000; Full time

Job summary

MBX Biosciences, Inc. in Burlington, MA, is seeking a Peptide Chemist to design, synthesize, and characterize novel peptides for drug discovery.

You will work under the Director of Chemistry in a collaborative, innovative environment, contributing to advancing peptide candidates with strong analytical support. The role requires experience in solid-phase peptide synthesis, HPLC, mass spectrometry, and strong teamwork, problem-solving, and leadership skills.

Qualifications

• PhD/MS in analytical chemistry, biochemistry, chemistry or related field (or BS with 2+ years relevant exp.).
• Demonstrated leadership, strong teamwork and problem-solving abilities.
• Ability to design, synthesize and characterize peptides; maintain detailed records.

Responsibilities

• Design, synthesize and characterize novel peptides for drug discovery.
• Perform solid-phase and solution-phase peptide syntheses; purify with HPLC.
• Characterize peptides using MS and other analytical techniques.
• Collaborate with biology, pharmacology, and formulation teams to advance candidates.

Skills

Leadership

Teamwork

Attention to detail

Problem-solving

Education

PhD or MS in Analytical Chemistry or Biochemistry or Chemistry

BS in Analytical Chemistry or Biochemistry or Chemistry with 2+ years experience

Tools

Solid-phase peptide synthesis

Solution-phase synthesis

HPLC

Mass spectrometry

Job description

Position Summary

MBX Biosciences is looking for a talented and motivated Peptide Chemist to join our dynamic research and development team. The successful candidate will be instrumental in designing, synthesizing, and characterizing novel peptides to support our drug discovery programs. Reporting to our Director of Chemistry, this position provides an excellent opportunity to work at the forefront of peptide therapeutics within a collaborative and innovative environment.

Key Responsibilities

• Synthesize peptides and peptide analogs using advanced techniques, such as solid-phase peptide synthesis and solution-phase synthesis. Experience with Solid-phase peptide synthesis is highly desirable.
• Perform the purification and characterization of peptides using HPLC, mass spectrometry, and other analytical techniques.
• Contribute to the design and modification of peptides to enhance pharmacological properties, including stability, bioavailability, and target specificity.
• Collaborate with cross-functional teams, including biology, pharmacology, and formulation scientists, to advance peptide candidates.
• Maintain accurate and detailed experimental records, and prepare technical reports and presentations.
• Maintain and support highly organized laboratory including consumables and reagent ordering and tracking
• Stay up to date with the latest advancements in peptide chemistry and related fields through literature reviews and participation in scientific conferences.

Education & Qualifications

• PhD or MS in Analytical Chemistry, Biochemistry, Chemistry, or a related field; or, BS in Analytical Chemistry, Biochemistry, Chemistry, or a related field with a minimum of 2 years of relevant experience.
• Demonstration of strong scientific and leadership skills that drive results.
• Must demonstrate excellent teamwork, attention to detail, and problem-solving abilities.
• Highly self-motivated, driven, can-do, make-it-happen attitude with the ability to own and drive projects.
• Strong collaborator with cross-functional teams and external partners
• Capable of continuous learning, open-minded, curious, highly organized, and detail-oriented

Travel

You will be expected to travel periodically based on the needs of the business to the extent requested by the Company including attendance at Together Weeks, Together Days and functional meetings as requested by the Company.

Company Overview

MBX Biosciences is a clinical-stage biopharmaceutical company headquartered in Carmel, Indiana, with a secondary office in Burlington, MA. Our mission is to transform the lives of people impacted by endocrine and metabolic disorders through our novel precision peptides.

Leveraging our proprietary Precision Endocrine Peptides (PEPs)™ platform, we are pioneering technology designed to overcome key limitations of existing therapies and enhance efficacy, tolerability, safety and convenience. Our team is advancing a pipeline of novel candidates with clinically validated targets, established endpoints for regulatory approval, and strong market potential.

Our pipeline includes canvuparatide (MBX 2108) for the treatment of chronic hypoparathyroidism, currently preparing for Phase 3 development, and a growing obesity portfolio that includes MBX 4291 in Phase 1 development, MBX 5765, a next-generation amycretin prodrug designed for once-monthly-dosing, as well as MBX 6180, a GLP/GIP/GCGR triple agonist prodrug for once monthly dosing; all of which optimize our PEP platform.

If you're passionate about advancing innovative treatments for patients and shaping the future of precision peptide therapeutics, this is your chance to make a real impact alongside a fast-paced, growing, mission-driven team. To learn more, visit our website mbxbio.com and follow us on LinkedIn

EEO Statement

MBX Biosciences is an Equal Opportunity Employer and is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.