Product Lead - Diagnostics

Radical Numerics; San Francisco (CA); On-site; USD 120,000 - 200,000; Full time

Job summary

Radical Numerics in San Francisco is seeking a senior role to drive diagnostics partnerships within clinical genomics. You will identify target labs and health systems, and lead negotiations to move deals from pilots to production.

You will collaborate with our science team to design validation studies, ensure data provenance and regulatory alignment (CLIA/CAP), and work with an applications engineer to close strategic contracts.

Qualifications

• Deep knowledge of clinical variant interpretation principles.
• Experience with ACMG/AMP variant classification criteria.
• Understanding of CLIA and CAP laboratory environments.
• Experience selling to clinical laboratories or diagnostics companies.

Responsibilities

• Originate and close partnerships with clinical genomics labs and health systems.
• Define studies and validation plans to support production use.
• Collaborate with engineering to specify data and documentation needs.
• Set pricing and negotiate with legal during contracts.

Skills

Clinical variant interpretation

ACMG criteria

AMP criteria

CLIA familiarity

CAP familiarity

Commercial sales experience

Biomedical labs experience

Job description

About Us

Radical Numerics is an AI research lab building general biological intelligence. Our mission is to master the code of life, and our purpose is to reduce human suffering. Our team created Evo, and started the field of generative genomics. Our work was featured on the cover of Science, and presented by our CEO on the main stage of TED2025. Evo was used to create the first AI gene therapy tool CRISPR-Cas9, and the first AI whole genome from scratch. Evo 2, featured in Nature, is the largest fully open source AI project across any domain. Radical Numerics is bringing the rigor of distributed systems, model architecture, and numerics research to the challenges of biology. We’ve redesigned the foundation model training stack to turn the world’s raw scientific data (e.g. biological sequences, experiments, and physical processes), into intelligible, generative models that can expand and accelerate what humanity can understand, design, and cure. The same generative breakthroughs that enable life‑saving cures also lowers the barrier to creating engineered threats and AI-generated bioweapons. We believe these forces are inseparable. Radical Numerics was founded to develop both the power to design and the responsibility to defend.

About the Role

You own the diagnostics side of our business. You identify where in clinical genomics companies, laboratories, and health systems our deals get funded, including product, R&D, and the laboratory itself. Our science team owns the model itself. You decide what we build on top of it so a clinical organization can run our scoring inside a test they have already validated. The people who evaluate us are bioinformatics teams and lab directors, and they don't move without validation on their own data, so you will have a lot of say in which studies we run. You should be comfortable building prototypes. You are paired with an applications engineer who builds production product, and you go into partner meetings together. You will carry a commercial target, weighted early toward getting a partner into production.

What You’ll Do

Decide which interpretation problems we solve and for whom, and what has to be true technically before a clinical organization will run our output in production. Originate and close partnerships with clinical genomics companies, laboratories, and health systems. You are measured on committed contract value and on partners running our scoring in production rather than in pilots. Design the studies that convert a clinical buyer. Blind retrospectives on solved cases, concordance against the tools they use today, and reclassification yield on their own backlog. Tell our engineering team what production use requires from us, including version pinning, provenance, and the documentation a partner's quality system needs. Flag early when an opportunity needs us to build something we do not have. Set pricing and structure with the Head of Product, and run the negotiation with our legal team.

What We’re Looking For

Depth in clinical variant interpretation. ACMG and AMP criteria, ClinVar and its limits, VUS reclassification, and what a lab director or genetic counselor needs from a call. You have sold into clinical laboratories or diagnostics companies and carried a number. Working fluency in CLIA, CAP, the laboratory developed test landscape, and what analytical validation asks of a software component inside an assay. You stay useful when the real objection is reimbursement, liability, or the buyer's own validation burden rather than the science. You want to own revenue, and you can run a long clinical sales cycle without going quiet inside it.

Nice to Have

You have worked inside a clinical laboratory or a diagnostics company. Experience across both germline and somatic interpretation. You understand how a new component inside an existing billable test gets funded.

Equal Employment Opportunity

Radical Numerics is committed to equal employment opportunity and does not discriminate in any employment opportunities or practices based on an individual's race, color, creed, gender (including gender identity and gender expression), religion (all aspects of religious beliefs, observance or practice, including religious dress or grooming practices), marital status, registered domestic partner status, age, national origin or ancestry (including language use restrictions and possession of a driver’s license issued under California Vehicle Code section 12801.9), natural hair, physical or mental disability, political affiliation, medical condition (including cancer or a record or history of cancer, and genetic characteristics), sex (including pregnancy, childbirth, breastfeeding or related medical condition), genetic information, sexual orientation, military and veteran status or any other consideration made unlawful by federal, state, or local laws. It also prohibits unlawful discrimination based on the perception that anyone has any of those characteristics, or is associated with a person who has or is perceived as having any of those characteristics.

E-Verify

Radical Numerics participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.