Principal Scientist, Oncology Drug Discovery

1925 GlaxoSmithKline LLC; Cambridge (MA); On-site; USD 116,000 - 193,000; Full time

Benefits offered by this job

Health insurance

Retirement benefits

Paid holidays

Vacation

Job summary

GlaxoSmithKline plc is seeking a Principal Scientist in Oncology Drug Discovery for the ITCT Biology Unit, supporting precision oncology assets. The role requires designing and executing cellular/molecular biology studies to understand mechanisms of action of small molecule cancer therapeutics.

On-site in Cambridge, MA or Upper Providence, PA with no remote option. You will lead in vitro experiments, contribute to portfolio asset development, and collaborate with a global matrix team.

Qualifications

• BS/MS/PhD in Cell, Molecular, or Cancer Biology or related life sciences.
• 3 years of designing, executing, and analyzing cellular/molecular biology experiments with small-molecule therapeutics.

Responsibilities

• Design, execute, and oversee in vitro experiments for portfolio assets.
• Support target validation, drug discovery, and early clinical development of small-molecule cancer therapies.
• Develop and apply mechanistic biology and assay development; build cross-functional communication.

Skills

Cell biology

Molecular biology

Cancer biology

Experimental design

Education

BS/MS/PhD in Cell, Molecular, or Cancer Biology

Tools

Genomic editing

Job description

About Us

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programs, pension plan membership, and shares and savings programme. We embrace modern work practices; our Performance with Choice programme offers a remote or hybrid working model, empowering you to find the optimal balance between remote and in-office work. Discover more about our company-wide benefits and life at GSK on our webpage Life at GSK | GSK Find out more about GSK and R&D:

Principal Scientist, Oncology Drug Discovery

The Intracellular Targeted Cancer Therapeutics (ITCT) Biology Unit within the Oncology Research Unit is seeking an experienced Cancer Biologist for an Investigator role that will support a growing portfolio of precision oncology assets. The successful candidate will have a background in cancer biology with experience designing and executing biological studies to understand the mechanism of action small molecule cancer therapeutics. We value curious, motivated scientists who take ownership, communicate clearly, and thrive in a collaborative environment. This role offers you a chance to grow your skills, make a meaningful impact, and contribute to GSK’s mission of uniting science, technology, and talent to get ahead of disease together. This role can be in the United States in either Cambridge, MA or Upper Providence, PA and requires working on-site. Hybrid or remote work options are not available for this position. This role will provide YOU the opportunity to lead key activities to progress YOUR career.

Responsibilities

• Work within a dynamic and global matrix team environment providing basic and translational biology support for target validation, drug discovery, and early clinical development of novel small molecule cancer therapies.
• Work independently to design, execute, and/or oversee impactful in vitro experiments to inform the development of portfolio assets.
• Champion innovative experimental techniques or technologies, including medium-throughput scalable assay development, target-specific mechanistic biology, and monotherapy and combination anti-cancer efficacy testing of assets.
• Build communication networks across the Oncology Research Unit and broader organization.
• Guide the maturation and de-risking of novel therapeutic concepts.

Basic Qualifications

• BS, MS, or PhD in Cell, Molecular, or Cancer Biology, Pharmacology, or a related life sciences field (BS and a minimum of 5 years of relevant industry experience, MS and a minimum of 3 years of relevant industry experience, or PhD and 0 years of relevant industry experience).
• A minimum of 3 years of experience in designing, executing, and analyzing cellular and molecular biology experiments using small molecular therapeutics and a diverse array of current scientific techniques.

Preferred Qualifications

• A minimum of 2 years of drug discovery experience in a biotech, preclinical CRO or pharmaceutical company.
• Deep knowledge in the field of molecular oncogenesis, signaling pathway, bivalent or molecular glue modality.
• Deep expertise in assay development in a drug discovery setting.
• Experience in applying genomic editing techniques to dissect target biology and drug mechanisms.
• Proven track record of scientific expertise and achievement in cell biology and cancer biology through peer-reviewed publications.
• Working knowledge of omic methods (e.g., sequencing, transcriptomics, and/or proteomics) and databases (e.g., TCGA, CCLE, DepMap, etc.).
• Attention to detail and proficient reasoning skills in experimental design, data analysis, statistical methods, and interpretation.
• Independence, problem-solving abilities, self-motivation, resourcefulness, and organizational, interpersonal, and communication skills and the ability to work efficiently in a fast-paced team environment.

Salary and Benefits

If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $115,500 to $192,500. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role.

• health care and other insurance benefits (for employee and family)
• retirement benefits
• paid holidays
• vacation
• paid caregiver/parental and medical leave
• annual bonus and eligibility to participate in our share based long-term incentive program
• competitive salary
• annual bonus based on company performance
• healthcare and wellbeing programs
• pension plan membership
• shares and savings programme

Why GSK

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

Equal Opportunity Employer

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Accommodation Contact

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - [e-mail]

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

Find out more on our career site.