Process Engineer II

Asklepios BioPharmaceutical, Inc. (AskBio); North Carolina; On-site; USD 90,000 - 120,000; Full time

Benefits offered by this job

On-site at RTP

Competitive benefits

Job summary

AskBio Inc. is seeking a Process Engineer II to join the MSAT Process Engineering team at our RTP, NC headquarters.

You will support scale-up, technology transfer of gene therapy products into cGMP manufacturing for clinical production and commercial launch, and contribute to Phase III readiness. The role requires collaboration across functions to transfer processes, develop small-scale models, document protocols, analyze data, and ensure robust process control strategies.

Qualifications

• Bachelor’s degree in a scientific discipline with 2+ years biopharmaceutical experience, or higher degree.
• Hands-on upstream or downstream biomanufacturing laboratory experience.
• Experience with viral vectors and cGMP manufacturing operations.
• DOE methodology knowledge; JMP software preferred.

Responsibilities

• Collaborate with cross-functional teams to transfer small-scale gene therapy processes into MSAT and scale-up to cGMP manufacturing.
• Perform process characterization to define robustness and the process control strategy for PPQ campaigns.
• Develop and qualify small-scale models predictive of cGMP scale.
• Author protocols and reports; present results to stakeholders.
• Support investigations with data-driven root-cause analyses.

Skills

Upstream biomanufacturing

Downstream biomanufacturing

Viral vectors

DOE design of experiments

Data-driven problem solving

Strong communication

Travel up to 10%

Education

Bachelor’s degree in a scientific discipline

Master’s degree in a scientific discipline

High School Diploma with 6+ years biopharmaceutical experience

Tools

JMP Statistical Software

Microsoft Office Suite (Excel, Word, PowerPoint)

Job description

Process Engineer II

Aug 4, 2026

AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson’s disease, and Pompe disease. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing.

Our vision: Pioneering science to create transformative molecular medicines.

Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.

Advance innovative science by pushing boundaries.

Bring transformative therapeutics to patients in need.

Provide an environment for employees to reach their fullest potential.

Our values:

Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.

Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.

Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.

Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.

Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what’s right in every situation. Make clear commitments and follow through.

Position Summary

AskBio is seeking a Process Engineer II to join our MSAT Process Engineering team and support current and future commercialization efforts. This position supports scale-up, technology transfer of AskBio’s portfolio of gene therapy products into cGMP manufacturing for clinical production, process validation and commercial launch. The incumbent will onboard clinical programs into the MSAT laboratory, perform scale-up runs, and transfer programs to AskBio’s contract manufacturing facility. Additionally, this position will be responsible for performing Phase III clinical enabling activities including scale-down model development and qualification, process characterization, and process control strategy definition to enable process performance qualification (PPQ) readiness for both drug substance and drug product manufacturing campaigns. This position is highly collaborative and will require internal and external team interactions to ensure successful process scale-up, technology transfers, and cGMP manufacturing operations to ensure continuity of supply while adhering to global regulations and standards.

This role is based on-site at our RTP (Research Triangle Park) Headquarters in NC and reports to an Associate Director, MSAT.

Job Responsibilities

Collaborate with cross-functional teams to transfer small-scale gene therapy processes from Process Development into the MSAT laboratory and subsequently perform scale-up and transfer to the cGMP manufacturing scale

Perform process characterization experiments to generate robustness data and define the process control strategy for PPQ manufacturing campaigns. Contribute to process characterization experimental design and data analysis

Develop and qualify small-scale models that are predictive of the cGMP manufacturing scale

Author technical protocols and reports to support experimental work and maintain clear, organized electronic laboratory notebooks

Provide effective communication of experimental results in technical presentations with internal stakeholders

Support investigations by contributing technical expertise to root‑cause analyses and using a data‑driven approaches for driving issue resolution

Ensure the laboratory is clean, organized and maintained in an efficient working order, includes scheduling routine preventative maintenance/calibration of instruments/equipment, securing supplies and materials for experiments, and proper scheduling of laboratory work

Bachelor’s Degree in a scientific discipline with 2+ years of Biopharmaceutical Experience; OR Master’s Degree in a scientific discipline; OR High School Diploma with 6+ years of biopharmaceutical Experience

Hands‑on upstream or downstream biomanufacturing laboratory experience

Excellent written and verbal communication skills, with experience interacting with a range of internal stakeholder groups

Proficiency in using Microsoft Office Suite (Word, Excel, PowerPoint)

Highly motivated, organized, and disciplined, with a strong desire to contribute as part of a best‑in‑class, collaborative tech transfer team

Adaptable and eager to learn, thriving in a fast‑paced, highly interactive environment

Genuinely interested in building proficiency in upstream and downstream biomanufacturing operations, including process scale‑up, technology transfer, process characterization, and process control strategy development

Continuous improvement‑oriented, seeking opportunities to optimize process operations and performance through proactive problem solving

Open to domestic and international travel up to approximately 10%, as needed

Preferred Education, Experience and Skills

Experience with viral vectors

Experience supporting cGMP manufacturing operations

Knowledge of the Design of Experiment (DOE) methodology with an ability to design, execute, and analyze experiments with oversight. JMP Statistical Software proficiency is highly preferred

AskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job‑related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (919) 561‑6210 or sending us an email at [e-mail] .

Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio, through any medium, will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio, no fee or payment of any kind will be paid to the agency.

Asklepios BioPharmaceutical, Inc. (AskBio) is a pioneering gene therapy company focused on developing transformative treatments for various devastating diseases, driven by innovation and integrity.

Biotechnology Research Research Services Professional Services

Private Equity - Vida Ventures, TPG Capital Asia$235M

Apr 2019

Grant$2.5M

Grant$1.6M

Jan 2004

Footprint

Where they work

20 TW Alexander Dr, Suite 110, Research Triangle Park, North Carolina 27709, US 2929 Arch St, Philadelphia, Pennsylvania 19104, US Roslin Innovation Centre Easter Bush Campus, Edinburgh, Scotland EH25 9RG, GB 47, Boulevard de l'hôpital, Paris, Île-de-France 75013, FR Am Taubenfeld 21/1, Heidelberg, Germany 69123 , DE 2447 North Star Road, Upper Arlington, Ohio 43221, US