Research Associate, Molecular & Cellular Immunology

Stylus Medicine, Inc.; Cambridge, Northern (MA, KY); Hybrid; USD 70,000 - 100,000; Full time

Job summary

Stylus Medicine is seeking a Research Associate to join the Molecular and Cellular Immunology team. The role involves generating nucleic acid materials and performing in vitro cell experiments to advance genetic medicines delivered through non-viral methods.

You will collaborate with cross-functional teams on the front lines of innovation and transformational therapies, conducting in vitro T cell experiments, cloning, preparing nucleic acids/LNPs, analyzing data, and communicating findings while

Qualifications

• Bachelor’s degree in Biology, Bioengineering, Immunology, or a related field.
• Hands-on molecular biology experience, including PCR, cloning, bacterial transformations, minipreps, maxipreps, and in vitro transcription.
• Hands-on mammalian cell culture expertise, including culturing tumor cell lines and primary T cells/PBMCs, co-culture experiments, flow cytometry, and genomic DNA extraction.
• Familiarity producing targeted LNPs and/or working with CAR-T cells is preferred.
• Demonstrated ability to execute, interpret, and troubleshoot experiments, both independently and collaboratively.
• Experience maintaining meticulous records, including documenting and maintaining an organized lab notebook, lab inventory, and experimental results.
• Excellent communication skills, with a team-first mindset and the ability to convey technical information.
• Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment.
• Enthusiasm and curiosity to learn and apply new lab techniques across a variety of sub-disciplines.

Responsibilities

• Perform in vitro T cell experiments to evaluate efficiency of recombinase-based engineering strategies and characterize the functional ability of resulting CAR-T cells
• Perform cloning and prepare nucleic acid and/or LNPs to support cell culture experiments
• Analyze and interpret data and produce data reports to inform project direction
• Effectively communicate findings to internal teams
• Maintain detailed and accurate laboratory records in compliance with data integrity and documentation standards

Skills

Molecular biology

Cell culture

PCR

Cloning

Flow cytometry

Data analysis

Education

Bachelor’s degree in Biology, Bioengineering, Immunology, or related field

Tools

LNP formulation

CAR-T technology

Job description

Research Associate, Molecular & Cellular Immunology

About the Role:

Stylus Medicine is seeking a highly motivated and collaborative Research Associateto join the Molecular and Cellular Immunology team. In this role, the Research Associate will assist in generating nucleic acid materials and performing in vitro cell experiments, supporting the advancement of genetic medicines that leverage engineered recombinases delivered through non-viral methods. Working closely with cross-functional teams, this is a unique opportunity to work on the front lines of innovation and contribute to the advancement of transformational therapies.

Key Responsibilities & Accountabilities:

Perform in vitro T cell experiments to evaluate efficiency of recombinase-based engineering strategies and characterize the functional ability of resulting CAR-T cells

Perform cloning and prepare nucleic acid and/or LNPs to support cell culture experiments

Analyze and interpret data and produce data reports to inform project direction

Effectively communicate findings to internal teams

Maintain detailed and accurate laboratory records in compliance with data integrity and documentation standards

Qualifications & Skills:

Bachelor’s degree in Biology, Bioengineering, Immunology, or a related field

Hands-on molecular biology experience, including PCR, cloning, bacterial transformations, minipreps, maxipreps, and in vitro transcription

Hands-on mammalian cell culture expertise, including culturing tumor cell lines and primary T cells/PBMCs, co-culture experiments, flow cytometry, and genomic DNA extraction

Familiarity producing targeted LNPs and/or working with CAR-T cells is preferred

Demonstrated ability to execute, interpret, and troubleshoot experiments, both independently and collaboratively

Experience maintaining meticulous records, including documenting and maintaining an organized lab notebook, lab inventory, and experimental results

Excellent communication skills, with a team-first mindset and the ability to convey technical information

Highly collaborative working style and ability to adapt in a fast paced, rapidly developing environment

Enthusiasm and curiosity to learn and apply new lab techniques across a variety of sub-disciplines

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