Research Postdoctoral Fellow-Tong Lab

Children's Hospital of Philadelphia; Philadelphia (Philadelphia County); On-site; USD 20,800 - 110,400; Full time

Job summary

Children’s Hospital of Philadelphia (CHOP) invites applications for a postdoctoral fellow to lead state-of-the-art CRISPR/Cas9 screens aimed at identifying new therapeutic targets for hematopoietic stem cell diseases. Under a mentor, you will conduct independent research, refine methods, and contribute to the lab's goals.

You will gain skills in project planning, data analysis, manuscript and grant writing, and supervision of junior lab members, with opportunities to present findings at national

Qualifications

• Doctorate required.
• Ability to wear a respirator device.

Responsibilities

• Conduct independent scholarly research and develop new methods and protocols.
• Participate in project planning, record, and evaluate data.
• Acquire technical, lab‑management, and grant‑writing skills.
• Participate in seminars, lectures, poster sessions, and present at national meetings.
• Supervise junior lab members.
• Assist with other research projects.

Skills

Ability to wear a respirator device

Education

Doctorate Required

Job description

Seeking Breakthrough Makers

Children’s Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

Location

United States of America

A Brief Overview

Under the direction and guidance of a mentor (principal investigator), this postdoctoral fellow will assume responsibility for an ongoing research project. The experience will serve to extend, refine, and enhance skills necessary for professional and career development, enabling the individual to broaden their scientific background by acquiring new research capabilities. The incumbent is expected to conduct independent scholarly research, contribute directly to the overall research goals of the project and the research group, participate in project planning, record and interpret data, communicate results, acquire technical, lab‑management, and manuscript‑/grant‑writing skills, supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

CRISPR screens in hematopoietic stem cells to study DNA repair and DNA replication

A postdoctoral fellow position is available at the University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia to perform state‑of‑the‑art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases. Dr. Tong’s laboratory studies cytokine receptor signaling in replication stress, DNA repair, and ubiquitin signaling in hematopoietic stem cells, bone marrow failure, and leukemia. The focus is on mechanisms that safeguard the genome during DNA replication and how failures in these processes impact hematopoietic stem cell function, leading to bone marrow failure and/or leukemia. CRISPR screens with expert collaborators will delineate new understanding of stem cell fitness under replication stress and identify potentially druggable pathways for intervention.

• Cell Stem Cell, 28(7):1275-1290, 2021


• Journal of Clinical Investigation, 136(1):e191713, 2026


• Blood, 138(22):2244-2255, 2021


• Blood, 133(14):1560-1571, Apr 2019


• Nature Communications, 9(1):3915, Sep 2018


• Genes & Development, 31(10):1007-1023, May 2017

You can find additional recent publications and laboratory information on the department website: https://www.med.upenn.edu/apps/faculty/index.php/g275/p8146029

What You Will Do

• Conduct independent scholarly research and develop new methods and protocols


• Participate in project planning, record, and evaluate data


• Acquire technical, lab‑management, and grant‑writing skills


• Participate in seminars, lectures, poster sessions, and present at national meetings


• Supervise junior lab members


• Assist with other research projects

Education Qualifications

• Doctorate Required

Skills And Abilities

• Ability to wear a respirator device

Salary Range

$20,800.00 – $110,400.00 Annually. Salary ranges are shown for full‑time jobs. For part‑time employees, compensation will be adjusted accordingly. Research Post‑doctoral Fellows should refer to the mandatory salary guidelines at https://www.research.chop.edu/services/hiring-a-postdoctoral-fellow#collapse-accordion-3523-3. At CHOP, compensation is fair and transparent; skills and experience may result in an offer above the stated range. See CHOP’s Compensation and Benefits for details.

EEO Statement

CHOP is an equal‑employment‑opportunity employer committed to diversity and inclusion. CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any legally protected category. Mandatory influenza vaccination is required for employees working in patient‑care buildings or with patient‑facing responsibilities.