Program Manager - Technical Operations

neurocrine; San Diego (CA); On-site; USD 120,000 - 190,000; Full time

Job summary

Neurocrine Biosciences in San Diego is seeking a Program Manager, Technical Operations to lead planning and execution of cross‑functional development programs across CMC disciplines.

The role translates program objectives into integrated execution plans, establishes governance and rhythms, and coordinates six or more technical sub‑teams with clear ownership and risk management.

Responsibilities

• Lead integrated planning and execution of Technical Operations and CMC programs through milestones.
• Develop and communicate integrated program plans, timelines, milestones, and dependencies.
• Establish governance, cadence meetings, decision logs, action trackers, and status reports.
• Monitor execution, identify schedule risks, cross-functional constraints, and issues.
• Partner with SMEs to evaluate options, mitigation strategies, and issue resolution.
• Facilitate scenario planning to inform timelines, sequencing, and execution priorities.
• Maintain clear documentation of assumptions, decisions, risks, actions, and accountabilities.
• CMC/Technical Operations integration across API, analytics, manufacturing, QA, and regulatory.
• Translate functional strategies into coordinated program-level plans and milestones.
• Support development and maintenance of integrated CMC timelines and strategies.

Job description

Who We Are:

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com , and follow the company on LinkedIn , X , Facebook and YouTube . ( *in collaboration with AbbVie )

At Neurocrine, strong leadership drives both business results and team success. We look for leaders who think strategically, anticipate what's ahead and set clear direction, while building and empowering high-performing teams. Successful leaders foster an environment where people are motivated to do their best work and deliver meaningful, measurable impact through sound decision-making and accountability.

About the Role:

The Program Manager, Technical Operations supports the planning, execution, and operational effectiveness of Technical Operations programs across the development portfolio. The role provides program management leadership for complex, multidisciplinary initiatives and serves as a key operational partner to CMC functional leaders, program teams, and cross-functional stakeholders.

The Program Manager is responsible for translating program objectives into integrated execution plans, establishing effective governance, and operating rhythms, identifying and managing dependencies and risks, and ensuring transparency and accountability across participating functions. The role may coordinate six or more technical sub-teams or workstreams within the scope of an assigned program and ensures that strategy, critical-path activities, interdependencies, decisions, and emerging risks are clearly communicated to appropriate stakeholders.

This position requires a strong understanding of pharmaceutical development and the interactions among core CMC disciplines, including Drug Substance/API Development, Analytical Development, Drug Product/Pharmaceutical Development, Manufacturing, Supply Chain, Quality, and CMC Regulatory. The Manager works cross-functionally with partners in Research, Clinical Development, Regulatory Affairs, Quality, Finance, and other functions to ensure Technical Operations activities support broader program and company objectives.

Your Contributions (include, but are not limited to):

• Program and Project Management
  Lead the integrated planning and execution of assigned Technical Operations and CMC programs, initiatives, and major workstreams from development planning through key program milestones


• Develop, maintain, and communicate integrated program plans, timelines, milestones, critical paths, dependencies, decision points, and key deliverables


• Establish and manage appropriate meeting cadences, governance forums, decision logs, action trackers, and status reporting mechanisms


• Monitor execution against agreed plans and proactively identify schedule risks, resource constraints, cross-functional dependencies, and emerging issues


• Partner with functional subject-matter experts to evaluate options, develop mitigation strategies, and support timely resolution or escalation of issues


• Facilitate scenario planning and trade-off discussions to enable informed decisions related to timelines, sequencing, dependencies, and execution priorities


• Maintain clear documentation of key program assumptions, decisions, risks, actions, and accountabilities


• CMC and Technical Operations Integration
  Apply working knowledge of CMC development disciplines-including API/drug substance, analytical development, pharmaceutical/drug product development, manufacturing, supply chain, quality, and regulatory activities-to effectively integrate cross-functional plans


• Understand upstream and downstream impacts of Technical Operations activities and proactively connect interdependent work across functions


• Partner with technical leaders to translate functional strategies and technical activities into coordinated program-level plans and milestones


• Facilitate alignment between Technical Operations activities and broader Research, Clinical Development, Regulatory, Quality, and portfolio objectives


• Support development and maintenance of integrated CMC strategies, timelines, an