Scientist, In Vivo Process Development Downstream

Kite Pharma, Inc.; Philadelphia (Philadelphia County); Híbrido; USD 133.000 - 172.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Discretionary annual bonus

Stock-based long-term incentives

Paid time off

Benefits package (medical, dental, vis

Descripción de la vacante

Kite Pharma, Inc. is seeking a Scientist for In Vivo Process Development Downstream in Philadelphia, PA to design and optimize downstream purification for Lentivirus. You will lead scalable processes, ensuring scientific rigor and robust performance while mentoring teammates.

The role requires strong chemistry/biochemistry foundations, cGMP experience, and the ability to work with cross-functional teams to improve process performance and scalability.

Formación

• Hands-on proficiency of downstream unit operations for large biomolecules (e.g. protein, virus)
• Experience with bioprocess scale-up for large biomolecules
• Working knowledge of cGMP principles
• Proficiency in Word, Excel, PowerPoint, and data analysis software (JMP, GraphPad)
• Ability to collaborate in a dynamic team and communicate results clearly

Responsabilidades

• Design and optimize scalable downstream processes for Lentivirus manufacturing
• Provide technical solutions to complex problems using advanced scientific and engineering principles
• Support manufacturing activities and process optimization at scale
• Manage day-to-day laboratory operations and documentation
• Train and mentor colleagues in process execution and troubleshooting
• Communicate technical outcomes in reports and presentations
• Collaborate across multidisciplinary groups to solve issues

Conocimientos

Downstream unit operations

Bioprocess scale-up

cGMP knowledge

DOE (Design of Experiments)

Statistical data analysis

Mentoring/leadership

Communication skills

Lab documentation

Educación

BS/MS/PhD in science or engineering

Biotechnology/bioprocess experience

Herramientas

JMP

GraphPad

Descripción del empleo

Scientist, In Vivo Process Development DownstreamSkip to main content#Scientist, In Vivo Process Development Downstream page is loaded## Scientist, In Vivo Process Development DownstreamApplyremote type: Onsite Requiredlocations: United States - Pennsylvania - Philadelphiatime type: Full timeposted on: Posted Yesterdaytime left to apply: End Date: July 31, 2026 (30+ days left to apply)job requisition id: R0052862We’re here for one reason and one reason only – to cure cancer. Every moment is dedicated to developing treatments and every action moves us one step closer to our goal. We’ve made incredible scientific breakthroughs and our pioneering personalized CAR T-cell therapies have changed the paradigm. But we're not finished yet.Join Kite, as we make even bigger advances in cancer therapies, and help shape where our business and medical science goes next.We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Kite and help create more tomorrows.## Job DescriptionThe **Scientist, In Vivo Process Development Downstream** role designs and executes downstream/purification experiments to support development of manufacturing processes for Lentivirus.This role applies advanced chemistry, biochemistry, and/or engineering principles to deliver robust, scalable processes, supports manufacturing activities and process optimization at scale, and operates with broad autonomy and limited oversight. The Scientist is accountable for end-to-end process performance, scientific soundness, and technical leadership while training and mentoring colleagues.**Key Responsibilities*** Design and optimize scalable, safe, and cost-effective downstream process for Lentivirus manufacturing.* Develops technical solutions to complex problems requiring ingenuity and creativity, applying advanced scientific/engineering principles to ensure scientific soundness and performance.* Supports manufacturing activities and process optimization at scale, contributing technical expertise to improve process performance and scalability.* Manages day-to-day laboratory operations, including planning work, maintaining efficient lab execution, and ensuring effective documentation practices.* Keep accurate, detailed laboratory records and comply to all required training and safety guidelines.* Apply statistical methodologies and basic modelling approaches to design experiments, perform data analysis, and interpret data.* Trains, guides, and mentors colleagues by sharing technical skills, coaching on process execution, and troubleshooting, and strengthening team capability.* Communicates technical outcomes in technical reports and presentations* Interface with multidisciplinary groups to solve complex issues and promote collaboration.* Works independently with broad autonomy and limited oversight; determines approaches for moderately complex assignments under minimal direction.**Education and Experience*** B.S., M.S, PhD/PharmD in science or engineering* BS with 6+ years post-graduate relevant experience in bioprocess/biotechnology, or* MS with 4+ years post-graduate relevant experience in bioprocess/biotechnology, or* PhD/PharmD**Required Qualifications*** Must have strong scientific understanding and demonstrated hands-on proficiency of downstream unit operations for large biomolecules (e.g. protein, virus) such as chromatography and filtration.* Sound understanding of bioprocess scale-up principles for large biomolecules* Working knowledge of cGMP principles* Proficiency in Microsoft Word, Excel, Power Point, and data analysis software such as JMP, GraphPad* Proven ability to collaborate in a dynamic team environment* Excellent interpersonal, verbal, and written communication skills* Strong organization and problem-solving skills with excellent attention to details**Preferred Experience and Skills*** Prior experience with process development of viral vectors* Prior experience with the use of Design of Experiments (DOE) to support process development experiments.* Prior experience with fermentation/cell culture and analysis of large biomolecules* Hands-on experience with large scale bioprocessing in either non-GMP or GMP setting* Demonstrated mentorship and team leadershipThe salary range for this position is: $133,195.00 - $172,370.00. Kite considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans\\*.For additional benefits information, visit:https://www.gilead.com/careers/compensation-benefits-and-wellbeing\\* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors. Kite is based in Santa Monica, CA. For more information on Kite, please visit www.kitepharma.com. Sign up to follow @KitePharma on Twitter at www.twitter.com/kitepharma.