Research Scientist, Inflammatory Bowel Disease (IBD) Drug Discovery

USA - 3316 Takeda Development Center Americas, Inc.; Cambridge (MA); On-site; USD 116,000 - 182,000; Full time

Job summary

Takeda's Gastrointestinal and Inflammation (GI2) Drug Discovery Unit in Cambridge, MA is assembling a team of experienced researchers to deliver an industry-leading portfolio of drugs for GI, autoimmune, and inflammatory diseases.

You will provide technical leadership for project implementation from conception through candidate selection, generate rigorous data, and contribute scientific insight within a collaborative team.

Qualifications

• PhD in a scientific discipline (or MS with 6+ years relevant experience)
• Demonstrated accomplishments in inflammation and/or immunology research; IBD experience is a plus
• Strong expertise in molecular biology, cell biology, and immunology; experience with cell-based and biochemical assays
• Hands-on experience with flow cytometry, primary human immune cells and fibroblasts, cytokine analysis, qPCR, and gene editing (CRISPR/siRNA)
• Experience developing in vitro assays to characterize potency and mechanism of action
• Experience in in vivo efficacy, pharmacology, and MoA studies in rodent models
• Ability to design experiments independently and collaborate in a matrixed team
• Excellent written and verbal communication; strong organizational skills

Responsibilities

• Identify, plan, and execute well-defined scientific projects
• Initiate investigation of new experimental approaches to problems using scientific theory and literature
• Use defined practices to analyze results and determine actions
• Contribute to solving complex problems and achieving team objectives
• Prepare and present comprehensive project and technical reports to internal and external audiences

Skills

Molecular biology

Cell biology

Immunology

Flow cytometry

Cytokine analysis

qPCR

CRISPR / gene editing

In vivo pharmacology

Data analysis

Project coordination

Education

PhD in a scientific discipline

MS with 6+ years relevant experience

BS with 8+ years relevant experience

Tools

ELISA

MSD / AlphaLISA

CRISPR gene editing

qPCR equipment

Job description

Job Description Objective / Purpose:

The Gastrointestinal and Inflammation (GI2) Drug Discovery Unit at Takeda is building a new team of experienced, innovative, and collaborative researchers to deliver an industry-leading portfolio of drugs for various gastrointestinal, autoimmune, and inflammatory diseases with high unmet medical needs. We seek a Research Scientist to join our biology and cross-functional discovery teams and create novel drug candidates.

Your role:

provides technical leadership for research project implementation and coordination, begins at the conception of new projects and helps advance to candidate selection, generates exciting and rigorous data that drive confident decisions, contributes critical thinking, technical expertise, and scientific insight to teamwork, and maintains our Takeda culture that promotes creativity, open communication, cooperation, and urgency while delivering the highest quality of science for drug discovery.

Accountabilities:

• Identify, plan, and execute well-defined scientific projects
• Initiate investigation of new experimental approaches to specific problems using scientific theory and technical literature
• Use defined practices and theoretical knowledge to perform analyses, interpret results, and determine appropriate actions
• Utilize relevant information, technology, and resources to proactively contribute to solving complex problems and achieving objectives as a team
• Prepare and present comprehensive project and technical reports to a range of internal and external audiences

Education & Competencies (Technical and Behavioral):

• PhD degree in a scientific discipline (or equivalent), or MS with 6+ years relevant experience, or BS with 8+ years relevant experience
• Demonstrated accomplishments in inflammation and/or immunology research, with a track record of applying scientific insight to address complex biological questions; experience in inflammatory bowel disease is a plus
• Strong expertise in molecular biology, cell biology, and immunology, with experience developing cell-based and biochemical assays
• Hands-on experience with key technologies including flow cytometry, primary human immune cell and fibroblast culture, cytokine analysis (AlphaLISA, MSD, ELISA), qPCR, and gene editing approaches (e.g., CRISPR, siRNA)
• Experience developing in vitro assays to characterize small and large molecules for potency and mechanism of action
• Experience contributing to the design and execution of in vivo efficacy, pharmacology, and MoA studies in rodent models
• Ability to independently design and execute experiments while contributing effectively within a collaborative, matrixed team environment
• Strong problem-solving skills with the ability to generate high-quality data and derive insights that inform project decisions
• Excellent written and verbal communication skills and the ability to work effectively in a highly matrixed environment
• Strong organizational and multi-tasking skills with attention to detail

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location: USA - MA - Cambridge - Binney St U.S. Base Salary Range: $116,000.00 - $182,270.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations USA - MA - Cambridge - Binney St

Worker Type Employee Worker Sub-Type Regular Time Type Full time Job Exempt Yes

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Takeda is an industry-leading, global pharmaceutical company with an unwavering dedication to putting patients at the center of everything we do. We live our values of Takeda-ism - Integrity, Fairness, Honesty, and Perseverance - and are united by our mission to strive towards Better Health and a Brighter Future for people worldwide through leading innovation in medicine.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission.

At Takeda, you will make an impact on people’s lives – including your own.

Takeda is an equal opportunity employer.