Research Opportunities - McDonnell Genome Institute

Washington University in St. Louis; St. Louis (MO); On-site; USD 70,000 - 100,000; Full time

Job summary

Washington University in St. Louis seeks a highly motivated scientist to join the Functional Genomics team at the Goldfarb Center for Neuronal Resiliency. The project aims to identify targets and therapies for ALS and Parkinson’s disease using iPSC-derived neuronal models.

The role includes conducting CRISPR screens, integrating perturbations with phenotypic assays and sequencing, and collaborating across disciplines to drive translational neuroscience research.

Qualifications

• Bachelor’s degree or combination of education and/or experience may substitute for minimum education.

Responsibilities

• Conduct CRISPR screens in human iPSC-derived neuronal models.
• Integrate CRISPR perturbations with phenotypic assays and molecular readouts (flow cytometry, sequencing).
• Collaborate within the functional genomics team to advance neurodegenerative disease research.

Education

Bachelor’s degree

Job description

Position Summary

We are seeking a highly motivated scientist to join our functional genomics team at the Goldfarb Center for Neuronal Resiliency at the McDonnell Genome Institute, WashU Medicine. The Goldfarb Center for Neuronal Resiliency was established to identify new therapeutic targets and treatments for neurodegenerative diseases, particularly ALS and Parkinson’s disease.

Central to this effort are CRISPR screens that identify genes that make neurons more vulnerable or resilient to stress. These screens will use human induced pluripotent stem cell (iPSC)-derived neuronal models of neurodegenerative diseases. Work in the lab also integrates CRISPR perturbations with phenotypic assays and molecular readouts using flow cytometry, high content imaging, next-generation sequencing, and single-cell, spatial, and in situ profiling.

Location

ST. LOUIS, MO 63108

Scheduled Hours

40

Job Description

For more about this project, visit https://genome.wustl.edu/the-resiliency-project-advancing-neurodegenerative-disease-research-at-mgi/.

Working Conditions

• Because some cell culture, differentiation, and time-sensitive experimental workflows require procedures on specific days, the successful candidate must be able to accommodate occasional weekend work when required by experimental schedules.
• This position works in a laboratory environment with potential exposure to biological and chemical hazards.
• The individual must be physically able to wear protective equipment.

Salary Range

Base pay is commensurate with experience.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Education

Required Qualifications
Bachelor’s degree or combination of education and/or experience may substitute for minimum education.

Certifications/Professional Licenses

No specific certification/professional license is required for this position.

Work Experience

No specific work experience is required for this position.

Skills

Not Applicable

Driver's License

A driver's license is not required for this position.

Preferred Qualifications

• Candidates with a bachelor's, master's degree, or PhD will be considered.
• Substantial research experience in molecular biology, cell biology, genetics, genomics, neuroscience, bioengineering, or a related field.
• Strong hands-on experience in mammalian cell culture and molecular biology.
• Strong organizational skills and ability to manage multiple experiments and priorities.
• Strong written and verbal communication skills.

Preferred Experience

Experience in one or more of the following areas would be highly desirable:

• CRISPR/Cas genome editing, CRISPR screening, or functional genomics.
• Human iPSC culture and differentiation, particularly neuronal differentiation.
• Lentiviral vector production and transduction.
• Flow cytometry and fluorescence-activated cell sorting (FACS).
• Reporter assay development and engineered stable cell lines.
• qRT-PCR and Western blotting.
• DNA/RNA purification, PCR, cloning, and other molecular biology techniques.
• Next-generation sequencing and sequencing-library preparation.

Experience with every technique listed above is not required. Candidates with a strong foundation in mammalian cell and molecular biology, demonstrated scientific independence, and the ability to rapidly learn new technologies are encouraged to apply.

Final appointment and title will be commensurate with the candidate's qualifications and experience.

Grade

00

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email [e-mail] or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Personal

• Up to 22 days of vacation, 10 recognized holidays, and sick time.
• Competitive health insurance packages with priority appointments and lower copays/coinsurance.
• Take advantage of our free Metro transit U-Pass for eligible employees.
• WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.

Wellness

• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!

Family

• We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? We’ve got you covered.
• WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.

For policies, detailed benefits, and eligibility, please visit: https://hr.wustl.edu/benefits/

EEO Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity or shared ancestry, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. As a federal contractor, the university maintains affirmative action programs to implement its equal employment opportunity policy for individuals with disabilities and protected veterans, in accordance with Section 503 of the Rehabilitation Act of 1973, as amended, and the Vietnam Era Veterans’ Readjustment Assistance Act of 1974 (VEVRAA), as amended.