Process Development Senior Principal Scientist Bioconjugates

Amgen Inc. (IR); Thousand Oaks (CA); On-site; USD 158,000 - 213,000; Full time

Benefits offered by this job

Retirement plan

Bonus program

Stock-based incentives

Flexible work models

Job summary

Amgen Inc. (IR) in Thousand Oaks, CA seeks a Process Development Senior Principal Scientist to lead a bioconjugates team, develop efficient manufacturing processes for ADCs, and drive technology innovation.

The role requires deep expertise in bioconjugation and industrialization of manufacturing processes with a strong leadership track record. The successful candidate will guide cross-functional teams, contribute to regulatory filings, mentor staff, and ensure project milestones are met in a

Qualifications

• PhD/PharmD/MD with 3 years of scientific experience OR Master's with 6 years OR Bachelor's with 8 years.

Responsibilities

• Lead a multidisciplinary team of chemists and engineers in bioconjugate process development.
• Drive bioconjugation technology innovation and process understanding.
• Support cGMP manufacturing and tech transfer to GMP facilities.
• Develop strategies to ensure process performance via modeling and characterization.
• Coach and mentor team members and deliver timely project milestones.
• Collaborate cross-functionally to support regulatory filings.

Skills

Bioconjugation

Leadership

Process development

Cross-functional teamwork

Regulatory collaboration

Education

PhD in Chemistry/related field

PharmD

MD

BSc in science

Job description

Career Category Scientific Job Description

Process Development Senior Principal Scientist Bioconjugates

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

What you will do

Let’s do this. Let’s change the world.

In this vital role you will join Amgen’s DSTS group within Process Development (PD) is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen's exciting portfolio of synthetic and hybrid assets.

Process chemists within our team apply their training to invent synthetic routes and chemical processes to support drug substance manufacturing from early to late-stage development.

Amgen is currently seeking a talented Senior Principal Scientist who will lead a multidisciplinary team of chemists and chemical engineers in the development of efficient and sustainable manufacturing processes for bioconjugates, including antibody drug conjugates (ADCs), drive technology innovation, provide technical expertise, and develop and mentor staff within the organization.

The successful candidate for this role will be a people-centered leader with deep expertise in bioconjugation process development and industrialization of bioconjugation manufacturing processes with a proven track record of scientific innovation and leadership within the pharmaceutical industry.

The role will be located at our Thousand Oaks, California campus.

• Lead a multidisciplinary project team in the development of sustainable and cost-effective processes for bioconjugate manufacturing at all stages of clinical development
• Drive bioconjugation technology innovation
• Support cGMP manufacturing and technology transfer to GMP production facilities
• Develop strategies to ensure process performance through process understanding, modeling and characterization
• Guide successful completion of project deliverables and ensure timelines are met
• Work cross-functionally to deliver regulatory documents and support regulatory filings
• Serve as a technical expert and keep current in the field of bioconjugation manufacturing
• Coach and provide career and scientific / technical advice to colleagues within the organization

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.

Basic Qualifications

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of Scientific experience OR Master’s degree and 6 years of Scientific experience OR Bachelor’s degree and 8 years of Scientific experience

Preferred Qualifications

• Doctoral degree and 5+ years in the pharmaceutical industry with expertise in bioconjugate process development, preferably in Antibody Drug Conjugates (ADCs) with HPAPI linker-payload synthesis experience GMP manufacturing and technology transfer to CMOs
• Demonstrated functional representation on a CMC or PDT team
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
• People-centered leadership skills in building strong teams through mutual trust and respect and exhibits Amgen leadership attributes of inspire, accelerate, integrate, and adapt
• Proven track record of publications, patents and presentations

What you can expect of us

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Salary Range 157,737.05USD -213,408.95 USD

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www.amgen.com and follow us on www.twitter.com/amgen

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship for this role is not guaranteed.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.