Principal Software Engineer

Baylor Genetics; United States; Remote; USD 170,000 - 210,000; Full time

Job summary

Baylor Genetics in the United States is seeking a Senior Software Architect to lead the architecture, design, and development of complex software platforms in a remote-enabled IT environment. You will define engineering standards, drive long-term technical roadmaps, and mentor engineers across teams.

Collaborate with product, bioinformatics, and operations to deliver scalable, secure solutions while ensuring regulatory compliance.

Qualifications

• BS in Computer Science or related field required.
• 10+ years of professional software engineering experience.
• Expert-level proficiency with C# and .NET.
• Extensive experience architecting and building React + TypeScript applications.
• Deep expertise with relational databases (SQL Server, PostgreSQL, MySQL) and RESTful APIs.
• Strong background in software architecture, system design, and engineering best practices.
• Experience leading technical initiatives and mentoring engineers; solid DevOps/CI‑CD knowledge.

Responsibilities

• Lead the architecture, design, and development of complex software systems and platforms.
• Define and champion engineering standards, best practices, and long-term technical roadmaps.
• Collaborate with cross-functional teams to translate business needs into scalable, secure solutions.
• Conduct deep technical reviews and guide system design discussions across teams.
• Mentor engineers and foster a culture of technical excellence and continuous learning.
• Drive root-cause analysis and reliability improvements; ensure data integrity and security compliance.
• Evaluate emerging technologies and guide strategic adoption; partner with product, laboratory, and bioinformatics teams to optimize workflows.

Skills

C#

.NET

React

TypeScript

Agile

SDLC

HTML

Angular

Education

B.S. in Computer Science or related field

M.S. in Computer Science or related field

Tools

SQL Server

PostgreSQL

MySQL

RESTful APIs

DevOps

CI/CD

Cloud-native architectures

Job description

Job Category: Information Technology (IT)

Requisition Number: PRINC002571

• Posted : October 23, 2026
• Full-Time
• Remote

Locations

Showing 1 location

Remote
United States

Description

KEY RESPONSIBILITES

• · Lead the architecture, design, and development of complex software systems and platforms
• · Define and champion engineering standards, best practices, and long-term technical roadmaps
• · Collaborate with cross-functional teams to translate business needs into scalable, secure, and maintainable solutions
• · Conduct deep technical reviews, guide system design discussions, and ensure architectural consistency across teams
• · Mentor and coach engineers, fostering a culture of technical excellence and continuous learning
• · Drive root-cause analysis and resolution of complex technical issues, ensuring system reliability and data integrity
• · Evaluate emerging technologies and guide strategic adoption where appropriate
• · Partner with product, laboratory, and bioinformatics teams to optimize workflows and enhance operational efficiency
• · Ensure compliance with security, privacy, and regulatory requirements across all software systems
• · Contribute to innovation initiatives that advance Baylor Genetics’ digital capabilities and competitive advantage
• · Perform other duties as assigned to support team and organizational objectives.
• · Comply with all company policies, procedures, and applicable regulatory requirements.

QUALIFICATIONS

Required

• · B.S. in Computer Science or related field required
• · 10+ years of professional software engineering experience, including significant experience in large-scale or complex systems
• · Expert-level proficiency with C# and .NET (e.g., .NET Core / .NET 6+)
• · Extensive experience architecting and building React + TypeScript applications
• · Deep expertise with relational databases such as MS SQL Server, PostgreSQL, or MySQL, including schema design, performance tuning, and data modeling
• · Proven experience designing, implementing, and governing RESTful APIs and distributed systems
• · Strong background in software architecture, system design, and engineering best practices
• · Demonstrated experience leading technical initiatives, mentoring engineers, and influencing cross-functional decision-making
• · Strong understanding of DevOps principles, CI/CD pipelines, and cloud-native architectures
• · Excellent analytical and problem-solving skills with the ability to navigate ambiguity and complexity
• · Equivalent combination of education and experience may be considered.

Preferred

• · M.S. or higher preferred in Computer Science or related field
• · Experience in healthcare, clinical diagnostics, genomics, or NGS environments
• · Familiarity with laboratory workflows, LIMS systems, or clinical reportingplatforms
• · Experience working in regulated environments (CLIA, CAP, HIPAA)
• · Background in designing secure, compliant, and audit-ready systems
• · Experience with high-performance or data-intensive applications, including optimization and scalability strategies

COMPETENCIES

• · A strategic technical leader who can define long-term architectural direction
• · Strong ownership mindset with the ability to drive initiatives from concept to production
• · Exceptional communication skills, capable of translating complex technical concepts for diverse audiences
• · A collaborative partner who elevates team performance and mentors engineers at all levels
• · Sound judgment balancing innovation, speed, quality, and regulatory requirements
• · Passion for building systems that directly support clinical decision-making and patient outcomes

PHYSICAL DEMANDS AND WORK ENVIRONMENT

EEO Statement:

Baylor Genetics is proud to be an equal opportunity employer committed to fostering an inclusive and diverse workplace. We welcome and encourage applicants from all backgrounds to apply. We do not discriminate on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, age, veteran status, disability, genetic information, pregnancy, childbirth, or any other status protected by applicable federal, state, or local law. If you need an accommodation during the application process, please contact our Human Resources team.

Qualifications

Skills

Required

CI/CD practices [Job Descriptions | Word]

Expert

C#

Expert

.NET

Expert

Expert

SQL Server

Expert

Agile

Expert

RESTful API’s

Expert

SDLC

Expert

React

Expert

HTML

Expert

Angular

Expert

Preferred

Expert

Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws.For further information, please review the Know Your Rights notice from the Department of Labor.