Process Development Engineer I, Late-Stage Purification

Regeneron Pharmaceuticals, Inc.; Village of Tarrytown (NY); On-site; USD 85,000 - 110,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. seeks a Process Development Engineer I to join the Late-Stage Purification Development team in Preclinical Manufacturing and Process Development (PMPD).

The role involves developing and transferring harvest, affinity chromatography, and viral inactivation processes for recombinant proteins using Quality by Design principles, on-site in Tarrytown, NY. Responsibilities include designing and executing bench-to-pilot experiments, analyzing data, documenting results,

Qualifications

• Bachelor’s or Master’s degree in Chemical Engineering, Biochemical Engineering, Biochemistry, or a related field.
• Hands-on experience with purification techniques and unit operations.
• Experience with process automation, hardware control, and HMI development.

Responsibilities

• Design and execute experiments at bench and pilot scale.
• Analyze data, draw conclusions, and propose next steps.
• Document results in notebooks and reports for leadership.
• Serve as purification development SME during manufacturing process transfer for GMP batches.
• Collaborate cross-functionally to enable a robust manufacturing process.
• Support technology development by automating pilot-scale operations and evaluating new materials/equipment.

Skills

Experimental design

Data analysis

Process transfer

Automation

Education

Bachelor's or Master's in Chemical/Biochemical Engineering or Biochemistry

Tools

AKTA systems

HPLC

UPLC

Empower

Unicorn

JMP

LIMS

Python

Ignition

PI Historian

Job description

Build Our Future Together

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Process Development Engineer I to join our Late-Stage Purification Development team within Preclinical Manufacturing and Process Development (PMPD) in an on-site capacity. In this role, you will develop and transfer harvest, affinity chromatography, and viral inactivation processes for recombinant proteins using Quality by Design principles, while collaborating with process development and manufacturing colleagues.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & Where

• Location: Tarrytown, NY
• Work model: On-site

Discover Your Role

• Design and execute experiments at bench and pilot scale
• Analyze data, draw conclusions, and propose next steps
• Document results in laboratory notebooks and reports, and share findings with functional area and department leadership
• Serve as purification development subject matter expert during manufacturing process transfer to support successful GMP batches
• Collaborate cross-functionally with the process development team to enable a robust, cohesive manufacturing process
• Support technology development, such as automating pilot-scale unit operations, improving bench-scale process models, building historical data workflows, and evaluating new raw materials, equipment, or techniques
• Train and mentor peers, co-op students, and interns in running experiments, analyzing data, and documenting results
• Contribute to lab equipment maintenance and lab safety to keep our working environment safe, effective, and efficient

This Role Requires

• Bachelor's or Master's degree in Chemical Engineering, Biochemical Engineering, Biochemistry, or a related field, with 0-2 years of recombinant protein purification experience
• Hands-on experience with techniques such as depth filtration, disc stack centrifugation, column chromatography, virus retentive filtration, ultrafiltration/diafiltration, and buffer preparation
• A solid understanding of, and practical experience in, purifying monoclonal antibodies or other biopharmaceuticals
• Experience with process automation, such as hardware, control logic, and/or HMI development
• Thr… ???
• Preferred: strong fundamental understanding of protein purification techniques
• Preferred: experience with Akta chromatography systems, HPLC, UPLC, Empower, Unicorn, JMP, LIMS, Python, Ignition, and PI Historian

#pmpd

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing