Scientist 1, Bioanalytical

Nurix; Brisbane (CA); On-site; USD 142,000 - 176,000; Full time

Job summary

Nurix Therapeutics is seeking a Scientist 1 to join the Bioanalytical team in Brisbane, CA. You will develop and run LC-MS/MS assays for targeted protein degrader candidates, quantify drugs and metabolites, and report high-quality data to support in vivo and in vitro studies.

You will independently develop LC-MS/MS methods, troubleshoot equipment, and collaborate with pharmacology, chemistry and biology teams, contributing to drug discovery programs with rigorous data generation and

Qualifications

• BS or equivalent with 10+ years in discovery LC-MS/MS.
• MS with 6+ years in discovery LC-MS/MS.
• PhD with up to 4 years in discovery LC-MS/MS.

Responsibilities

• Provide bioanalytical support for in vivo PK, PK/PD, efficacy studies.
• Develop LC-MS/MS methods to quantify small molecules in samples.
• Operate and maintain LC-MS/MS equipment.
• Collaborate with pharmacology, chemistry and biology teams.
• Document and maintain lab notebooks.

Skills

LC-MS/MS experience

Sciex platforms

Bioanalytical method development

Team collaboration

Education

BS with 10+ years in discovery LC-MS/MS

MS with 6+ years in discovery LC-MS/MS

PhD with up to 4 years in discovery LC-MS/MS

Tools

LC-MS/MS instrumentation

Job description

Position Description

Help drive Nurix’s drug discovery programs by turning complex biological samples into the high-quality bioanalytical data that guides decisions. You will develop and run LC-MS/MS assays for targeted protein degrader candidates and work closely with pharmacology, chemistry and biology teams.

Nurix Therapeutics is searching for a motivated Scientist 1 to join our Bioanalytical team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. The primary responsibility will be to conduct quantitative bioanalysis for in vivo samples. The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrix (e.g. blood, plasma, tissues, tumor, CSF, etc.), and reporting high-quality data. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.

The Opportunity

• Provide bioanalytical support for in vivo PK, PK/PD, efficacy studies, non-GLP toxicology and in vitro studies
• Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis
• Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples and execute sample analysis
• Independently operate, troubleshoot and maintain LC-MS/MS and analytical equipment
• Participate in multidisciplinary project teams and partner closely with other departments, including pharmacology, chemistry and biology to understand bioanalytical needs for PK support
• Maintain accurate and detailed laboratory notebooks
• Ability to think and plan strategically, and excellent interpersonal skills and ability to work in a team environment

What You’ll Bring

• BS or equivalent with 10 or more years’ relevant experience, or MS with 6 or more years’ relevant experience, or PhD with up to 4 years’ relevant experience working in a discovery setting using quantitative LC-MS/MS within a pharmaceutical or biotechnology company
• Demonstrated experience in small molecule biomarkers as well as drug candidate bioanalytical assay development/sample quantitative analysis in complex biological matrices using LC-MS/MS
• Proven experience running and troubleshooting LC-MS/MS-based quantitative workflows on Sciex platforms and software
• Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment
• Ability to work in a fast-paced, collaborative environment and manage multiple priorities

Preferred Qualifications

• Experience in targeted protein degradation or heterobifunctional degrader platforms
• Extensive experience with H/UPLC and mass spectrometry
• Extensive experience with sample analysis to support PK, PK/PD, efficacy, distribution, metabolism, and non-GLP toxicology studies
• Extensive experience in developing and implementing quantitative LC-MS/MS based assays for small molecules in complex biological matrices
• Excellent oral and written communication skills
• Experience reviewing result files and reports from bioanalytical contract research organizations
• Experience with maintaining detailed up to date lab notebooks and technical documentation

Location:

Onsite – Brisbane, CA

Salary Range:

$141,500 - $175,600

The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.

Fit with Nurix Culture and Values

• Strong team orientation; highly collaborative
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

About Nurix Therapeutics

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the frontier of patient care, writing medicine’s next chapter with a new script to outmatch disease.