Scientist Analytical Development

Moderna Therapeutics; Norwood (MA); On-site; USD 109,000 - 175,000; Full time

Benefits offered by this job

Best-in-class health care coverage

Well-being resources including fitness and mental health support

Generous paid time off and global recharge days

Job summary

<p>Moderna Therapeutics is seeking a Scientist for its Analytical Development team in Norwood, MA. This full-time role involves developing analytical methods and collaborating across functions for therapeutic programs. The position requires on-site presence and seeks candidates with a PhD or an MS degree with significant relevant experience.</p><p>The successful candidate will contribute to advanced method development, optimization, and documentation, ensuring compliance with regulatory standards. A competitive salary and comprehensive benefits are offered.</p>

Qualifications

• PhD with 0-2 years or MS with 5+ years of industry experience in Analytical Chemistry or related.

Responsibilities

• Develop and execute analytical methods for plasmid, mRNA, and LNP.
• Collaborate cross-functionally to support method development.
• Document experimental work and maintain LC-MS instrumentation.

Skills

LC-MS

HPLC

Technical writing

Data analysis

Organizational skills

Communication skills

Education

PhD in Analytical Chemistry or related discipline

MS with 5+ years of relevant industry experience

Tools

Mass spectrometry

UV/Vis Spectroscopy

MS data analysis software (Xcalibur, MassHunter)

Job description

Overview

Moderna is seeking a Scientist for the Analytical Development team in Norwood, MA. The role focuses on advanced analytical method development, optimization, and implementation to support therapeutic and vaccine programs. The position is full‑time and requires on‑site presence.

Key Responsibilities

• Develop and execute analytical methods, including mass spectrometry and HPLC with various detector configurations, to assess plasmid, mRNA, and LNP products.
• Perform intact mass analysis and primary structure characterization of proteins.
• Develop LC‑MS/MS methods for qualitative and quantitative protein analysis.
• Create feasibility data and support method development, optimization for novel platforms such as new plasmid manufacturing approaches and oncology programs.
• Collaborate cross‑functionally with Research Analytics, Process Development, Quality Control, and Analytical Technical Operations to support method development, qualification, investigations, and technology transfer.
• Document experimental work in electronic lab notebooks and author technical reports, summaries, and method implementation documents.
• Maintain and troubleshoot LC‑MS instrumentation, including Orbitrap, Q‑TOF, and triple quadrupole systems.
• Ensure quality and data integrity in compliance with internal standards and regulatory expectations.

Basic Qualifications

• PhD with 0‑2 years or MS with 5+ years of relevant industry experience in Analytical Chemistry, Biochemistry, Chemistry, or a related discipline.
• 4‑5 years hands‑on experience in LC‑MS, HPLC, UV/Vis, spectroscopy, and MAM workflows.
• Proficiency in MS data analysis software (Xcalibur, MassHunter, Skyline, Biopharma Finder, Protein Metrics).
• Demonstrated ability to perform method development, troubleshooting, and data analysis for biologics, RNA, or complex formulations.
• Familiarity with regulatory guidance, method transfer, and collaboration with Quality in a regulated environment.
• Knowledge of LNP characterization or nucleic acid‑based analytical methods is a plus.
• Strong technical writing and documentation skills.
• Excellent organizational, multitasking, and communication skills for fast‑paced environments.
• Self‑motivated, scientifically curious, and able to work independently with minimal supervision.

Location and Work Model

The position is site‑based at Moderna’s Norwood, MA facility. Remote work is not available.

Benefits

• Competitive salary range: $109,200.00 – $174,600.00.
• Best‑in‑class health care coverage and voluntary benefit programs.
• Well‑being resources including fitness, mindfulness, and mental health support.
• Family planning benefits, including fertility, adoption, and surrogacy support.
• Generous paid time off, volunteer days, sabbatical, global recharge days, and discretionary year‑end shutdown.
• Savings and investment opportunities.
• Location‑specific perks and extras.

Equal Employment Opportunity

Moderna is an equal‑employment‑opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex or gender, gender identity or expression, sexual orientation, national origin, age, disability, or any other protected status.