Research Opportunities - Cardiology

Washington University in St. Louis; United States; Presencial; USD 40.000 - 64.000; Jornada completa

Descripción de la vacante

Washington University in St. Louis seeks a research professional for the Sah laboratory to study TRP/LRRC8a ion channel regulation and signal transduction in cardiac and skeletal muscle, adipose tissue, endothelium, and pancreatic islets.

The role involves electrophysiology, imaging, genetic mouse models, and biochemistry with cryo-EM and molecular docking to guide ion channel modulators. The successful candidate will work in a multidisciplinary setting, perform standard lab duties, maintain

Formación

• Bachelor’s degree or combination of education and/or experience may substitute for minimum education.
• No specific certification/professional license is required for this position.
• No specific work experience is required for this position.
• Not Applicable
• A driver's license is not required for this position.

Conocimientos

Cell biology

Protein biochemistry

Electrophysiology interest

Ion channel biology

Educación

Bachelor’s degree

Herramientas

Excel

Photoshop

Prism

Descripción del empleo

Location: SAINT LOUIS, MO 63110

Scheduled Hours: 40

Position Summary

The Sah laboratory at WashU Medicine in St. Louis (Department of Internal Medicine, Cardiology) and the Center for the Investigation of Membrane Excitability Disease (CIMED) studies the mechanisms of Transient Receptor Protein (TRP) and LRRC8a/ SWELL1 ion channel regulation and signal transduction. The laboratory uses electrophysiological (e.g., patch-clamp), imaging techniques, genetic mouse models (including CRISPR/cas9 technology), biochemical, and molecular approaches to investigate the regulation of signal transduction mechanisms of novel ion channels, including TRP/LRRC8 channels, in cardiac muscle, skeletal muscle, adipose tissue, and endothelium and pancreatic islet cells. Broadly speaking, the overarching goal of the Sah laboratory is to understand how ion channels and mechano-signaling influence cellular and organismal metabolism. We also combine medicinal chemistry with cryo-EM structure, molecular docking, and functional studies to guide synthesis of novel ion channel modulators for the treatment of human disease.

Job Description

Primary Duties & Responsibilities: Working Conditions: A laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment, provide standard care to research animals, and handle human biosamples.

Salary Range

Base pay is commensurate with experience.

Required Qualifications

• Bachelor’s degree or combination of education and/or experience may substitute for minimum education.
• No specific certification/professional license is required for this position.
• No specific work experience is required for this position.
• Not Applicable
• A driver's license is not required for this position.

Preferred Qualifications

• Strong background in cell biology and protein biochemistry with an interest in electrophysiology and ion channel biology.
• Working knowledge of computer software (Excel, Photoshop, and Prism) and general lab equipment.
• Demonstrated ability to work independently and communicate effectively.
• Troubleshooting skills.
• Ability to maintain complete and organized records.
• Effective verbal, written and interpersonal communication skills.
• Education: No additional education unless stated elsewhere in the job posting.
• Certifications/Professional Licenses: No additional certification/professional licenses unless stated elsewhere in the job posting.
• Work Experience: No additional work experience unless stated elsewhere in the job posting.
• Skills: Communication, Laboratory Research, Organizing, Recordkeeping, Working Independently.

Benefits Statement

Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.

Accommodations

If you are unable to use our online application system and would like an accommodation, please email [e-mail] or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Questions

Grade 00 Questions For frequently asked questions about the application process, please refer to our External Applicant FAQ.

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