Research Fellow-Neuroscience-Fiesel lab

Mayo Clinic; Jacksonville (FL); On-site; USD 67,000 - 79,000; Full time

Job summary

Mayo Clinic in Jacksonville, Florida, seeks a postdoctoral researcher to investigate pathogenic mechanisms of neurodegeneration in the laboratory of Dr. Fabienne Fiesel.

The work focuses on tau biology and protein homeostasis, with emphasis on UFMylation, using iPSC-derived models, mouse work, imaging and proteomics to illuminate disease biology and identify potential therapies.

Qualifications

• PhD or MD/PhD in neuroscience, cell biology, or biochemistry.
• Experience with iPSC models, mouse work, imaging or proteomics desirable.
• Track record of impactful, peer‑reviewed publications in relevant fields.
• Excellent verbal and written communication skills in English are essential.

Responsibilities

• Investigate mechanisms of neurodegeneration and tau biology in Mayo Clinic lab.
• Apply iPSC-derived systems, mouse models and proteomic approaches to study disease biology.
• Characterize pathways regulating tau and protein homeostasis.
• Explore genetic and pharmacological modulation of UFMylation as potential therapeutic strategies.

Skills

Verbal and written communication

English proficiency

Education

PhD or MD/PhD

Tools

iPSC models

Mouse work

Imaging

Proteomics

Job description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans– to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

• Medical:Multiple plan options.


• Dental:Delta Dental or reimbursement account for flexible coverage.


• Vision:Affordable plan with national network.


• Pre-Tax Savings:HSA and FSAs for eligible expenses.


• Retirement: Competitive retirement package to secure your future.

Responsibilities

Postdoctoral research positions are available in the laboratory of Dr. Fabienne Fiesel to investigate pathogenic mechanisms of neurodegeneration at Mayo Clinic in Jacksonville, Florida.

The Fiesel lab studies molecular pathways that regulate tau biology and protein homeostasis, with a particular interest in UFMylation and how alterations therein contribute to Alzheimer’s disease and related neurodegenerative disorders. The lab employs a multi-disciplinary approach using state-of-the-art techniques in cell biology, biochemistry, imaging, and proteomics to illuminate the underlying disease biology in iPSC-derived cell models, in vivo in mice, and in human clinical and neuropathological specimens.

Specific research projects include

• 1) investigation of mechanisms regulating tau aggregation and propagation in Alzheimer’s disease and related tauopathies,


• 2) identification of UFM1-modified proteins and pathways using biochemical and proteomic approaches,


• 3) mechanistic studies of tau and UFMylation in iPSC-derived cells and mouse models, as well as


• 4) genetic and pharmacological modulation of UFMylation as a potential therapeutic strategy.

For an overview of research and laboratory visit: https://www.mayo.edu/research/labs/cellular-mechanisms-neurodegenerative-disorders/overview

Mayo Clinic and the Department of Neuroscience offer an outstanding research and training environment with a competitive stipend and a generous fringe benefit package.

Qualifications

Applications are invited from highly motivated candidates holding a recent Ph.D. or M.D./Ph.D. with a strong research background in neuroscience, cell biology, or biochemistry. Expertise in iPSC models, mouse work, imaging or proteomics approaches is desirable. In addition, qualified candidates should have a record of impactful, peer-reviewed publications. Excellent verbal and written communication skills in English are essential

Exemption Status

Exempt

Compensation Detail

$67,282 - $78,711/ year; Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

Varies

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the'EOE is the Law'. Mayo Clinic participates inE-Verifyand may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.