Scientist II, Bioanalytical and Biomarker Development

Wave Life Sciences; Lexington (MA); On-site; USD 135,000 - 182,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

Life insurance

Disability insurance

Generous paid time off

401K with matching

Employee Stock Purchase Program

Job summary

Wave Life Sciences seeks a Scientist II to advance bioanalytical and biomarker development in Lexington, MA. The role supports clinical programs by delivering robust bioanalytical data and reports for toxicology and PK studies, and by aiding target engagement analyses in preclinical settings.

The ideal candidate has a BS/MS with 8+ years in industry, hands-on experience with LC-MS/MS, MSD, ELISA, and nucleic acid assays, and a proven ability to work in a fast-paced biotech startup environment.

Qualifications

• BS/MS with 8+ years industry experience.
• Experience with oligo bioanalysis in biological matrices.
• Ability to transfer assays to CROs and manage CRO work.
• Strong written and oral communication skills.

Responsibilities

• Develop and qualify bioanalytical assays (LC-MS/MS, MSD, ELISA) for oligos.
• Analyze samples in blood, plasma, tissue; support tox, PK studies.
• Plan experiments and drive efficient assay development for studies.
• Transfer methods to CROs and supervise their work.
• Prepare clear experimental reports and data presentations.

Skills

Bioanalytical assay development

Data analysis

SOP writing

Team collaboration

Bioanalytical CRO oversight

Education

B.S./M.S. in life sciences

Tools

LC-MS/MS

MSD

ELISA

RT‑PCR/qPCR

Job description

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description

Wave Life Sciences is seeking a highly motivated individual to join the Preclinical and Clinical Development Sciences team in Lexington, Massachusetts. The Scientist II, Bioanalytical and Biomarker Development will support the clinical stage program teams aiming to deliver bioanalytical data and reports, which directly support toxicology, PK/PD studies in preclinical settings through clinical studies. In addition, this individual will support target engagement, PK/PD and tolerability studies in preclinical settings.

Experience

• B.S. / M.S. and 8 or more years relevant experience in industry

Responsibilities

May include some or all of the following:

• Perform method development and qualifications for oligos in biological matrix using LC-MS/MS, MSD and/or ELISA based assays
• Perform sample analysis according to established method protocols in different biological matrix, e.g. blood, plasma, tissue etc.
• Involved in planning experimental design and execution of all aspects of bioanalysis, efficient assay development to support investigative Tox and PK studies
• Transfer methods to CROs and manage their work
• Adept at preparation of clear and accurate reports for internal and external projects
• Prepare clearly articulated experimental reports and data presentations

Key Skills

• Hands on experience across bioanalytical and biomarker assay development and qualification using multitude of bioanalytical methods (i.e., ELISA, MSD, LC-MS, RT-PCR, qPCR, and cell-based assays) to support discovery, preclinical and potential clinical projects
• Experience with transfer of assays to CROs (or prior experience within bioanalytical CROs) and troubleshooting technical issues
• Ability to independently analyze data and present and share the data with the stakeholders
• Conversant with writing SOPs and other technical reports as needed
• Experience within a start-up or small biotech environment
• Excellent organizational and communication skills, with an ability to embrace change and multi-task in an extremely fast paced environment
• Excellent problem-solving skills and ability to work as a team player in a dynamic environment

Pay Range Disclosure Statement: $135,000 USD - $182,000 USD

The range provided is based on what we believe is a reasonable estimate for the annual base salary pay range for this position at the time of posting. Actual annual base salary will vary based on several factors including, but not limited to, relevant skills, experience, qualifications, position criticality, and internal equity. This position is eligible for a discretionary annual bonus and discretionary stock-based long-term incentives.

In addition to compensation, Wave offers a comprehensive and competitive range of benefits designed to support our employees’ and their families physical and financial health and overall well-being.

• company-sponsored medical
• dental
• vision
• life
• long and short-term disability insurances
• generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• 401K participation with matching contributions
• Employee Stock Purchase Program

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.

Data Privacy and Your Information

By submitting your information in applying for a position at Wave (or lawfully on behalf of a candidate as an approved recruiter), you represent that the information you submit (including your name, phone number, email address, address, and resume/CV/work history) is true and accurate, you have the right to share it, and that no part of the Information violates or infringes the rights of any third parties. If you submit information lawfully on behalf of another applicant as an approved recruiter, you confirm that you have the right to so submit.

You grant Wave permission to use your information to contact you in connection with this or another position, for interviews, scheduling purposes, travel arrangements, or follow up after a decision on the role has been made.

Wave Life Sciences is committed to respecting your privacy. We do not sell or rent personal information to third parties for marketing purposes.Any Personal Information you share with us will be used for business purposes, such as communication with you, and handled in accordance with Wave’s Privacy Policy, Notice, Statements, and Additional Information. Wave collects, evaluates and retains candidate data for the legitimate interest of selecting a candidate for employment or contract purposes. Such data will be kept for no longer than necessary to carry out those purposes, unless you consent for your information to be retained up to an additional three (3) years for consideration for future opportunities at Wave. Any requests related to your Personal Information may be electronically submitted to Wave’s Data Protection Officer at https://wavelifesciences.com/privacy/.

If you choose to share your demographic background (such as race, gender or sex, national origin, age, disability or veterinary status) by completing the optional survey, your responses will be combined with the answers from other applicants in an aggregated and anonymized form which may be used for equal employment opportunity reporting, diversity and inclusion analysis, and to help us evaluate the effectiveness of our recruiting practices. The information you share will not be used for hiring decisions or provided to hiring managers or interviewers.