Research Associate, Automation & Assays

Prime Medicine, Inc.; Cambridge (MA); On-site; USD 72,000 - 80,000; Full time

Job summary

Prime Medicine, Inc. is seeking a Research Associate to join the Automation & Assays team within our Technical Development & Operations group to support high-throughput testing of research and process development samples using automated liquid handling systems.

The position emphasizes hands-on bench work, strict SOP adherence, and data recording in Benchling, with collaboration across programs and clear opportunities to grow in industrial biotechnology.

Qualifications

• High-school diploma or GED required; Associate’s degree preferred.
• 3–5+ years of hands-on wet-lab experience following SOPs.
• Proficiency with pipetting, dilutions and solution preparation.
• Experience with plate-based assays (ELISA or cell-based) is a plus; prior use of automated equipment is a plus.
• Strong attention to detail and data integrity.
• Able to manage time effectively and work in a fast-paced team environment.

Responsibilities

• Perform routine testing and analysis of R&D samples on automated systems.
• Follow SOPs, SOEs, and assay procedures; escalate deviations as needed.
• Record work accurately in Benchling per data integrity practices.
• Prepare reagents, buffers, and assay-ready plates; maintain cell cultures.
• Support lab operations: inventory management, consumables, and equipment upkeep.
• Generate basic data summaries and present results to the team.
• Support reagent and sample logistics: receipt, labeling, and storage.
• Contribute to a safe, compliant lab and learn new skills and processes.

Skills

Pipetting

Dilutions

Solution preparation

Data integrity

ELISA

Cell-based assays

Independent work

Attention to detail

Education

High-school diploma or GED

Associate’s degree in Biology/Biochemistry or related life-science field preferred

Tools

Benchling

Automated liquid handling systems

ELISA plate reader

Job description

Company Overview

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Position Overview

The Automation & Assays team, as part of the Technical Development & Operations (TDO) organization, is seeking a Research Associate to support the reliable, high-throughput testing of research and process development samples. This is a hands-on, execution-focused role centered on running established biochemical, ELISA, and cell-based assays on automated liquid handling systems, and on keeping the lab and its reagents ready for daily operations. Working under the guidance of scientists and engineers on the team, the Research Associate will follow established SOPs and assay procedures to generate high-quality, well-documented data across multiple programs.

This position provides an excellent entry point into an industrial biotechnology lab, with the opportunity to learn a diverse range of assays and automated workflows. The ideal candidate is dependable, detail-oriented, and comfortable executing routine work accurately and consistently in a fast-paced, team-based environment.

Key Responsibilities

• Perform routine testing and analysis of R&D samples using established biochemical, ELISA, and cell-based assays on automated liquid handling systems
• Execute assays by following Standard Operating Procedures (SOPs), Standard Operating Environments (SOEs), and assay procedures, escalating deviations or unexpected results to senior team members
• Record experimental work accurately and completely in the electronic lab notebook (Benchling) in accordance with Data Integrity principles and good documentation practices
• Prepare reagents, buffers, and assay-ready plates; maintain cell cultures for routine assay support under established protocols
• Support lab operations through inventory management, consumable and reagent restocking, equipment upkeep, and general lab organization and cleanliness
• Generate basic data summaries and present results to the team as needed
• Support critical reagent and sample logistics, including receipt, labeling, and storage
• Contribute to a safe, compliant, and well-organized laboratory; willingly learn new skills, assays, and processes

Qualifications / Requirements

• High-school diploma or GED required; Associate’s degree in Biology, Biochemistry, or a related life-science field preferred
• 3 - 5+ years of hands-on work experience; running wet-lab based diagnostics, or precision work, and following SOPs
• Proficiency in core wet-lab techniques (accurate pipetting, dilutions, basic solution preparation)
• Familiarity with plate-based assays (ELISA, cell-based, or biochemical) is a plus; prior use of automated equipment and instruments is a plus
• Strong attention to detail and a demonstrated commitment to data integrity and accurate record-keeping
• Able to manage time effectively, prioritize routine tasks, and work reliably both independently and as part of a team in a fast-paced environment
• Dependable, curious, highly organized, with a can-do attitude and a genuine passion for helping patients

Prime Medicine is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability, protected veteran status, or any other characteristic protected by law.

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks.

Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range

$72,000 — $80,000 USD

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.