Scientist, In Vivo Pharmacology (Night Shift)

Capable; San Francisco, Northern (CA, KY); Hybrid; USD 75,000 - 110,000; Full time

Benefits offered by this job

Equity options

Wellness budget

Comprehensive healthcare

HSA/FSA/401K

Daily team dinners

Visa sponsorship available

Job summary

Capable Labs in San Francisco is seeking to fill a night-shift role performing in vivo mouse studies to support therapeutic candidate evaluation. You will manage overnight dosing, sample collection, data organization, and handoffs to the day team to ensure rapid interpretation of results.

The ideal candidate has prior hands-on mouse study experience in biotech, pharma, or academia, with comfort in diverse dosing routes and adherence to protocols.

Qualifications

• Able and willing to work the designated night-shift schedule reliably and operate independently when needed.
• Hands-on experience running mouse studies in biotech, pharma, academia, or a closely related setting.
• Comfort with common dosing routes, animal handling, sample collection, accurate records, and protocol-compliant in vivo execution.
• Experience with surgeries, EEG procedures, intranasal dosing, or other specialized methods is helpful; you do not need experience with every procedure listed.
• Sound judgment, careful attention to animal welfare and data quality, and a habit of documenting and communicating issues early.
• The ability to create clean, useful handoffs for scientists interpreting the study and planning what comes next.

Responsibilities

• Run overnight portions of mouse studies evaluating safety and effectiveness of therapeutics.
• Dose mice via IP, IV, SC, PO, and intranasal routes per study designs and training.
• Collect blood and tissues; properly label, track, process, and store samples for analysis.
• Perform or support surgeries and specialized in vivo procedures, including EEG surgeries and EEG-study execution.
• Monitor study conduct and animal welfare, document observations and deviations, and elevate protocol-based decisions during overnight hours.
• Perform routine vivarium duties such as cage care, bedding changes, restocking, and health monitoring.
• Organize dosing, procedures, samples, and health data so the study record is complete and interpretable.
• Provide clear morning handoffs covering completed work, results, issues, samples, and follow-up recommendations.

Skills

Night-shift work

Mouse studies experience

Animal handling

Record-keeping

Handoffs to scientists

Tools

EEG procedures

Job description

We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber. We value speed and rigor, coupled with excitement, drive, and a strong work ethic. In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.

Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better. You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems.

We believe excellent work should be met with meaningful reward, ownership, and trust. Responsibility is earned through contribution, not title alone: anyone who demonstrates the judgment, rigor, and follow-through to move important work forward can earn meaningful scope.

About the Role

You will execute mouse studies on a dedicated night-shift schedule, enabling overnight dosing, collections, procedures, and continuous study coverage. You will perform in vivo work carefully and independently, organize samples and data, support specialized procedures including EEG studies, and provide complete handoffs that allow the day team to interpret results and move quickly.

Responsibilities

• Run overnight portions of mouse studies evaluating therapeutic candidates for safety and effectiveness.

• Dose mice using routes such as IP, IV, SC, PO, and intranasal administration in accordance with study designs, protocols, and your training.

• Collect blood and disease-relevant tissues; prepare, label, track, process, and store samples correctly for downstream analysis.

• Perform or support surgeries and specialized in vivo procedures, including EEG surgeries and EEG-study execution where required.

• Monitor study conduct and animal welfare, document observations and deviations, and make or elevate protocol-based decisions during overnight hours.

• Perform routine vivarium duties as needed, including cage care, bedding changes, supply restocking, and animal-health monitoring.

• Organize dosing, procedure, sample, and animal-health data so that the study record is complete and interpretable.

• Provide clear morning handoffs covering completed work, results, issues, samples, and recommended follow-up.

Ideal Qualifications

• Able and willing to work the designated night-shift schedule reliably and operate independently when needed.

• Hands-on experience running mouse studies in biotech, pharma, academia, or a closely related setting.

• Comfort with common dosing routes, animal handling, sample collection, accurate records, and protocol-compliant in vivo execution.

• Experience with surgeries, EEG procedures, intranasal dosing, or other specialized methods is helpful; you do not need experience with every procedure listed.

• Sound judgment, careful attention to animal welfare and data quality, and a habit of documenting and communicating issues early.

• The ability to create clean, useful handoffs for scientists interpreting the study and planning what comes next.

Pay & Benefits

• In addition to the posted salary range, we offer generous equity options.

• Compensation will depend on the skills, experience, and scope of impact you bring. If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.

• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.

• Healthcare: We offer a broad range of medical, dental, and vision coverage options, with Capable covering 100% of the base policy.

• You will also have access to HSA, FSA, and 401K plans.

• Healthy dinners with the team are provided daily.

• We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways. Our team is already international, with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.

Equal Opportunity

Capable is an Equal Opportunity Employer; employment with Capable is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status.