Principal Scientist, Target Discovery & Portfolio Strategy

xairatherapeutics; South San Francisco (CA); Hybrid; USD 164,000 - 205,000; Full time

Benefits offered by this job

Competitive compensation and benefits

Equity

Job summary

Xaira Therapeutics is seeking a Principal Scientist in immunology to identify new therapeutic opportunities and shape the company’s portfolio. You will integrate internal datasets, human genetics, and published research to prioritize opportunities that address patient needs and build on Xaira's target discovery and antibody design platforms.

This role involves leading discovery programs, applying multi-omics data, and coordinating with design, engineering, and screening teams to translate

Qualifications

• PhD in immunology or a related field with 6+ years of industry experience in drug discovery, target discovery, preclinical drug development, or translational drug development.
• Experience drawing on human genetics, genome-scale multi-omics datasets, and other human data alongside cell biology, disease biology, and clinical findings to evaluate therapeutic hypotheses.
• Strong scientific judgment and the ability to distinguish an interesting association from a credible therapeutic opportunity.
• Clear communication skills and the ability to guide decisions across disciplines.
• Curiosity, independence, and a willingness to challenge assumptions and revise recommendations as the evidence evolves.

Responsibilities

• Identify promising disease areas. Assess unmet needs, disease mechanisms, patient subsets, and the limitations of current treatments.
• Find and prioritize targets. Combine human genetics, functional genomics, genome-scale multi-omics datasets, and patient data to develop strong therapeutic hypotheses.
• Assess platform fit. Work with molecular design, protein engineering, and functional screening teams to identify opportunities where our platforms could offer a therapeutic advantage.
• Evaluate the evidence. Assess causality, the desired direction of target modulation, safety risks, and key knowledge gaps.
• Build clear recommendations. Develop concise target assessments covering disease rationale, patient selection, competition, differentiation, and risks.
• Track emerging science and competition. Follow publications and clinical results, and monitor the competitive landscape to identify new opportunities and inform priorities.
• Use AI tools to analyze multi-modal data.
• Lead discovery programs or platform initiatives.

Skills

Scientific judgment

Communication skills

Curiosity

Independence

Challenge assumptions

Education

PhD in immunology

Job description

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

We are looking for a Principal Scientist with a strong background in immunology to identify new therapeutic opportunities and help shape Xaira's portfolio.

You will integrate internal datasets, human genetics, and published research to prioritize opportunities that address patient needs and build on Xaira's target discovery and antibody design platforms. This role is ideal for someone who enjoys connecting scientific findings and translating them into strategic decisions.

In this role, you will:

• Identify promising disease areas. Assess unmet needs, disease mechanisms, patient subsets, and the limitations of current treatments.
• Find and prioritize targets. Combine human genetics, functional genomics, genome-scale multi-omics datasets, and patient data to develop strong therapeutic hypotheses.
• Assess platform fit. Work with molecular design, protein engineering, and functional screening teams to identify opportunities where our platforms could offer a therapeutic advantage.
• Evaluate the evidence. Assess causality, the desired direction of target modulation, safety risks, and key knowledge gaps.
• Build clear recommendations. Develop concise target assessments covering disease rationale, patient selection, competition, differentiation, and risks.
• Track emerging science and competition. Follow publications and clinical results, and monitor the competitive landscape to identify new opportunities and inform priorities.
• Use AI tools to analyze multi-modal data.
• Lead discovery programs or platform initiatives.

We are looking for someone with:

• PhD in immunology or a related field with 6+ years of industry experience in drug discovery, target discovery, preclinical drug development, or translational drug development.
• Experience drawing on human genetics, genome-scale multi-omics datasets, and other human data alongside cell biology, disease biology, and clinical findings to evaluate therapeutic hypotheses.
• Strong scientific judgment and the ability to distinguish an interesting association from a credible therapeutic opportunity.
• Clear communication skills and the ability to guide decisions across disciplines.
• Curiosity, independence, and a willingness to challenge assumptions and revise recommendations as the evidence evolves.

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $164,000-$205,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Equal Opportunity Employer

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.