Research Biologist

Axle; Bethesda (MD); On-site; USD 120,000 - 130,000; Full time

Benefits offered by this job

Paid Time Off (Including Holidays)

Employee Referral Bonus

401K Match

Tuition reimbursement and professional

Healthcare FSA

Parking Reimbursement Account

Dependent Care Assistant Program

Transportation Reimbursement Account

Job summary

Axle is seeking a Research Biologist to lead immunologic lung injury studies using next-generation sequencing, cell-free DNA/RNA analysis, and high-density proteomics to aid early diagnosis and monitor disease progression. The role targets patients at risk after stem cell transplantation, with emphasis on identifying molecular markers for tailored therapies.

Requires a Master's in Biology or Immunology and ≥5 years of experience, with strong experimental design, statistics, and

Qualifications

• Master's degree in Biology, Immunology, or a relevant field.
• At least five years of relevant scientific experience.
• Ability to design experiments and analyze results with appropriate statistical analysis.
• Ability to write methods and results sections for high‑quality scientific publications.
• Experience with next‑generation sequencing, cell‑free DNA/RNA analysis, and high‑density proteomics platforms.

Responsibilities

• Lead research on immunologic lung injury using advanced molecular techniques.
• Support early diagnosis and personalized treatment for patients at risk of serious lung disorders.
• Identify molecular markers to reduce morbidity and mortality after stem cell transplantation.
• Design experiments and analyze results for publication.
• Contribute to protocol studies and budget/regulatory reports as required.
• Collaborate with PI and cross-functional teams on projects.

Skills

Five years experience

Experimental design

Statistical analysis

Scientific publication writing

Protein assays (-omic platforms)

Single-cell sequencing

Data interpretation

Manuscript preparation

Education

Master's degree in Biology/Immunology

Relevant field experience

Job description

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations nationally and abroad. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

• Paid Time Off (Including Holidays)
• Employee Referral Bonus
• 401K Match
• Tuition reimbursement and professional development opportunities
• Flexible Spending Accounts:
  • Healthcare (FSA)
  • Parking Reimbursement Account (PRK)
  • Dependent Care Assistant Program (DCAP)
  • Transportation Reimbursement Account (TRN)

Position Overview

Axle is seeking a Research Biologist to serve as a senior research scientist in the conduct and leadership of research focused on immunologic lung injury, using advanced molecular techniques — including next‑generation sequencing, cell‑free DNA and cell‑free RNA analysis, and high‑density proteomics platforms — to support early diagnosis of lung injury, disease monitoring, and personalized treatment for patients who have or are at risk of serious lung disorders. This role supports detection and analysis of novel molecular markers to help reduce patient morbidity and mortality from immunologic lung disease following human stem cell transplantation. A Master's degree in Biology, Immunology, or a relevant field is required, along with at least five years of relevant scientific experience, the ability to design experiments and analyze results with appropriate statistical analysis, and the ability to write methods and results sections for high‑quality scientific publications.

Field of Study

Biology, Immunology, or a relevant field

Skills

• At least five (5) years of relevant scientific experience
• Ability to perform next‑generation sequencing, cell‑free DNA analysis, cell‑free RNA analysis, and high‑density proteomics platform assays, as well as learn other assays as assigned
• Ability to design experiments to meet the requirements of the principal investigator
• Ability to analyze results and present them with appropriate statistical analysis
• Ability to write methods and results sections for high‑quality scientific publications
• Work products and documents related to performing experiments and procedures, including but not limited to cell‑free DNA, cell‑free RNA, and a variety of -omic platforms — Upon Request
• Work products and documents related to recording and interpreting experimental research data — Upon Request
• Computer‑generated work, including preparing manuscript drafts for publication — Upon Request
• Work products and documents related to providing reports of research activities — Upon Request
• Preliminary reports related to budget and regulatory activities — Upon Request

Statement of Work Details

• Serve as a Biologist and senior research scientist in the conduct and leadership of research focusing on immunologic lung injury
• Use multiple advanced molecular techniques — including next‑generation sequencing, cell‑free DNA and cell‑free RNA analysis, and high‑density proteomics platforms — to support early diagnosis of lung injury, disease monitoring, and personalized treatments for patients who have or are at risk of serious lung disorders
• Provide detection and analysis of novel molecular markers to support reducing patient morbidity and mortality due to immunologic lung disease following human stem cell transplantation
• Identify causative immunologic mechanisms (cells and molecules) in each patient to direct further therapeutic interventions related to autoimmune‑associated lung injury after hematopoietic stem cell transplantation
• Support the "Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic Stem Cell Transplantation" protocol (001742-H) by performing single‑cell sequencing and high‑density proteomic analysis of blood and lung cells to help define mechanisms of altered lung function and identify patients at high risk of life‑threatening lung injury
• Support the "Quantitative Autoantibody Levels and Proteomic Endotypes in Myositis‑Interstitial Lung Disease" study (B2B Award 1167415) by performing high‑density proteomic assays (e.g., proximal extension assay) and quantitative autoantibody assays to characterize proteomic endotypes and identify trends in autoantibody levels and protein signatures in response to immunosuppressive therapy
• Support other research projects as assigned

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment‑based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: [e-mail]

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

This role has a market‑competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

Salary Range

$120,000 - $130,000 USD