Process Development Senior Scientist

Biopharma Careers; Cambridge (MA); On-site; USD 126,000 - 171,000; Full time

Benefits offered by this job

Retirement plan

Medical, dental, vision coverage

Stock-based incentives

Flexible work options

Job summary

Amgen is seeking a Process Development Senior Scientist in the US to lead development, characterization, scale-up and support of drug substance processes for late-stage programs advancing from Ph II/III to commercialization. You will work in a cross-functional group with cell culture and purification scientists to deliver robust, scalable processes in a cGMP environment.

You will apply platform approaches, tackle drug substance challenges, and contribute to regulatory submissions, while

Qualifications

• PhD in Chemical Eng., Biochem., Biotech., Biomed., or related field.
• Experience in bioreactor process development or cell line development.
• Strong knowledge of current bioreactor technologies and data-driven development.

Responsibilities

• Develop, characterize, scale-up and support drug substance processes for commercial advancement.
• Collaborate with cell culture and purification scientists to advance pipeline.
• Deliver robust processes in a cGMP manufacturing environment.
• Prepare technical reports and support regulatory submissions as needed.

Skills

Leadership

Scientific communication

Cross-functional collaboration

Bioprocess understanding

Cell culture knowledge

Bioreactor development

Statistical analysis

DOE methods

Education

PhD in Life Sciences

Master’s degree + 2 years Life Sciences

Bachelor’s degree + 4 years Life Sciences

Tools

Bioreactor systems

Analytical instrumentation

DOE software

Job description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission, to serve patients living with serious illnesses, drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Process Development Senior Scientist

What you will do

• Let’s do this. Let’s change the world. In this vital role you will be responsible fordevelopment, characterization, scale-up and support of drug substance processes to enable commercial advancement of programs from Ph II/III clinical trials to marketingapplication.
• Work in a coordinated group in which cell culture and purification scientists work together to advance Amgen’s rich,excitingand dynamic pipeline. With Amgen’s biology first approach, the positionprovidesthe outstanding opportunity of being able to work on multiple modalities from antibodies and oncolytic viruses tobispecificsand siRNAs.
• The Pivotal Drug Substance Process Development organization at Amgen develops,characterizesand supports the commercialization ofbiologicsdrug substance manufacturing processes for all late-stage programs across the Amgen portfolio.
• Apply established platform approaches and problem-solving skills to rapidly tackle drug substance challenges and build robust processes with efficient experimentation.
• Drive innovationandutilizeout-of-the-box thinking to contribute to technology development.
• Expand and develop skills in cell culture and purification, thereby further contributing to theintegrated group.
• Participate in drug substance teams and collaborate cross functionally with analytical and drug product representatives to deliver drug substance manufacturing processes in a phaseappropriate manner.
• Deliverprocessamenableto cGMP operation and carry out results of drug substance in a cGMP manufacturing environment.
• Author, or provide direction for the authorshipof,technical report or CMC regulatory submissions which may require minimaladditionalediting.

What we expect of you

The professional we seek is a leader with these qualifications.

Basic Qualifications

• Doctorate degree
• OR
• Master’s degree and 2 years of Life Sciences experience
• OR
• Bachelor’s degree and 4 years of Life Sciences experience

Preferred Qualifications

• Ph.D. in Chemical Engineering, Biochemistry, Biotechnology, Bioengineering, Biomedical engineering, or Bioprocessing discipline or relevant experience in the pharmaceutical or related industry
• Experience in bioreactor process development or cell line development
• Scientific understanding of current bioreactor technologies, as well as the ability to explore and developnew approachesto further advance innovative bioreactor technologies
• Understanding of protein characteristics and critical attributesso as todirect bioreactor development and product/process control strategies
• Independently uncovering and resolving issues associated with cell culture and harvest and implementation of scientific projects
• Strong technical communication skills, both written and verbal, to interact effectively and appropriately with all stakeholders and document learned information, improvements, and value generated
• Motivated self-starter with excellent interpersonal and organizational skills
• Leadership experience of progressively increased scope and a demonstrated ability to inspire and lead a group of scientists to deliver on complex and challengingobjectivesin defined timelines
• Demonstrated eminence in the scientific community through a sustained record of peer reviewed publications
• Demonstrated success working with diverse team members in a dynamic, cross-functional environment
• Familiarity with design of experiments and statistical analysis of data
• Knowledge of license application and the drug development process
• Exposure to cGMP manufacturing and CMC components of regulatory submissions

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

. Salary Range

126,066.05USD -170,559.95USD