Scientist - Aviner/Andino labs

UCSF Health, AG; San Francisco (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

UCSF Health is seeking a full-time Scientist to lead an experimental program at the intersection of RNA biology, high-throughput functional genomics, and molecular virology. Immediate start for a fully funded 2-year project.

Location: On-site at UCSF Mission Bay, San Francisco, CA. You will design, execute, and interpret MPAs, perform library construction and RNA synthesis, and translate results into viral attenuation candidates.

Qualifications

• Ph.D. in Molecular Biology, Biochemistry, Microbiology or related field.
• Deep technical command of RNA workflows from data collection to analysis.
• Independent problem solver: you’ve taken a messy experimental problem from idea to clean data without someone telling you how.
• Preferred: experience with high-throughput reporter or CRISPR screens, molecular virology, neuronal cultures.

Responsibilities

• Design, construction, and execution of massively parallel reporter assays (MPRAs) to measure cell type-specific translation dynamics
• End-to-end wet lab execution: library construction, in vitro RNA synthesis, delivery into human cell cultures, and NGS quantification
• Translating high-throughput screen outputs directly into targeted viral attenuation candidates

Skills

RNA workflows

Data analysis

Independent problem solving

High-throughput screens

Education

PhD in Molecular Biology, Biochemistry, Microbiology or related field

Job description

Can we make live vaccines safer by controlling how a virus is translated in specific cell types?

We’re hiring a full-time Scientist to lead an experimental program at the intersection of RNA biology, high-throughput functional genomics, and molecular virology.

The project

A fully funded 2-year effort focused on rational viral genome engineering and cell type-specific translational control to develop live-attenuated vaccines.

Location

On-site at UCSF Mission Bay (San Francisco, CA)

Start Date

Immediate

What you’ll own

• Design, construction, and execution of massively parallel reporter assays (MPRAs) to measure cell type-specific translation dynamics
• End-to-end wet lab execution: library construction, in vitro RNA synthesis, delivery into human cell cultures, and NGS quantification
• Translating high-throughput screen outputs directly into targeted viral attenuation candidates

Who you are

• Ph.D. in Molecular Biology, Biochemistry, Microbiology or related field
• Deep technical command of RNA workflows from data collection to analysis
• Independent problem solver: y ou’ve taken a messy experimental problem from idea to clean data without someone telling you how
• Preferred but not required: experience with high-throughput reporter or CRISPR screens, molecular virology, neuronal cultures