Proteomics Scientist: Native & Top-Down MS

Stowers Institute for Medical Research; Kansas City (MO); On-site; USD 110,000 - 170,000; Full time

Job summary

The Stowers Institute for Medical Research seeks an experienced Scientist to join the Systems Mass Spectrometry Technology Center, advancing native and top-down proteomics workflows across diverse programs. The role focuses on experimental and analytical expertise, collaboration with researchers, and leading data analysis for complex proteoform studies.

The candidate will operate and develop cutting-edge MS methods, consult on experimental design, and train users in native/top-down approaches

Qualifications

• Masters is the minimal degree, PhD preferred in Chemistry, Biochemistry, Proteomics or related field.
• Hands-on experience with native and/or top-down mass spectrometry of proteins and protein complexes.
• Strong background in high-resolution MS instrumentation and protein-level separations (LC/CE).
• Proven proteomics data analysis expertise including intact mass deconvolution and proteoform assignment.

Responsibilities

• Design, execute, and optimize native and top-down proteomics experiments.
• Operate, maintain, and troubleshoot high-resolution mass spectrometers for native/top-down workflows.
• Develop sample prep, separation, and MS acquisition methods to preserve proteoforms.
• Perform advanced data analysis and interpretation of proteoform datasets.

Skills

native top-down MS

high-resolution MS

proteomics data analysis

sample preparation

data interpretation

Education

Master's degree minimum

PhD preferred

Tools

ProSight

TDPortal

TopPIC

BioPharma Finder

UniDec

Job description

The Stowers Institute for Medical Research seeks an experienced Scientist to join the Systems Mass Spectrometry Technology Center, advancing native and top-down proteomics workflows across diverse programs. The role focuses on experimental and analytical expertise, collaboration with researchers, and leading data analysis for complex proteoform studies.

The candidate will operate and develop cutting-edge MS methods, consult on experimental design, and train users in native/top-down approaches