Scientist, Molecular Assays

BioNJ Inc.; New Jersey; On-site; USD 90,000 - 130,000; Full time

Job summary

Legend Biotech is seeking a Scientist, Molecular Assays for the Bioanalytical Sciences team based in Somerset, NJ. The role focuses on developing and performing molecular biology assays including qPCR, ddPCR, and NGS workflows to support clinical, translational, and preclinical programs.

The ideal candidate has hands-on experience with nucleic acid extraction, library preparation, and data analysis, and can work independently in a fast-paced biotechnology environment while ensuring data quality

Qualifications

• Minimum 8+ years in life sciences with MS, or 3+ years with PhD.
• Hands-on nucleic acid extraction, qPCR, RT-qPCR, or ddPCR.
• Experience with NGS workflows and library preparation; single-cell sequencing a plus.
• Familiarity with assay development, data analysis, and sample processing.
• Experience in cell and gene therapy, immunology, oncology, or regulated labs.
• Strong attention to detail and documentation.

Responsibilities

• Perform molecular biology experiments supporting diverse research programs.
• Execute qPCR and ddPCR assays for gene expression, biomarkers, and biodistribution.
• Support assay development, transfer, and troubleshooting.
• Perform nucleic acid extraction, quantification, and quality assessment.
• Prepare samples and library prep for NGS, including single‑cell RNA sequencing.
• Operate and maintain qPCR, ddPCR, and NGS platforms.
• Analyze data, ensure quality, document protocols and reports.
• Track and manage samples using LIMS and ELN.
• Support lab operations, inventory, equipment, and organization.
• Contribute to continual workflow and assay improvements.

Skills

Molecular biology

qPCR

RT-qPCR

ddPCR

NGS library prep

Single-cell sequencing

Data analysis

Sample processing

Assay development

Lab safety

Education

M.S. in Life Sciences or related field

Ph.D. in related field

Tools

qPCR instruments

ddPCR platforms

NGS platforms

LIMS

ELN systems

Job description

Legend Biotech is seeking a Scientist, Molecular Assays as part of the Bioanalytical Sciences team based in Somerset, NJ.

Role Overview

We are seeking a highly motivated scientist to join our Bioanalytical Sciences team. This position will support the development, execution, and optimization of molecular assays for clinical, translational, and preclinical programs. The successful candidate will contribute to a broad range of molecular biology activities, with primary responsibilities focused on quantitative PCR (qPCR), digital droplet PCR (ddPCR), and next‑generation sequencing (NGS), including single‑cell sequencing workflows.

The ideal candidate will have hands‑on experience with molecular biology techniques, strong laboratory execution skills, and exceptional attention to detail. Experience with qPCR, ddPCR, nucleic acid extraction, NGS library preparation, and biological sample processing is highly desirable. This role offers an excellent opportunity for an early‑career scientist to work in a fast‑paced biotechnology environment supporting innovative cell and gene therapy programs while collaborating with multidisciplinary teams across research and development.

Key Responsibilities

• Perform molecular biology experiments supporting clinical, translational, and preclinical research programs.
• Execute qPCR and ddPCR assays for gene expression analysis, biomarker quantification, transgene detection, vector copy number determination, and biodistribution studies.
• Support development, optimization, qualification, transfer, and troubleshooting of molecular assays.
• Perform nucleic acid extraction, quantification, and quality assessment from blood, tissue, cell culture, and other biological samples.
• Prepare samples and perform library preparation for next‑generation sequencing (NGS) applications, including single‑cell RNA sequencing (scRNA‑seq).
• Operate and maintain molecular biology instrumentation, including qPCR, ddPCR, and NGS‑related platforms.
• Analyze experimental data, ensure data quality, maintain accurate laboratory documentation, and assist in the preparation of protocols, SOPs, technical reports, and assay‑related documents.
• Process, track, and manage biological samples using LIMS and ELN systems while ensuring sample integrity and traceability.
• Support laboratory operations, including inventory management, sample shipments, equipment maintenance, and laboratory organization.
• Contribute to the continuous improvement of laboratory workflows, assay performance, and operational efficiency.

Requirements

• M.S. in Life Sciences, Molecular Biology, Biochemistry, or a related field with 8+ years of relevant experience, or Ph.D. in a related scientific discipline with 3+ years of relevant experience.
• Hands‑on experience with molecular biology techniques, including nucleic acid extraction, qPCR, RT‑qPCR, and/or ddPCR.
• Experience with NGS workflows and library preparation; single‑cell sequencing experience is a plus.
• Familiarity with assay development, data analysis, and biological sample processing.
• Experience in cell and gene therapy, immunology, oncology, or regulated laboratory environments is desirable.
• Strong attention to detail, organization, and documentation skills.
• Excellent analytical, problem‑solving, and communication skills.
• Ability to work independently and collaboratively in a fast‑paced laboratory environment.
• Commitment to data quality, laboratory safety, and continuous learning.
• Work in a clinical, research, pharmaceutical, or diagnostic laboratory.
• May require standing for extended periods and lifting up to 25 pounds.
• Use of personal protective equipment (PPE) is required.
• Involve handling biological specimens and hazardous materials following safety guidelines.

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life‑threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in‑vivo cell therapy approaches. Our research spans chimeric antigen receptor T‑cell (CAR‑T), T‑cell receptor (TCR‑T), natural killer (NK) cell‑based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting‑edge therapies for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta‑cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.

Please note: These benefits are offered exclusively to permanent full‑time employees. Contractors are not eligible for benefits through Legend Biotech.

Work Authorization & Employment Eligibility

Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E‑Verify program. If you are selected for employment, you will be required to complete the Form I‑9 process, and your employment eligibility will be verified through E‑Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at‑will and may be terminated at any time with or without cause or notice by the employee or the company.

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