Principal Scientist (LBA)

The Steely Group; Kansas; On-site; USD 140,000 - 230,000; Full time

Job summary

The Steely Group is seeking a Principal Scientist, BioPharma Sciences to provide scientific leadership in bioanalytical assay development, validation, and troubleshooting for preclinical and clinical programs. Expertise in ligand binding assays (LBA) and cell-based methods with ELISA/MSD platforms is required, ensuring data integrity and GLP compliance.

You will mentor scientists, lead complex studies, and provide technical consultations to clients, translating study results into actionable

Qualifications

• Bachelor’s, Master’s, or PhD in Biology, Biochemistry, Immunology, or a related scientific field.
• Extensive hands-on bioanalytical laboratory experience in a GLP regulated environment.
• Strong expertise in LBA platforms, including ELISA, MSD, or similar immunoassays.
• Hands-on experience with NAb, cell-based, biomarker, PK, and ADA assays.
• Proven experience in assay development, validation, and troubleshooting.
• Experience providing scientific leadership, client consultation, and mentorship.

Responsibilities

• Lead development, optimization, qualification, validation, and troubleshooting of ligand binding and cell-based assays.
• Provide technical expertise across NAb, ADA, PK, biomarker, and cell-based assays using platforms such as ELISA and MSD.
• Interpret complex data and resolve assay performance challenges.
• Oversee study execution, data integrity, protocols, and scientific documentation.
• Mentor Scientists and Senior Scientists and provide technical guidance.
• Partner with Quality Assurance to support audits, inspections, and GLP compliance.
• Provide technical consultation and recommendations for complex bioanalytical programs.
• Communicate study strategies, results, and scientific findings to clients and internal stakeholders.

Skills

LBA platforms expertise

Bioanalytical leadership

ELISA/MSD experience

Client consultation

Mentorship

Education

Bachelor’s/Master’s/PhD in Biology or related field

Tools

ELISA

MSD

Immunoassays

Job description

The Principal Scientist, BioPharma Sciences provides scientific leadership for bioanalytical assay development, validation, and troubleshooting in support of preclinical and clinical drug development programs. This role specializes in ligand binding assays (LBA) and cell based methods, ensuring scientific rigor, data integrity, and compliance with GLP requirements.

The Principal Scientist will lead complex studies, provide technical consultation to clients, mentor scientists, and support continuous improvement of bioanalytical capabilities.

Key Responsibilities:

Bioanalytical Assay Development

• Lead development, optimization, qualification, validation, and troubleshooting of ligand binding and cell based assays.
• Provide technical expertise across NAb, ADA, PK, biomarker, and cell based assays using platforms such as ELISA and MSD.
• Interpret complex data and resolve assay performance challenges.

Scientific Leadership & Quality

• Oversee study execution, data integrity, protocols, and scientific documentation.
• Mentor Scientists and Senior Scientists and provide technical guidance.
• Partner with Quality Assurance to support audits, inspections, and GLP compliance.

Client Consultation

• Provide technical consultation and recommendations for complex bioanalytical programs.
• Communicate study strategies, results, and scientific findings to clients and internal stakeholders.

Qualifications & Experience:

• Bachelor’s, Master’s, or PhD in Biology, Biochemistry, Immunology, or a related scientific field.
• Extensive hands on bioanalytical laboratory experience in a GLP regulated environment.
• Strong expertise in LBA platforms, including ELISA, MSD, or similar immunoassays.
• Hands on experience with NAb, cell based, biomarker, PK, and ADA assays.
• Proven experience in assay development, validation, and troubleshooting.
• Experience providing scientific leadership, client consultation, and mentorship.

Core Competencies:

• Strong analytical and problem solving skills.
• Excellent communication and client facing abilities.
• Commitment to scientific integrity, quality, and regulatory compliance.

Additional Information:

Management reserves the right to modify duties and responsibilities as business needs evolve.