Scientist

Isac Net; Pennsylvania; On-site; USD 130,000 - 180,000; Full time

Job summary

Johnson & Johnson in Spring House, PA seeks a Senior Scientist, Cell Therapy Genetic Regulation to advance gene modulation strategies for CAR T cell therapy programs. You will work with human T cells to design, optimize, and deploy regulation tools and screening workflows to support discovery and development.

The role emphasizes independent lab work, collaboration across teams, and staying at the forefront of genetic regulation and cell therapy innovations to deliver next‑generation therapies

Qualifications

• PhD in Molecular Biology, Bioengineering, Genetics or a related biological research discipline.
• Minimum 2 years of post‑PhD experience (biopharmaceutical or biotech experience preferred).
• Strong knowledge in genetic regulation strategies and genetic modulation technologies.
• Demonstrated experience designing, screening, and validating genetic regulation tools in a cell therapy‑relevant context.
• Ability to independently perform lab‑based responsibilities with limited guidance.
• Strong collaborative skills and experience coordinating experiments and data exchange across teams.

Responsibilities

• Lead development of genetic regulation tools tailored for multiple cell therapy platforms.
• Design, execute, and optimize screening workflows to identify and validate gene modulation designs.
• Advance assay development and validation pipelines to ensure on‑target activity, specificity, and functional effects in relevant cell therapy platforms.
• Collaborate with cross-functional teams to drive project milestones and align experimental plans with program timelines.
• Stay current on genetic regulation and cell therapy advancements and propose new research directions.
• Communicate results to senior leadership and partners in clear technical reports.

Skills

Genetic regulation

Cell therapy context

Independent lab work

Collaborative skills

Lab data interpretation

Education

PhD in Molecular Biology, Bioengineering, Genetics

Minimum 2 years post-PhD experience

Job description

Employer

Johnson & Johnson

Title

Senior Scientist, Cell Therapy Genetic Regulation

Location

Spring House, Pennsylvania, United States of America

Job Function

Discovery & Pre-Clinical/Clinical Development

Job Sub Function

Biotherapeutics R&D

Job Category

Scientific/Technology

Job Description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com .

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

We are searching for the best talent for a Senior Scientist, Cell Therapy Genetic Regulation to be located in Spring House, PA.

Purpose

We are seeking a motivated and high performing Senior Scientist to join the Cell and Genetic Medicines group within Therapeutics Discovery (TD) to support the development of CAR T cell therapy programs. In this role, you will be applying cutting‑edge genetic regulation approaches to develop and implement gene modulation strategies that enhance the safety, efficacy, persistence, and functionality of CAR T cell therapy platforms. You will work directly with human T cells - including culture, activation, expansion, and genetic modification - to design, optimize, and deploy genetic regulation tools and screening workflows that support the discovery and advancement of next‑generation cell therapy programs. The ideal candidate will combine deep technical expertise in genetic engineering with the ability to work independently in the lab and collaborate across cross‑functional teams. This role is an exciting opportunity to join a diverse and ambitious discovery team and to work with innovative technology to create life‑changing therapies for patients.

You will be responsible for:

• Lead development of genetic regulation tools tailored for multiple cell therapy platforms.
• Design, execute, and optimize screening workflows to identify and validate gene modulation designs.
• Advance assay development and validation pipelines to ensure on‑target activity, specificity, and functional effects in relevant cell therapy platforms.
• Collaborate closely with other team members and cross‑functional teams to drive project milestones, produce shared data packages, and align experimental plans with program timelines.
• Stay current on the latest scientific and technological advancements in genetic regulation and cell therapy, incorporate new knowledge into ongoing projects and propose new research directions.
• Analyze experimental data, prepare clear technical reports, and effectively communicate results to senior leadership, internal partners, and external partners as required.
• Maintain accurate and detailed experimental procedures, data, and results in an electronic laboratory notebook and ensure compliance with laboratory protocols and safety procedures.

Qualifications

Required

• PhD in Molecular Biology, Bioengineering, Genetics or a related biological research discipline.
• Minimum 2 years of post‑PhD experience (biopharmaceutical or biotech experience preferred).

• Strong knowledge in genetic regulation strategies and genetic modulation technologies.
• Demonstrated experience designing, screening, and validating genetic regulation tools in a cell therapy‑relevant context.
• Ability to independently perform lab‑based responsibilities with limited guidance.
• Strong collaborative skills and experience coordinating experiments and data exchange across teams.
• Self‑motivated, highly organized, and able to manage competing priorities in a fast‑paced discovery environment.

Preferred

• Hands‑on experience in molecular cloning, including the design, construction, and screening of pooled libraries for high‑throughput assays.
• Experience with primary human T cell culture, expansion, and genetic engineering (viral transduction and/or non‑viral gene editing).
• Experience in lentiviral vector design and optimization experience is preferred.
• Familiarity with flow cytometry, next‑generation sequencing, and basic bioinformatics analyses.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center ([e-mail]) or contact AskGS to be directed to your accommodation resource.

Required Skills

Analytical Reasoning, Biochemistry, Chemistry, Manufacturing, and Control (CMC), Coaching, Consulting, Critical Thinking, Drug Discovery Development, Emerging Technologies, Molecular Diagnostics, Pharmacogenetics, Pharmacovigilance, Process Improvements, Quality Assurance (QA), Relationship Building, Research Documents, Scientific Research, Technologically Savvy