Research Technician I/II- Preall Lab

Cold Spring Harbor Laboratory; Cold Spring Harbor (NY); On-site; USD 45,000 - 50,000; Full time

Job summary

An esteemed biomedical research institution is seeking a motivated Research Technician to join its innovative team. This role involves developing and implementing cutting-edge spatial ‘omics approaches, collaborating with scientists on diverse projects in cancer biology, neuroscience, and plant genomics. The ideal candidate will have hands-on experience in molecular biology and imaging, contributing to significant advancements in research. Join a dynamic environment that fosters creativity and collaboration, where your contributions will impact the future of science and healthcare. If you are passionate about research and eager to tackle challenging protocols, this opportunity is perfect for you.

Benefits

Competitive Pay

Exceptional Health Benefits

Retirement Plans

Time Off

Recognition Programs

Wellness Programs

Qualifications

• Bachelor’s degree required; 2+ years of lab experience preferred.
• Strong background in molecular biology and imaging techniques.

Responsibilities

• Develop and optimize protocols for spatial gene expression analysis.
• Collaborate on projects with defined timelines and deliverables.

Skills

Molecular Biology

Histology

RNA Handling

DNA Handling

Protein Analysis

Project Management

Critical Thinking

Problem-Solving

Collaboration

Communication

Education

Bachelor's Degree

Tools

10x Genomics Xenium

10x Genomics Visium

Lunaphore COMET

Job description

Job Title: Research Technician I/II- Preall Lab

Job Number: 95087

Location: Cold Spring Harbor, US

Job Description

Position Description

The Single Cell Biology core facility at Cold Spring Harbor Laboratory (CSHL) is currently seeking a motivated research technician to develop and implement spatial ‘omics approaches. The core collaborates with scientists at CSHL and other regional institutions to design, execute, and interpret spatial transcriptomics and molecular imaging experiments, as well as develop custom imaging and in situ sequencing technologies for projects with specialized needs. The ideal candidate will have the opportunity to contribute to innovative projects across diverse scientific disciplines, including cancer biology, neuroscience, and plant genomics. College students graduating by summer 2025 are highly encouraged to apply.

Position Responsibilities

Responsibilities will include:

1. Developing and optimizing protocols for the 10x Genomics Xenium and Visium spatial gene expression analysis platforms.
2. Implementing and refining multiplexed immunofluorescence (mIF) protein imaging workflows on the Lunaphore COMET system.
3. Preparing and processing tissue samples for spatial RNA and protein profiling, including fixation, sectioning, and staining.
4. Collaborating with institutional scientists on projects with well-defined timelines and deliverables, demonstrating strong project management skills by working on experiments from inception to completion.
5. Maintaining laboratory organization, instrumentation, and reagent inventories.
6. Participating in the design, analysis, and presentation of experiments, applying critical thinking and problem-solving skills to troubleshoot technical challenges and interpret results.

Position Requirements

Bachelor’s degree required; 2+ years of experience in a laboratory setting preferred. Strong background in molecular biology, histology, or imaging, with experience handling and analyzing RNA, DNA, and proteins. Hands-on experience with tissue processing, microscopy, and fluorescence-based detection techniques preferred. Proven ability to work on projects from their initial planning stages through execution and analysis, demonstrating initiative, independence, and attention to detail. Candidate must be independent, creative, persistent, and thorough, with an enthusiasm for developing new and challenging protocols and techniques. Excellent collaboration and communication skills are essential. Special consideration for applicants with familiarity of advanced concepts, including image analysis, computational biology, high-content imaging, or microfluidics.

Environment

Cold Spring Harbor Laboratory is a world-renowned biomedical research institution in New York. It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates. Cold Spring Harbor Laboratory provides a highly dynamic and interactive research environment and also a unique opportunity of timely exposure to advances in various biomedical research fields and of interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program. We believe that science is for everyone and our researchers have a wide variety of backgrounds.

Compensation and Benefits

Our employees are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our CSHL [Please click the Apply button for the link or email] sites to learn more. The salary range for this role is $45,000.00-49,449. The salary range and/or hourly rate listed is a good faith determination of potential base compensation that may be offered to a successful applicant for this position at the time of this job advertisement and may be modified in the future. When determining a base salary and/or rate, several factors may be considered as applicable (e.g., years of relevant experience, education, credentials, and internal equity).

Application Deadline: 2025-10-01