Research Scientist

BioSpace; Durham (NC); On-site; USD 124,000 - 186,000; Full time

Benefits offered by this job

Medical insurance

401k retirement plan

Paid vacation (flexible)

Job summary

Jazz Pharmaceuticals is seeking a full-time, laboratory-based scientist to design and execute experiments on anticancer compounds with emphasis on receptor tyrosine kinases, preferably HER2. The role includes documenting protocols and data, and communicating findings through publications, abstracts, and talks.

The candidate will manage cancer cell culture, develop RTK/HER2 signaling models, and create stable cell lines using CRISPR.

Qualifications

• Three or more years of industry or post-doctoral experience in oncology.
• Demonstrated expertise in receptor tyrosine kinase biology, preferably including HER2.
• Excellent written and verbal communication including publications and conference presentations.

Responsibilities

• Design and execute experiments to study anticancer compounds focusing on RTK/HER2-driven models.
• Create stable cell lines with CRISPR and inducible expression.
• Present results for internal and external communications; prepare manuscripts and conference abstracts.

Skills

RTK/HER2 biology

Oncology assays

Publications & presentations

Independent work

Education

PhD in cancer biology or related field

Tools

CRISPR

Job description

Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families.

We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options.

We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments.

Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience.

Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide.

Please visit www.jazzpharmaceuticals.com for more information.

Brief Description

Responsible for designing and executing experiments relating to the efficacy and mechanism of action of anticancer compounds with little supervision, with a specific focus on receptor tyrosine kinases (RTKs), preferably HER2. Responsible for documenting and archiving experimental protocols, data, analyses, and conclusions according to established laboratory procedures. Expected to participate in communication of research into publications, conference presentations, abstracts, and patent applications. Self-motivated and works under general supervision on multiple projects. This position is a full time laboratory-based position.

Essential Functions/Responsibilities

• Manage cell culture of cancer and normal cell lines.
• Perform in vitro efficacy, mechanism of action, target validation, and biomarker studies with cancer therapeutics, with an emphasis on RTK/HER2-driven models.
• Create stable cell lines with CRISPR and inducible expression, including lines engineered to modulate RTK/HER2 signaling.
• Create or adapt reporter systems for relevant molecular targets
• Present summary results for internal communications and external presentations.
• Support preparation of conference abstracts and manuscripts for publication as needed.
• Develop proper operational, data documentation, and troubleshooting procedures.
• Such other responsibilities and projects that the Company may assign.

Required Knowledge, Skills, And Abilities

• Requires the ability to perform routine laboratory work, sit or stand at a computer for long stretches of time and type. Frequently operates a computer and other office productivity machinery, such as a calculator, copy machine, and computer printer. The person in this position needs to occasionally move about inside the office to access file cabinets and office equipment. May occasionally lift objects up to 25 pounds.
• Three or more years of industry or post-doctoral experience in oncology.
• Demonstrated expertise in receptor tyrosine kinase biology, preferably including HER2, with experience characterizing RTK signaling, pathway modulation, and therapeutic mechanisms of action.
• Experience in oncology and pharmacology assays and techniques.
• Exceptional written and verbal communication including publications and conference presentations.
• Team player who is highly organized and able to manage multiple concurrent projects with minimal oversight.
• Forward-thinking with the ability to anticipate challenges and proactively implement solutions.
• Computer proficient.
• Experience driving advancement of numerous projects simultaneously.
• Ability to identify and initiate tasks, set goals for completion, create timelines, and monitor progress to ensure completion.
• Strong sense of urgency to meet business needs.
• A positive, "hands-on" approach to the position.
• Demonstrated ability to react and respond professionally to changing priorities and timelines.
• Demonstrated success in working in a matrix, cross-functional environment.
• Demonstrated ability to communicate clearly both written and oral and work independently with a high level of attention to detail.

Required/Preferred Education And Licenses

• Ph.D. in cancer biology, molecular/cell biology, biochemistry, pharmacology, or related fields, or master’s degree with relevant experience.

Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law.

FOR US BASED CANDIDATES ONLY

Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is: $124,000.00 - $186,000.00

Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis.

At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan.

The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here: https://careers.jazzpharma.com/benefits.html.