ProFound Therapeutics: Proteomics Co-Op

Flagship Pioneering Co-Op Program; Cambridge (MA); On-site; USD 34,000 - 48,000; Full time

Benefits offered by this job

Build alongside founders

Future opportunities across Flagship

Collaborative & entrepreneurial team

Ownership of real projects

Competitive compensation

Job summary

ProFound Therapeutics, part of Flagship Pioneering’s ecosystem, seeks a Co‑Op with protein biochemistry and/or mass spectrometry expertise for the Proteomics team. You will gain hands-on experience in sample prep, LC‑MS/MS analysis, and workflow development, contributing to a multidisciplinary environment in a fast-paced biotech startup.

Under supervision of senior scientists, you’ll develop technical skills, document results, and present findings while collaborating across genomics,

Qualifications

• Pursuing a Bachelor’s or Master’s degree in biochemistry, chemistry, analytical chemistry, cell biology, or a related field.
• Coursework or hands‑on laboratory experience in protein biochemistry, cell biology, proteomics, or mass spectrometry.
• Excellent communication and presentation skills; able to convey technical information clearly.

Responsibilities

• Serve as a contributor to the Proteomics team, helping discover new therapeutics and validate targets.
• Support development of workflows using alternative proteases to improve protein sequence coverage.
• Assist with optimization of surfaceome enrichment and profiling of cell-surface and membrane proteins.
• Assist with optimization of secretome proteomics workflows for conditioned media and minimize serum interference.
• Assist with ubiquitylation screening including enrichment and analysis of ubiquitin‑remnant peptides.
• Perform proteomics sample preparation, LC‑MS/MS analysis, data interpretation, and quality control with supervision.
• Troubleshoot methods, document results, and contribute to reproducible protocols.
• Organize and maintain experimental records in Benchling for review.
• Report experimental plans and results to the scientific team.
• Review relevant literature to contribute to new ideas and methods for discovery.

Skills

Protein biochemistry

Mass spectrometry

Scientific communication

Education

Bachelor’s or Master’s in biochemistry/chemistry/analytical chemistry/cell biology

Tools

LC‑MS/MS

Benchling

Job description

This position is open exclusively to current Northeastern University Co-Op students.

Work Period:

January 2027 to June 2027. This is a full - time, 40 hours per week position with 5 days in office.

About ProFound Therapeutics

ProFound Therapeutics Inc. is a privately held, early-stage biotechnology company with the vision to revolutionize the human therapeutic landscape. ProFound has recently made the news by being included in the Fierce Biotech’s list of the hottest Biotech companies. ProFound Therapeutics Inc. was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources, and grows first-in-category life sciences companies. Since 2000, Flagship has created over 75 groundbreaking companies that are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics (NASDAQ:MRNA), Seres Therapeutics (MCRB), Syros Pharmaceuticals (SYRS), Evelo Biosciences (EVLO), Kaleido Biosciences (KLDO), and Indigo Agriculture. ProFound Therapeutics, Inc. is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire an exceptional scientist to join our team.

About Flagship Pioneering

ProFound Therapeutics was founded by Flagship Pioneering’s venture creation engine that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the company’s Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com .

FlagshipPioneering Co-Op Program

Welcome to Flagship Pioneering Co-Op Program for the cohort dreaming big and taking courageous leaps. You’ll join fellow peers across our ecosystem of companies and learning firsthand how we build first-in-category companies. You’ll have access to enrichment sessions , a dedicated professional development track , and a mentor that help guide you toward your next step. By the end, you will carry on a meaningful project outcome , a genuine network , and a front-row view of how Flagship pioneer new ventures that change the world.

The Role

ProFound Therapeutics is seeking an innovative and highly motivated Co-Op with experience in protein biochemistry and/or mass spectrometry to play a vital role in the company’s Proteomics team. Under the supervision of senior scientists on the Proteomics team, this individual will receive structured training and hands‑on experience in proteomics sample preparation, LC‑MS/MS analysis, and the development of workflows for challenging protein classes. This individual will contribute scientific and technical expertise to a multidisciplinary team, emphasizing conceptualization, experimentation, data analysis, presentation, and strategic planning. The ideal candidate for this position will have coursework or early research experience in biochemistry, analytical chemistry, cell biology, or a related discipline and be enthusiastic and capable of working in a multidisciplinary (e.g. genomics, bioinformatics, protein biochemistry) team in the biosciences. The candidate should be able to work independently and as part of a team in a fast‑paced entrepreneurial setting. The Co‑Op is designed to complement the candidate’s academic training and provide exposure to industry‑based research and therapeutic development.

Key Responsibilities

Serve as a contributor to the Proteomics team, whose mission is to discover new therapeutics and validate new therapeutic targets

Support the development of workflows using alternative proteases to improve protein sequence coverage and detection of challenging proteins

Assist with the optimization of surfaceome enrichment and profiling of cell-surface and membrane proteins

Assist with the optimization of secretome proteomics workflows for conditioned media, including strategies to minimize serum interference and intracellular contamination

Assist with the optimization of ubiquitylation screening, including enrichment and analysis of ubiquitin‑remnant peptides

Perform proteomics sample preparation, LC‑MS/MS analysis, data interpretation, and quality control, supported by senior scientists

Troubleshoot methods, document results, and contribute to establishing reproducible protocols

Organize and maintain experimental records in Benchling for review

Report experimental plans and results to the scientific team

Proactively review literature to contribute to new ideas and methods/technologies for discovery and therapeutic areas

Minimum Qualifications

Pursuing a Bachelor’s or Master’s degree in biochemistry, chemistry, analytical chemistry, cell biology, or a related field

Coursework or hands‑on laboratory experience in protein biochemistry, cell biology, proteomics, or mass spectrometry, and attention to detail

Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner

Strong collaborative skills with evidence of working in a team

Preferred Qualifications

Prior industry or academic research co‑op experience in proteomics, protein biochemistry, or mass spectrometry

Experience with LC‑MS/MS sample preparation

Coursework or research exposure to membrane proteins, secretome analysis, or post‑translational modification (PTM) enrichment

Familiarity with proteomics data analysis software

Confident execution, focused and team‑oriented with an ability to thrive in an entrepreneurial environment

Experience with data analysis using Graphpad Prism and Microsoft Excel

What We Offer

• Build alongside founders. You’ll work inside the same hypothesis‑driven process Flagship uses to conceive and launch first‑in‑category companies.
• This can be the start of a longer story. Strong co‑ops are considered for future opportunities across Flagship and its portfolio companies, not just for this one role.
• Work alongside people who left the safe path. Your colleagues are scientists, engineers, and operators who chose to build something new rather than join something already established.
• Take on real ownership. You’re contributing to ventures that are still being defined. Your work can shape real decisions, not just support them.
• Be paid like the contributor you are. Compensation reflects the real work you take on.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

The pay range for this role is $25 - $35 per hour. This role is a short‑term engagement that is not eligible for health and welfare benefits. Retirement benefits may be available after completing a set number of hours. Compensation and benefits information is based on ProFound Therapeutics’s good faith estimate as of the date of publication and may be modified in the future.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI‑assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [e-mail].

The pay range for this role is $25 - $35 per hour. This role is a short‑term engagement that is not eligible for health and welfare benefits. Retirement benefits may be available after completing a set number of hours. Compensation and benefits information is based on ProFound Therapeutics, Inc.’s good faith estimate as of the date of publication and may be modified in the future.

Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI‑assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact [e-mail].