RNA Therapeutics Scientist: Patient-Derived Models

St. Jude Children's Research Hospital, Inc.; Memphis (TN); On-site; USD 86,000 - 155,000; Full time

Job summary

St. Jude Children's Research Hospital, Inc. seeks a rigorous Scientist for the PDD Core within the Pediatric Translational Neuroscience Initiative.

The role focuses on patient-derived cell model development, high-throughput screening, and RNA biology to advance antisense therapies for ultra-rare conditions. The ideal candidate has plate-based screening experience, RNA biology expertise, and the ability to drive multi-step workflows across parallel projects with rigor and collaboration in a

Qualifications

• Bachelor's degree in a relevant scientific field is required.
• Experience with plate-based screening workflows and RT-qPCR/ddPCR is preferred.
• Strong background in RNA biology and pre-mRNA splicing is desirable.
• Ability to manage multi-step workflows across parallel projects with rigor.

Responsibilities

• Design and execute cell-based therapeutic evaluation workflows with high rigor across concurrent patient cases.
• Derive, characterize, and bank patient-specific cellular models for screening and validation.
• Design and validate quantitative molecular assays (RT-qPCR, ddPCR) and perform readouts to evaluate efficacy.
• Manage parallel timelines and maintain proactive communication with collaborators.
• Maintain documentation, data integrity, and quality control in a Core lab setting.
• Support equipment calibration, maintenance, and stock monitoring.

Skills

Plate-based screening

RNA biology

Mammalian cell culture

Quantitative assays

Parallel project management

Education

Bachelor's degree

Master's degree

PhD

Tools

Janus liquid handlers

Job description

St. Jude Children's Research Hospital, Inc. seeks a rigorous Scientist for the PDD Core within the Pediatric Translational Neuroscience Initiative.

The role focuses on patient-derived cell model development, high-throughput screening, and RNA biology to advance antisense therapies for ultra-rare conditions. The ideal candidate has plate-based screening experience, RNA biology expertise, and the ability to drive multi-step workflows across parallel projects with rigor and collaboration in a