Scientist 2 - Immune Cloaking

Genentech; San Diego (CA); On-site; USD 74,000 - 138,000; Full time

Benefits offered by this job

Discretionary annual bonus

Job summary

Genentech seeks a Scientist 2 for its Immune Cloaking team in the Cell Therapy Technologies group in San Diego. The role focuses on engineering next-generation allogeneic CAR‑T cell therapies and testing immune cloaking strategies to resist rejection.

The position reports to a Principal Scientist and drives rigorous data generation, ELN compliance, and cross-functional collaboration to advance immune cloaking programs.

Qualifications

• Education: Bachelor’s or Master’s with 5+ years in a cell therapy setting.
• Cell therapy expertise including CAR‑T generation and characterization.
• Experience with T/NK/myeloid cell culture and non-viral gene delivery.
• Proficiency with multi-color flow cytometry and functional assays.
• Strong data recording and scientific communication skills.

Responsibilities

• Design, execute and interpret complex experiments to validate immune cloaking targets.
• Maintain ELN-compliant records ensuring data integrity.
• Present findings in group meetings and cross-functional teams.
• Mentor colleagues and foster a safe, collaborative lab environment.

Skills

Cell Culture

Gene delivery

Flow cytometry

Molecular biology

Scientific rigor

Soft skills

Motivation

Education

Bachelor’s/Master’s degree in cell therapy

Job description

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come.

Creating a world where we all have more time with the people we love. That’s what makes us Genentech!

The Opportunity

We are seeking a highly motivated and intellectually curious Scientist 2 to join the Immune Cloaking team within the Cell Therapy Technologies group. In this role, you will be a core member of a multidisciplinary team focused on engineering next-generation allogeneic cell therapies. You will work on the frontier of immuno-oncology, designing and testing strategies to render CAR-T cells resistant to immune rejection.

This is a lab-based role for a scientist who is energized by complex biological problems and is dedicated to translating mechanistic insights into clinical medicines. Reporting to a Principal Scientist, you will function as a core experimentalist, contributing to the development of robust immune cloaking strategies. You will have the opportunity to leverage world-class capabilities in cell engineering, gene editing, and functional screening to overcome barriers to allogeneic cell therapy efficacy.

You will work closely with cross-functional project teams to advance our immune cloaking programs, ensuring high-quality data generation and rigorous scientific interpretation.

Key Responsibilities

• Experimental Design & Execution: Independently design, execute, and interpret complex experiments to validate novel immune cloaking targets and mechanisms. Proactively brainstorm next steps and troubleshoot experimental bottlenecks.
• Data Analysis & Record Keeping: Maintain meticulous laboratory records, including timely adherence to Electronic Lab Notebook (ELN) standards, to ensure data integrity and traceability.
• Communication: Present research findings through high-quality internal presentations at group meetings and to cross-functional project teams.
• Team Collaboration: Foster a collaborative culture by sharing expertise, providing technical mentorship where appropriate, and contributing to a safe and efficient lab environment.

Who You Are

• Education: Bachelor’s/Master’s degree with 5+ years of industry experience in a cell therapy team generating and characterizing CAR‑T cells.
• Core Technical Skills:
  • Cell Culture: Extensive experience with isolation and culture of primary T, NK and myeloid cells.
  • Gene delivery and editing: Delivery of non-viral payloads to create genetically engineered cells.
  • Assay Proficiency: Hands‑on experience designing and executing multi‑color flow cytometry (10+ colors) and the development and execution of cell‑based killing and functional assays.
  • Molecular Biology: Proficiency in plasmid design and cloning. Ability to execute qPCR and RT-PCR assays.
  • Scientific Rigor: Ability to independently design, execute, and interpret controlled experiments. Prior experience writing IND‑enabling documents preferred.
• Soft Skills: Strong interpersonal skills with the ability to communicate scientific data effectively in cross‑functional forums.
• Motivation: A genuine enthusiasm for collaborative, team‑based science and the curiosity to explore unconventional ideas.

Relocation benefits are not available for this job posting.

The expected salary range for this position based on the primary location of San Diego, CA is $74,300 to $138,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.