Project Manager, Clinical Portfolio

1001 Syneos Health, LLC; Morrisville (NC); Hybrid; USD 100,000 - 130,000; Full time

Job summary

Syneos Health in Morrisville, NC is seeking a Project Manager for the Clinical Portfolio to independently plan, manage and deliver initiatives across the Clinical Future Operating Model Portfolio. This role provides structured project management discipline across transformation, operating model and cross-functional clinical initiatives.

The Project Manager owns delivery of agreed scope, timelines, RAID, reporting and stakeholder coordination, working closely with executives, business owners,

Qualifications

• Experience independently managing projects, transformation initiatives or cross-functional delivery work.
• Strong project management skills across planning, execution, RAID, reporting and governance.
• Ability to work independently, drive delivery and manage multiple priorities.
• Experience preparing executive summaries, governance materials or leadership reporting.
• Experience in healthcare, life sciences, clinical operations or consulting.

Responsibilities

• Independently manage assigned clinical portfolio initiatives from mobilisation through delivery, closure and handover.
• Develop and maintain project plans, milestones, RAID logs, action logs, decision logs and dependency trackers.
• Drive day-to-day execution, ensuring workstreams remain aligned to scope, timelines, governance expectations and delivery commitments.
• Lead project meetings, workstream check-ins and stakeholder forums to drive progress, resolve blockers and maintain accountability.
• Coordinate cross-functional teams, including business owners, workstream leads, SMEs and enabling functions.
• Define and maintain clear project scope, objectives, deliverables, roles, success measures and ownership.
• Identify, manage, document, and elevate risks, issues, assumptions and dependencies in a timely and decision-ready manner.
• Prepare executive summaries, project status updates and governance inputs.
• Real-time maintenance of accurate and current project information in Smartsheet and agreed systems of record.
• Partner with portfolio leadership to align risks, dependencies, escalations and decisions to governance requirements.
• Drive delivery discipline through action tracking, milestone follow-up, decision management and escalation.
• Support KPI and benefits tracking in partnership with the Value Realisation Office.
• Partner with Business to embed change impact, readiness, learning, adoption and hyper care into delivery.
• Support process mapping, RACI clarification, handoff identification and transition planning where required.
• Ensure implementation and project closure activities are completed.
• Manage confidentiality requirements for restricted or sensitive initiatives.
• Contribute to continuous improvement of PM templates, Smartsheet toolkits, governance standards and ways of working.

Skills

Project management

RAID management

Governance

Stakeholder management

Independent work

Planning & scheduling

Tools

Smartsheet

Job description

Project Manager, Clinical Portfolio Syneos Health

Project Manager, Clinical Portfolio Syneos Health is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress. Every day we perform better because of how we work together, as one team, each the best at what we do. We bring together talented experts across a broad spectrum of business critical corporate functions. Every role plays an essential part in enabling our customers to achieve their goals. Our teams are agile, collaborative, and committed to delivering—for each other, for our customers, and ultimately for the people who rely on the services we support. Discover what your 25,000 future colleagues already know: Why Syneos Health

• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to building an inclusive culture - where you can authentically be yourself. Central to this is our purpose - Driven to Deliver - which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone's life.
• We are continuously building the company we all want to work for and our customers want to work with.
• Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress.

Job Responsibilities

Job Summary

The Project Manager is responsible for independently planning, managing and delivering assigned initiatives across the Clinical Future Operating Model Portfolio. This role provides structured project management discipline across transformation, operating model and cross-functional clinical initiatives. The Project Manager owns delivery of agreed scope, timelines, milestones, Risk, Issues, Action and Decision Log (RAID), reporting and stakeholder coordination, working closely with Accountable Executives, business owners, workstream leads, Subject Matter Experts (SMEs) and enabling functions. The role is expected to operate independently, drive accountability across workstreams, elevate decision-ready issues, and support initiatives from mobilisation through delivery, closure and transition to business ownership.

Core Responsibilities

1. Independently manage assigned clinical portfolio initiatives from mobilisation through delivery, closure and handover.
2. Develop and maintain project plans, milestones, RAID logs, action logs, decision logs and dependency trackers.
3. Drive day-to-day execution, ensuring workstreams remain aligned to scope, timelines, governance expectations and delivery commitments.
4. Lead project meetings, workstream check-ins and stakeholder forums to drive progress, resolve blockers and maintain accountability.
5. Coordinate cross-functional teams, including business owners, workstream leads, SMEs and enabling functions.
6. Define and maintain clear project scope, objectives, deliverables, roles, success measures and ownership.
7. Identify, manage, document, and elevate risks, issues, assumptions and dependencies in a timely and decision-ready manner.
8. Prepare executive summaries, project status updates and governance inputs.
9. Real-time maintenance of accurate and current project information in Smartsheet and agreed systems of record.
10. Partner with portfolio leadership to align risks, dependencies, escalations and decisions to governance requirements.
11. Drive delivery discipline through action tracking, milestone follow-up, decision management and escalation.
12. Support KPI and benefits tracking in partnership with the Value Realisation Office.
13. Partner with Business to embed change impact, readiness, learning, adoption and hyper care into delivery.
14. Support process mapping, RACI clarification, handoff identification and transition planning where required.
15. Ensure implementation and project closure activities are completed.
16. Manage confidentiality requirements for restricted or sensitive initiatives.
17. Contribute to continuous improvement of PM templates, Smartsheet toolkits, governance standards and ways of working.
18. Provide business flex PM support where structured project management capability is required.
19. Perform other work-related duties as assigned.

Additional Qualifications

• Experience independently managing projects, transformation initiatives or cross-functional delivery work.
• Strong project management skills across planning, execution, RAID, reporting and governance.
• Ability to work independently, drive delivery and manage multiple priorities.
• Strong organisation, attention to detail and stakeholder management skills.
• Ability to turn ambiguous business asks into clear plans, actions and ownership.
• Experience preparing executive summaries, governance materials or leadership reporting.
• Experience managing risks, issues, dependencies, decisions and escalations.
• Experience using project management, reporting or portfolio tools.
• Ability to influence and drive accountability across teams without direct authority.
• Understanding of change, readiness, adoption, training and implementation needs.
• Experience in healthcare, life sciences, clinical operations or consulting.
• Experience supporting transformation portfolios or