Scientist II

Dana-Farber Cancer Institute (DFCI); Boston (MA); On-site; USD 85,000 - 105,000; Full time

Job summary

Dana-Farber Cancer Institute in Boston, MA is seeking a Scientist II in the Freed-Pastor Laboratory to join the Cancer Grand Challenges—Team ILLUMINE, focusing on exploring the Cancer Dark Proteome and advancing innovative cellular therapies for pancreatic cancer.

This hands-on bench role emphasizes rigorous data generation, experimental execution, and collaboration across a multi-institutional team, with ownership of essential laboratory operations and contribution toward clinical trial

Qualifications

• Advanced degree preferred.
• Six to nine years experience post undergraduate degree.
• One to two year work experience post education.

Responsibilities

• Independently design, execute, and analyze experiments focusing on discovery and characterization of T-cell receptors (TCRs) and chimeric antigen receptors (CARs).
• Conduct rigorous ex vivo and in vivo preclinical studies of lead cellular therapy candidates with meticulous data collection and analysis.
• Establish and utilize patient-derived organoids and patient-derived xenografts for antigen discovery and preclinical testing.
• Perform rigorous data analysis, interpretation, and presentation of results at lab meetings; contribute to manuscripts and conference presentations.
• Demonstrate technical proficiency, creativity, collaboration, and independent thought on problems of moderate to large scope.
• Work with minimal supervision and maintain wide latitude for independent judgment.

Education

Advanced degree (preferred)

Six to nine years experience post undergraduate

One to two year work experience post education

Job description

Scientist II

Dana-Farber Cancer Institute

Boston, MA

Full Time

Overview

The Scientist II works on complex projects related to the field with minimal supervision. Has a wide latitude for independent judgement and may assist less-experienced peers. Works on problems of moderate to large scope in which analysis of situation or data requires a review of identifiable factors. Exercises judgment within defined procedures and practices to determine appropriate action. Contributes technical proficiency and scientific creativity. Works both collaboratively and independently.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

The Freed-Pastor laboratory at Dana-Farber Cancer Institute is seeking an exceptionally motivated and experienced PhD-level scientist (Scientist II) to join Cancer Grand Challenges - Team ILLUMINE to investigate the Cancer Dark Proteome and drive the development of innovative cellular therapies for pancreatic cancer. This position is primarily a hands-on bench role focused on rigorous data generation and direct experimental execution. In addition to bench work, the ideal candidate will take ownership of essential laboratory operations and coordinate efforts across this multi-institutional team. The successful candidate will be integral to a multidisciplinary team focused on the discovery, preclinical evaluation, and advancement towards clinical trials of novel immunotherapies.

Primary Duties and Responsibilities

• Demonstrates potential for technical proficiency, scientific creativity, collaboration with others and independent thought.
• Works on problems of moderate to large scope in which analysis of situation or data requires a review of identifiable factors.
• Exercises judgment within defined procedures and practices to determine appropriate action.
• Works under minimal supervision. Wide latitude for independent judgment
• Independently design, execute, and analyze experiments focused on the discovery and characterization of T-cell receptors (TCRs) and chimeric antigen receptors (CARs)
• Conduct rigorous ex vivo and in vivo preclinical studies of lead cellular therapy candidates. This includes meticulous data collection and analysis.
• Establish and utilize patient-derived organoids and patient-derived xenografts for antigen discovery and preclinical testing
• Perform rigorous data analysis, interpretation, and presentation of experimental results at laboratory meetings, and contribute to the preparation of manuscripts and presentations at scientific conferences.

Knowledge, Skills and Abilities

• Highly-skilled with extensive proficiency. Works on complex projects related to field.

Minimum Job Qualifications

• Advanced degree preferred.
• Six to nine years experience post undergraduate degree.
• One to two year work experience post education.

License/Certification/Registration Required:

None

Supervisory Responsibilities:

• May assist less-experienced peers.

Patient Contact:

None

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionate professionals, neither do we.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

Pay Transparency Statement

The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications.

For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).

$85,000.00 - $104,650.00