Research Associate I

askbio; Durham (NC); On-site; USD 45,000 - 60,000; Full time

Job summary

AskBio Inc. is seeking a Research Associate I, Histotechnologist, to develop, validate and execute histological assays including immunohistochemistry and RNAscope/BaseScope for preclinical and clinical programs. This on-site role supports tissue processing and quality documentation under the Senior Scientist.

The position involves histology techniques, cryo‑sectioning, and collaboration in a fast-paced, deadline-driven environment at our Morrisville RTP campus.

Qualifications

• Bachelor's degree in biological sciences or related field.
• Basic histology experience, and cryo‑sectioning/microtomy experience on cryostat/sliding microtome
• Basic laboratory skills- Pipetting, reagent prep, lab documentation, and good laboratory practices

Responsibilities

• Perform manual and automated immunohistochemical staining
• Perform manual and automated in situ hybridization (RNAscope/BaseScope) staining
• Perform routine histological staining
• Equipment maintenance
• Maintain accurate records with Good Documentation Practices
• Comply with established SOPs, established laboratory procedures and policies
• Ensure lab areas are well organized, and supplies are available and safety protocols are followed
• Perform routine histological procedures for FFPE and cryo samples to include tissue trimming, sample processing, embedding, and sectioning
• High quality microscopy slide production for microscopic examination by a pathologist or investigator

Skills

Histology techniques

Immunohistochemistry

In situ hybridization

Microscopy

Education

Bachelor's degree in biological sciences

Tools

Cryostat

Microtome

Imaging analysis

MS Office

Job description

AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life‑saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical‑stage pipeline that includes investigational therapeutics for congestive heart failure, limb‑girdle muscular dystrophy, multiple system atrophy, Parkinson’s disease, and Pompe disease. AskBio’s gene therapy platform includes Pro10™, an industry‑leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre‑clinical and clinical testing.

Our vision: Pioneering science to create transformative molecular medicines.

Our mission: Lead innovative science and drive clinical outcomes to transform people’s lives.

Our principles:

• Advance innovative science by pushing boundaries.
• Bring transformative therapeutics to patients in need.
• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
• Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
• Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
• Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.

Position Summary

The Research Associate I, Histotechnologist, will report to the Senior Scientist, Biodistribution Lead, and will participate in the development, validation and execution of histological assays, including immunohistochemistry, RNAscope/BaseScope, routine histology stains in support of pre‑clinical and clinical stage programs. This is an on‑site lab‑based position in Morrisville, NC and prior experience with tissue processing and immunohistochemistry is preferred. The ideal candidate would have knowledge of histology techniques. Candidates may also have opportunities to learn different techniques for protein, DNA and RNA assessment on tissue sections.

This position is based in RTP, North Carolina and will report to a Senior Scientist.

Job Responsibilities

• Perform manual and automated immunohistochemical staining
• Perform manual and automated in situ hybridization (RNAscope/BaseScope) staining
• Perform routine histological staining
• Equipment maintenance
• Maintain accurate records with Good Documentation Practices
• Comply with established SOPs, established laboratory procedures and policies
• Ensure lab areas are well organized, and supplies are available and safety protocols are followed
• Perform routine histological procedures for FFPE and cryo samples to include tissue trimming, sample processing, embedding, and sectioning
• High quality microscopy slide production for microscopic examination by a pathologist or investigator

Minimum Requirements

• Bachelor’s degree in biological sciences or related field
• Basic Laboratory skills- Pipetting, reagent prep, lab documentation, and good laboratory practices
• Basic histology experience, and cryo‑sectioning/microtomy experience on cryostat/sliding microtome

Preferred Education, Experience and Skills

• Experience in routine histology
• Experience in histological and immunohistochemical staining
• Experience in in situ hybridization
• HT or HTL certification or willingness to obtain the certification within 1 year of employment
• Excellent manual dexterity, attention to detail, and the willingness to work in a team‑based deadline‑driven atmosphere
• Ability to multitask among multiple projects and teams and work independently in a fast‑paced, highly interactive environment
• Self‑motivated, organized, capable of working independently and in a collaborative environment
• Excellent interpersonal skills with the ability to interact effectively with people, internally and externally
• Good judgment and innovation to achieve a solution within standard procedures
• Excellent written and verbal communication skills
• Knowledge of Microsoft Office Suite (Word, Outlook, Excel, PowerPoint)
• Experience with image analysis

AskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‑related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at [phone] or sending us an email at [e-mail].

Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio, through any medium, will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio, no fee or payment of any kind will be paid to the agency.