Scientist 3

F. Hoffmann-La Roche AG; San Diego (CA); On-site; USD 90,000 - 167,000; Full time

Benefits offered by this job

Discretionary annual bonus

Genentech benefits package

Job summary

Genentech in San Diego, CA seeks a Scientist 3 to independently execute and optimize synthesis of lipid nanoparticles (LNPs) encapsulating nucleic acids for in vitro and in vivo studies. You will lead DoE-based screening campaigns and collaborate with biology, analytics, chemistry, and project management teams.

You will support early-stage formulation development, downstream processing, including cryoprotection, scale-up, stability studies, and data interpretation.

Qualifications

• PhD with relevant experience or Master’s with 3+ years in biopharma.
• 2+ years hands-on LNP formulation and encapsulation work.
• Proficient with LNP characterization methods (DLS, Zeta, Ribogreen).

Responsibilities

• Execute and optimize synthesis of LNPs for nucleic acid delivery.
• Lead DoE-based screening campaigns to define LNP composition.
• Collaborate cross-functionally to advance formulation programs and support scale-up.

Skills

LNP formulation

DoE-based screening

Data analysis (Excel, JMP, Prism)

MS Excel

Technical report writing

Communication across teams

Education

PhD in Chemistry/Biochemistry/Chemical Engineering or related with industry experience

Master’s in Chemistry/Biochemistry/Chemical Engineering or related with 3+ years industry experience

Tools

DLS

Zeta potential

Ribogreen assays

JMP

Prism

Tangential Flow Filtration (TFF)

Job description

We are seeking a motivated and detail-oriented Scientist 3 to join our Formulation team. In this hands-on laboratory role, you will independently execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery. The successful candidate will be a collaborative team player with strong technical and data analysis skills who is ready to contribute to our non-viral delivery platform. The Opportunity: You will independently execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) encapsulating nucleic acids for in vitro and in vivo studies. You will lead DoE-based screening campaigns directed toward discovering LNPs, setting LNP composition specifications, and optimizing LNP formulations.. You will collaborate cross-functionally with internal teams (biology, analytics, chemistry, and project management) to advance programs. You will support early-stage formulation development and downstream processing activities, including cryoprotection, scale-up, and stability studies as needed. You will maintain detailed records documenting formulation activities and results. You will analyze, interpret, and present experimental data in group meetings. You will troubleshoot formulation challenges and continuously improve workflows. This is an onsite role based in San Diego, CA. Relocation benefits are not being offered for this position.

Who You Are

• (Required) You have a PhD in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with relevant academic and/or biopharma industry experience; OR a Master’s degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 3+ years of industry experience.
• You have 2 or more years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA) for in vitro and in vivo studies.
• You have a highly proficient with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• You have a demonstrated level of expertise in MS Excel; hands-on experience with statistical and data analysis software (e.g., JMP, Prism)
• You have a demonstrated level experience in the LNP field in the form of publications and/or patent filings.
• Preferred: You have experience with Tangential Flow Filtration (TFF) and bioconjugation chemistry is highly desirable.
• You have experience working in an FDA-regulated environment
• You have strong communication skills including the ability to communicate with all levels within the organization; you are hands-on, self-directed, organized, conscientious.
• You have strong problem-solving, judgment and decision-making skills
• You have strong time management and organizational skills in a dynamic, continually changing environment; you have the ability to respond effectively to sensitive inquiries, customer inquiries or complaints as well as communicate effectively both orally and in writing with management, peers and individuals.
• You have the ability to work effectively, exhibit a professional manner and establish constructive working relationships.
• You have excellent written and verbal communication skills

The expected salary range for this position based on the primary location of San Diego, CA is $89,900 - $166,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.