Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs

Amgen; Thousand Oaks (CA); On-site; USD 100,000 - 130,000; Full time

Benefits offered by this job

Comprehensive employee benefits package

Discretionary annual bonus program

Stock-based long-term incentives

Job summary

Amgen is seeking a Process Development Senior Scientist in Thousand Oaks to lead the development of synthetic processes for biologics and drug conjugates. You will work within a team of experts to innovate and implement drug substance manufacturing technologies.

Ideal candidates should possess a Ph.D. or relevant degree, along with strong skills in organic chemistry and bioconjugation, contributing to projects that make a real difference in patient lives.

Qualifications

• Strong background in organic chemistry and/or bioconjugation chemistry.
• Ph.D. in organic chemistry, chemical biology, or biochemistry preferred.
• Excellent written and verbal communication skills.

Responsibilities

• Invent synthetic routes and develop processes for antibody drug conjugate production.
• Drive technology innovation to improve sustainability and process efficiency.
• Contribute to regulatory documents and support regulatory filings.

Skills

Organic chemistry

Bioconjugation chemistry

Analytical characterization techniques

Project management

Education

Doctorate degree (PhD OR PharmD OR MD)

Master’s degree in relevant field

Bachelor’s degree with scientific experience

Tools

HIC-HPLC

LC-MS

RP-HPLC

Job description

Overview

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer biotech in our fight against the world’s toughest diseases. Amgen focuses on Oncology, Inflammation, General Medicine, and Rare Disease, reaching millions of patients each year. We are advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a team member, you’ll help make a lasting impact on patients’ lives as we research, manufacture, and deliver innovative medicines.

Our award-winning culture is collaborative, innovative, and science-based. If you have a passion for challenges and the opportunities within them, you’ll thrive as part of the Amgen team.

Position

Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs

What You Will Do

Let’s do this. Let’s change the world. In this vital role you will join our Drug Substance Technologies - Synthetics (DSTS) group at our Thousand Oaks campus. Amgen’s DSTS group within Process Development (PD) is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen's portfolio of synthetic and hybrid assets. Process chemists apply their synthetic training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late-stage development. The role includes developing innovative solutions to support chemical and bio-conjugation process development of hybrid modality drug candidates, including antibody drug conjugates, peptide antibody conjugates, synthetic peptides, and/or oligonucleotides. The successful candidate will provide technical expertise and translate developed processes toward manufacturing and commercialization. The candidate will be highly motivated, team-oriented, with a strong background in organic chemistry and/or bioconjugation chemistry and a track record of scientific innovation.

Key Responsibilities

• Work effectively with a diverse team of synthetic chemists, chemical engineers, and analytical chemists to invent synthetic routes and develop safe, robust, sustainable, and cost-effective processes for antibody drug conjugate, peptide antibody conjugates, synthetic peptides and/or oligonucleotide manufacturing
• Drive technology innovation in the synthesis, purification, and characterization of bioconjugates, oligonucleotides, and/or synthetic peptides
• Support cGMP manufacturing and technology transfer to internal manufacturing facilities and external contract manufacturers
• Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
• Ensure process performance through process understanding, modeling, and characterization
• Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, and recommendations
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and stay current in bioconjugation, antibody drug conjugates, oligonucleotides, peptides, and process chemistry and manufacturing
• Work independently in advancing projects and studies within required deadlines

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek is an individual with these qualifications.

Basic Qualifications

• Doctorate degree (PhD OR PharmD OR MD) and relevant post-doc where applicable
• OR
• Master’s degree and 3 years of scientific experience
• OR
• Bachelor’s degree and 5 years of scientific experience

Preferred Qualifications

• Ph.D. in organic chemistry, chemical biology or biochemistry with expertise in antibody drug conjugate, synthetic oligonucleotide, and/or synthetic peptide process development
• Post-doctoral experience in an academic laboratory or pharmaceutical/biotech industry
• Extensive hands-on expertise in the synthesis and purification of peptides, oligonucleotides, and/or antibody drug conjugates; experience with bioconjugation techniques
• Proficiency in analytical characterization techniques such as HIC-HPLC, SEC, LC-MS, IEX, and RP-HPLC
• Familiarity with laboratory automation, data analysis and visualization tools
• Track record of peer-reviewed publications and research presentations
• Ability to work in a dynamic, interdisciplinary environment to achieve results
• Excellent written and verbal communication skills; ability to multitask, plan, and follow through on complex projects
• A research summary included with CV is strongly encouraged

What You Can Expect From Us

We support your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on skills, experience, and qualifications.

In addition to base salary, Amgen offers a Total Rewards Plan, comprising health and welfare plans, retirement savings, work/life balance programs, and career development opportunities which may include:

• A comprehensive employee benefits package, including retirement and savings plans with company contributions, group medical/dental/vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting

Apply now and make a lasting impact with the Amgen team.

Website: careers.amgen.com

EEO and accommodations: Amgen is an Equal Opportunity employer. We will consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by law. We will provide reasonable accommodation to participate in the job application or interview process. Please contact us to request accommodation.