Principal Scientist - Modeling & Simulation

BioSpace; Thousand Oaks (CA); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

Retirement plan

Stock-based incentives

Discretionary bonus

Flexible work model

Job summary

Amgen is seeking a Principal Scientist in Modeling & Simulation to support clinical pharmacology programs. You will build PK/PD and exposure–response models, conduct advanced analyses, and contribute to dose selection across therapeutic areas.

The role requires a PhD/MD/PharmD with extensive modeling experience and proficiency in NONMEM, SAS, R, STAN, and MATLAB, with collaboration across cross-functional teams.

Qualifications

• PhD/MD/PharmD with relevant modeling experience or higher degree with PK/PD exposure.
• Strong background in pharmacometrics and exposure–response analyses.
• Experience with population PK/PD and Bayesian methods.

Responsibilities

• Build pharmacostatistical models for PK/PD and exposure–response analyses.
• Conduct binary and time-to-event data analyses and Bayesian approaches.
• Perform meta-analysis using proprietary or literature data.
• Collaborate in cross-functional teams to inform dose selection and study design.
• Contribute to clinical pharmacology strategy and project plans.
• Generate modeling reports and support regulatory submissions.

Skills

Pharmacometric analyses

Statistical modeling

Population PK/PD

Binary/Categorical data analysis

Bayesian methods

Education

PhD in Pharmaceutical Sciences or related

MD or PharmD with postdoc or PK/PD modeling exp

Masters with PK/PD modeling exp

Bachelors with 7 years PK/PD modeling exp

Tools

NONMEM

SAS

R

STAN

MATLAB

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Scientist - Modeling & Simulation

What You Will Do

Lets do this. Lets change the world. In this vital role you will support Amgen clinical development and translational sciences programs across multiple therapeutic areas as part of the Clinical Pharmacology, Modeling and Simulation department.

Key Responsibilities

• Building pharmacostatistical models to support Population Pharmacokinetics/Pharmacodynamic (PKPD) and exposure-response analyses using relevant state of the art modeling and simulation techniques.
• Conducting binary and categorical and binary data analyses, time-to-event (hazard) models, Poisson models, MCMC and Bayesian methods as applied to exposure-response analyses and Population PK and PKPD analysis.
• Performing meta-analysis using proprietary and/or literature data.
• Participating in cross-functional project teams and providing scientific input for dose selection, early and late study designs using modeling and simulation inputs.
• Contributing to clinical pharmacology strategy for the program(s) and implementing project plans.
• Generating modeling reports and contributing to the summary documents for regulatory submissions.

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The Principal Scientist we seek is a passionate professional with these qualifications.

Basic Qualifications

Doctorate degree PhD

OR

PharmD

OR MD [and relevant post-doc where applicable] and 2 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience

OR

Masters degree and 5 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience

OR

Bachelors degree and 7 years of Pharmacokinetics/Pharmacodynamic or statistical modeling experience

Preferred Qualifications

• PhD in pharmaceutical sciences, applied statistics/mathematics, bio-statistics, and/or engineering or related fields with equivalent professional degrees (e. g. MD, PharmD) with 3 years of PK/PD or statistical modeling experience
• 5 + years industry or relevant academic experience in pharmacometric analyses and/or applied bio-statistics of small molecules and/or biologics.
• Proficiency in modeling software (e. g. NONMEM, SAS, R/S-Plus, STAN, MATLAB)

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.