Scientist – Electrochemical Enzyme Assay Development and Testing

Arzeda; Seattle (WA); On-site; USD 101,000 - 140,000; Full time

Benefits offered by this job

Comprehensive compensation package

Excellent medical, dental, and vision insurance

401(k) retirement savings plan

Commuter benefits

Job summary

Arzeda in Seattle is seeking a Scientist to join their Protein Testing Team, focusing on enzyme assay development. The successful candidate will utilize their knowledge of electrochemistry and biochemistry to contribute to innovative enzyme engineering projects.

This role demands a Ph.D. or equivalent experience, emphasizing high-throughput assays, and offers a competitive salary between $101,000 and $140,000 based on experience.

Qualifications

• Ph.D. in Bioelectrocatalysis, Biocatalysis, Biochemistry, Chemistry, or related field.
• In-depth knowledge and hands-on experience with enzyme characterization.
• Experience developing enzyme assays for biocatalysis or bioconversions.

Responsibilities

• Develop robust high throughput enzyme assays for bioelectro-conversions.
• Evaluate enzyme performance using electrochemical and traditional assays.
• Design and optimize automation-compatible assay workflows.

Skills

Enzyme characterization

High-throughput assay development

Electrochemistry

Analytical biochemistry

Data analysis

Python

R

Education

Ph.D. in relevant field or 4+ years experience

Tools

HPLC

Automation equipment

Job description

Scientist – Electrochemical Enzyme Assay Development and Testing

We are seeking a detail-oriented Scientist to join our highly collaborative Protein Testing Team. You will play a critical role in the continued development of our enzyme engineering platform to rapidly screen and optimize enzyme functions by developing high-throughput, automation-ready assay workflows that accelerate enzyme screening, characterization, and experimental iteration.

Using your deep knowledge of electrochemistry, enzymology, enzyme kinetics, protein characterization, analytical biochemistry, and high-throughput assay development and troubleshooting you will contribute to impactful projects across the company.

Location

Seattle, Washington

Responsibilities

• Develop robust high throughput enzyme assays for bioelectro-conversions or bioconversions.
• Evaluate enzyme performance using electrochemical assays, and traditional enzyme assays, using absorbance, fluorescence, and HPLC/MS to detect and quantify products, cofactors, and reaction mediators.
• Contribute to and become an owner of experimental design to drive efficient identification of enzymes with desired properties.
• Perform cell-free expression, and high-throughput or mid-scale protein preparation, as needed.
• Design, optimize, and scale automation-compatible assay workflows to increase experimental throughput, reproducibility, and data quality.
• Partner with automation, software, and data infrastructure teams to implement robotic liquid handling, assay orchestration, and streamlined data analysis pipelines.
• Identify experimental bottlenecks and develop strategies to reduce assay cycle time and increase design-build-test-learn iteration speed.
• Develop, optimize, and perform laboratory SOPs.
• Interface with upstream and downstream teams for efficient data exchange and transfer of materials.
• Operate and maintain electrochemistry equipment.

Qualifications

• Ph.D. in Bioelectrocatalysis, Biocatalysis, Biochemistry, Chemical Biology, Chemistry or other related field, or 4+ years of experience in a Masters or industry role.
• In-depth knowledge and hands‑on experience with enzyme characterization.
• Experience developing enzyme assays, especially for biocatalysis or bioconversions.
• Experience designing or operating automated experimental workflows and high-throughput assay systems strongly preferred.
• Understanding of redox chemistry and thermodynamics.
• Experience developing and characterizing enzymes and enzyme‑electrode interfaces including direct and/or mediated electron transfer using spectroscopic and electrochemical methods.
• Understanding of Marcus and Butler‑Volmer theory pertaining to electrocatalysis, ideally also familiar with hydride transfer theory and electrochemical impedance spectroscopy.
• Experience working in a glovebox or bag.
• Experience evaluating data sets, reporting, and presenting findings from data analysis.
• Desire to communicate openly within a team and be receptive to feedback and learning opportunities.
• Adaptable to changing plans as needed to meet goals.

Nice-to-haves

• Python and/or R.
• Hands‑on experience with automation equipment.
• Understanding of HPLC or LC/MS for small molecules and proteins.

Compensation and Benefits

• Base salary of $101,000 to $140,000 depending on experience.
• Comprehensive compensation package, to include equity.
• Paid time off; company-observed holidays to include a company paid holiday closure between Dec 25 and Jan 1; and paid medical/family leave.
• Excellent medical, dental, and vision insurance to include options for Health Savings Accounts.
• 401(k) retirement savings plan.
• Commuter benefits.

Equal Opportunity Employer

Arzeda is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and expression), sex (including pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.